A Tech-BIO for a new AI drug discovery Akihiro Imura, MD, Ph.D CEO/Founder

Google Map https://www.nature.com/scitable/topicpage/cell-differentiation- and-tissue-14046412/ COGNANO Map https://datasets.cognanous.com

The new AI drug discovery Unknown Target (antigen) Drug (antibody)

VLPPYTRKKGDMLKGK ｜｜｜｜｜｜｜｜ TYDDQRESLLPKEWPR Large Language Model (LLM) The Principle 2023 Drug (antibody) Unknown Target https://arxiv.org/abs/2405.18749

Antibody type Conv. antibody VHH Digital information Not suitable Big Data via NGS VHH VHH: variable domain of heavy chain of heavy chain antibody

MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQPGGSLTLSCEASDRPLTYFAISWFRQAAGKEREVVSCIGSGATSSNYADSVKGRFTISRDDAKNTVYLQMDSLKPEDTAVYYCAAGSLHCSFNVWRGGDAYDYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQPGGSLRLSCAASGFTFSSNTMSWVRQAPGKGLEWISGIKPGGDTKYADPVRGRFTISRDNAKNTLYLQMDSLKPEDTAVYYCAIGYYGTSARGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLAQPGGSLRLSCAASGFTADKLTWFRQTPGREREGVSCIRTDDASTFYADSVKGRFTISTDDTKTVVYLQMNSLRPEDTGVYYCATDFGSTRQRRCSLKDIGAYTYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQAGGSLRVSCAATGLTFTAYKMGWFRQTPGKAREFVAFIARNGITTHYAEAVKGRFTISRDNAKNTLYLQMNSLRPEDTAMYYCSLTTTGGDYYIPTVDDQYDYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQAGGSLRLSCAASGPTFSSYHIAWFRQAPWKEREFVAAINWSGGSTYYADSVKGRFTISRDNTKNTVYLQMNSLKPEDTAVYYCAVYDEGAAKYDYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQPGGSLSLSCVVSGESFDYYAIGWFRQAPGKEREGVSCISSLGGTTNYADSVKGRFTISRDNAKNTVYLRMNSLKPEDTGVYYCAAVVGGKYFPLCSGGMDYWGKGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGAVQPGGSLRLSCAASGFTLEHYAVAWFRQAPGKEREGVSCISRNDRTSWSADSVRGRFTISRDNAKATVFLQMNNLKPEDTAVYYCATGYSITCSRDYKTYDYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQAGGSLRLSCAASGRTFSAYAMGWFRQAPGKEREFVAGISWTGGSTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAAEELGLGYGSSRYNYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQPGGSLRLSCAASGSTLTYYAIGWFRQAPGKEREGVSCISSSGAYTNYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCAADIQGKRFPTVQAMCAEYRNYGGMDYWGKGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQPGGHLRLSCVGSGFTLDHYGIGWFRQAPGKGREAISCIGSTGTPNYAENVKGRFTISRDTAKNTVYLQMNRLTPEDTAVYYCAADDWGCIGVIHDSGAEYKYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQVGDSLRLSCTVSGGVFSNYAMGWFRQAPRKAREFVAGITGDGGSREYADSVEGRFSISRDNAKNTVYLQMNDLKPEDTAVYRCAAERKDTLYRRPSLYDKWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQPGGSLRLSCAASGRTISSRAVGWFRQAPGKEREFVAAINWKGLTTDYADSVQGRFTISRDNAKNTVALEINRLTPEDTAVYYCAAGDSGAPYLSRHPHQWGYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQPGGSLRLSCAGTGFTLEYYAIGWFRQDPGKEREGVSCISTRDGIHYSDSVKGRFTISKDDAKNTVYLQMDSLKPEDSARYHCATVLGPCGRVWYRRGSFGYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQAGGSLRLSCAASGRTFSTDDMAWFRQAPGKEREFVAAINWSGGTTFYRDSVKGRFTISRDNPKNTVYLRMNSLKPEDTAVYYCAGRTRLRIARWQAEDTYDYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQTGGSLRLSCAASGRTFSGEAMGWFRQAPGKEREFTAAISESGRLRSYADSVKGRFTISRDNAKNTVYLQMNGLKPEDTAVYYCAATTLGISREEHNYHYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQAGGSLRLSCAASGRTFSDSAMGWFRQAPGKEREWVASINWTGHETNYADSVKGRFTISRDNAKNTMYLQMNSLKPEDTAVYYCAAASKWGRTTSQNLYDYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQPGGSLRLACTASGFSVDVYSIGWFRQAPGKEYEGLSCISGNGRITNYADSVNGRFTVSRENAKNTVYLQMNSLKPEDTAVYYCAVDRLCTHYTGDYYYSRKGEYDYWGQGTQVTVSSHHHHHH MKYLLPTAAAGLLLLAAQPAMAQVQLQESGGGLVQAGGSLRLSCTASGFTFDDYGIGWFRQAPGKEREGVSSITISDGRPSYADSVKGRFRITSDNAKNTVYLQMNSLKPEDTAVYYCAARSVDYIDYPIDGEVPLPSQSEYEYWGQGTQVTVSSHHHHHH Amino acid residues composing an antibody The first Big Data-Base of labeled Antigen/Antibody VHH https://www.nature.com/scitable/topicpage/cell-differentiation-and- tissue-14046412/ COGNANO Map

Biomarker Findings

Algorithm Drug discovery pipelines Platform on going The largest DB

Super Rapid Therapeutics Released against ʻunmet medical needs with no biomarkerʼ Spring 2024 TNBC Summer 2024 Autumn 2024 Winter 2024 ADC pipelines launched with 2 Biotech companies License-out Collaboration Partnering with academia partnering In-house pipeline In-house pipeline Peer-reviewed reports: https://www.nature.com/articles/s42003-022-03630-3 https://academic.oup.com/jb/article/173/2/115/6840705?login=false https://www.nature.com/articles/s43856-022-00213-5 Patents pending: ・JP 2020-163847 ・PCT/JP 2022/021447 ・JP 2021-170471 ・JP 2022-017180 ・JP 2022-182045 Licensing Spring 2025 Untreated cancers of no biomarker Pancreas & Cholangio Carcinoma - 90K(US) Glioblastoma - 9K(US) Thyroid Anaplastic Carcinoma - 1K(US) Small Cell Lung Cancer - 33K(US) TNBC: Triple Negative Breast Cancer - 300K(Global) world a place where all people live in well-being r of molecular information and technology. get) breast cancer cription cription cription. cription cription cription. cription Description Description Description Description ntreated cancers of biomarker reas & angio noma - US) Glioblastoma - 9K(US) oid Anaplastic Small Cell Lung TNBC: Triple Negative Breast Cancer - 300K(Global) ll people live in well-being ation and technology. treated cancers of biomarker as & ngio oma - ) Glioblastoma - 9K(US) d Anaplastic oma - 1K(US) Small Cell Lung Cancer - 33K(US) TNBC: Triple Negative Breast Cancer - 300K(Global) ption Description Description Description ption Description. Description Description ption Description Description Description. ption Description Description Description ption Description. Description Description ption Description Description Description. Untreated cancers of no biomarker Pancreas & Cholangio Carcinoma - 90K(US) Glioblastoma - 9K(US) Thyroid Anaplastic Carcinoma - 1K(US) Small Cell Lung Cancer - 33K(US) TNBC: Triple Negative Breast Cancer - 300K(Global) Description Description Description Description Description Description. Description Description Description Description Description Description. Description Description Description Description Description Description. Description Description Description Description Description Description. d cancers of rker Glioblastoma - 9K(US) Small Cell Lung Cancer - 33K(US) BC: Triple gative Breast ncer - K(Global) in well-being chnology. ion Description Description ion. Description Description Panc Thyroid Glioblastoma Lung

Investments Partnerships DB construction (IT) anti-cancer drug (Bio) ASK COGNANO makes drug discovery rapid and easy.