Slide 6
Slide 6 text
Identify haplotype differences
A
B
• CYP2D6 is involved in metabolizing >50% of available drugs
• Genetic variation and copy number affects drug efficacy
CYP2D6*10: Intermediate ~ poor metabolizer
CYP2D6*2: Extensive metabolizer
Seo, Rhie, Kim, and Lee et al., De novo assembly and phasing of a Korean human genome, Nature (2016)
Chr. 22