Slide 24
Slide 24 text
Use informative genomic regions that are clearly methylated or
unmethylated for each cell type
1. Initialize parameter values
2. Use EM algorithm for estimation
Estimation
θi
(0) = (πi1
(0),πi2
(0),...,πiK
(0),α0
(0),α1
(0),(σ0
2 )(0),(σ1
2 )(0),(σ 2 )(0) )