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How to read DNA?
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Vladimir Kiselev
March 04, 2015
Education
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180
How to read DNA?
Presentation for pupils at the Babraham Institute School Day
Vladimir Kiselev
March 04, 2015
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Transcript
H O W T O R E A D D
N A ?
H E L A C E L L S (
W H Y H E L A ? )
H E L A C E L L S It
is the oldest and most commonly used human cell line. It was derived from cervical cancer cells taken on February 8, 1951, from Henrietta Lacks, a patient who eventually died of her cancer on October 4, 1951.
Let us assume you managed to extract the DNA from
HELA cells D N A
D N A S
D N A I S V E RY L O
N G
D N A S O U P
T H E N E W S PA P E
R P R O B L E M
T H E N E W S PA P E
R P R O B L E M
B A C K T O B I O L
O G Y ? Bioinformatics Bioinformatics Biology Biology Biology
O V E R L A P P I N
G I S E A S Y (if the sequence is known)
O V E R L A P P I N
G I S H A R D (if the sequence is unknown) Find a path in the de Bruijn graph that visits every edge exactly once - Eulerian path
W H AT I S T H E FA S
T E S T M A M M A L ?
S O , W H AT D I D J
U N E 2 7 , 2 0 0 0 N Y T I M E S S AY ?
S O , W H AT D I D J
U N E 2 7 , 2 0 0 0 N Y T I M E S S AY ?
T H A N K Y O U ! Presentation
is based on materials from https://www.coursera.org/course/bioinformatics