Slide 14
Slide 14 text
Gene
Ontology
• Ontology
=
formal
representa2on
of
a
knowledge
domain.
• Gene
ontology
=
cell
biology.
• GO
represented
by
directed
acyclic
graph
(DAG).
– Terms
are
nodes,
rela2onships
are
edges.
– Parent
terms
are
more
general
than
their
child
terms.
– Unlike
a
simple
tree,
terms
can
have
mul2ple
parents.
September
10,
2013
bioinforma2cs.virginia.edu
Rhee,
S.
Y.,
Wood,
V.,
Dolinski,
K.,
&
Draghici,
S.
(2008).
Use
and
misuse
of
the
gene
ontology
annota2ons.
Nature
reviews.
Gene2cs,
9(7),
509-‐15.
doi:10.1038/nrg2363