疫学・統計セミナー：データ解析と研究目的との関連

by Shuntaro Sato

Slide 1

Slide 1 text

σʔλղੳͱݚڀ໨తͱͷؔ࿈ $IVOUBSP !4IVOUBSPPP 1 Ӹֶɾ౷ܭηϛφʔ

Slide 2

Slide 2 text

2 0WFSWJFX w σʔλαΠΤϯεͷλεΫͷ෼ྨ w هड़ʢ%FTDSJQUJPOʣ w ༧ଌʢ1SFEJDUJPOʣ w ҼՌਪ࿦ʢ$BVTBM*OGFSFODFʣ w ҙࢥܾఆ w Ξ΢τϓοτΛҙࣝͨ͠ݚڀσβΠϯ w ࠓޙͷྲྀΕ

Slide 3

Slide 3 text

σʔλαΠΤϯε͸ݚڀʹ ͲͷΑ͏ʹؔΘΔ͔ 3

Slide 4

Slide 4 text

σʔλαΠΤϯεͷֶ໰ͱͯ͠ͷ෼ྨ 4 σʔλαΠΤϯε ౷ܭֶ ਓ޻஌ೳ ػցֶश

Slide 5

Slide 5 text

ࢀߟͱ͢Δจݙ 5 .JHVFM")FSOÂO +PIO)TV #SJBO)FBMZ "4FDPOE$IBODFUP(FU$BVTBM *OGFSFODF3JHIU"$MBTTJpDBUJPOPG %BUB4DJFODF5BTLT $)"/$& %0*

Slide 6

Slide 6 text

σʔλαΠΤϯεͷλεΫͷ෼ྨ 6 σʔλ هड़ʢ%FTDSJQUJPOʣ ༧ଌʢ1SFEJDUJPOʣ ҼՌਪ࿦ ʢ$BVTBM*OGFSFODFʣ .JHVFM")FSOÂO +PIO)TV#SJBO)FBMZ "4FDPOE$IBODFUP(FU$BVTBM*OGFSFODF3JHIU"$MBTTJpDBUJPOPG%BUB 4DJFODF5BTLT $)"/$& %0*

Slide 7

Slide 7 text

هड़ %FTDSJQUJPO 7

Slide 8

Slide 8 text

هड़ʢ%FTDSJQUJPOʣ 8 ཁ໿ʢ4VNNBSZʣ σʔλͷಛ௃Λ͋Γͷ··਺஋ʢ౷ܭྔʣͰࣔ͢ ՄࢹԽʢ7JTVBMJ[BUJPOʣ σʔλΛਤࣔ͢Δ ڭࢣͳֶ͠शʢ6OTVQFSWJTFEMFBSOJOHBMHPSJUINTʣ ม਺ؒɼ͋Δ͍͸ɼ؍ଌ஋ؒʹαϒάϧʔϓΛݟ͚ͭΔ

Slide 9

Slide 9 text

Պֶతٙ໰ʢ%FTDSJQUJPOʣ 9 ͋Δूஂͷ಺ɼ౶೘පΛױ͍ͬͯΔਓͷׂ߹͸ʁ ཁ໿ ͋ΔूஂΛ೥ؒ௥੻ௐࠪͨ͠ɽ೥ؒͰͷ౶೘පൃ঱ΛΞ΢τΧ Ϝͱ͢Δɽ౶೘පͷൃ঱ͱؔ࿈ͷ͋Δௐࠪ։࢝࣌ͷม਺͸Կ͔ʁ %FNPHSBQIJD -BCPSBUPSZ %JFU (FOPNF 'JUOFTT %JBCFUFT "TTPDJBUJPO

Slide 10

Slide 10 text

ཁ໿ʢ4VNNBSZʣ 10 தԝ஋ʢ.FEJBOʣ ฏۉ஋ʢ.FBOʣ ࠷খ஋ʢ.JOʣ ࠷େ஋ʢ.BYʣ ఺ ʢ2ʣ ఺ ʢ2ʣ UJNF ✖ ✖ ൃ঱ׂ߹ ൃ঱཰ ༗ප཰ ౶೘ප͋Γ ౶೘පͳ͠ உੑ ঁੑ

Slide 11

Slide 11 text

ՄࢹԽʢ7JTVBMJ[BUJPOʣ 11 ୯७ͳάϥϑ͸ ଞͷͲΜͳ΋ͷΑΓ΋ɼ σʔλΞφϦετͷ৺ʹڹ͘৘ใΛ ΑΓଟ͘΋ͨΒ͢ɽ +PIO5VLFZ w )JEB , .VSBUB ) *DIJOPNJZB 5 *OPVF ) 4BUP 4 )BSB 5 &⒎FDUTPGQSPHSBNNFEJOUFSNJUUFOUUIPSBDJDQBSBWFSUFCSBMCPMVTPG MFWPCVQJWBDBJOFPOUIFTQSFBEPGTFOTPSZCMPDLBSBOEPNJ[FE DPOUSPMMFE EPVCMFCMJOETUVEZ

Slide 12

Slide 12 text

ڭࢣͳֶ͠शʢ6OTVQFSWJTFEMFBSOJOHʣ 12 w /PWFNCSF + +PIOTPO 5 #SZD , ,VUBMJL ; #PZLP "3 "VUPO " 4UFQIFOT . (FOFTNJSSPSHFPHSBQIZXJUIJO&VSPQF/BUVSF w 4PNFPGUIFpHVSFTJOUIJTQSFTFOUBUJPOBSFUBLFOGSPN"O*OUSPEVDUJPOUP4UBUJTUJDBM-FBSOJOH XJUIBQQMJDBUJPOTJO3 4QSJOHFS XJUIQFSNJTTJPO GSPNUIFBVUIPST(+BNFT %8JUUFO 5)BTUJFBOE35JCTIJSBOJ ओ੒෼෼ੳ BREAST BREAST CNS CNS RENAL BREAST NSCLC RENAL MELANOMA OVARIAN OVARIAN NSCLC OVARIAN COLON COLON OVARIAN PROSTATE NSCLC NSCLC NSCLC PROSTATE NSCLC MELANOMA RENAL RENAL RENAL OVARIAN UNKNOWN OVARIAN NSCLC CNS CNS CNS NSCLC RENAL RENAL RENAL RENAL NSCLC MELANOMA MELANOMA MELANOMA MELANOMA MELANOMA MELANOMA BREAST BREAST COLON COLON COLON COLON COLON BREAST MCF7A−repro BREAST MCF7D−repro LEUKEMIA LEUKEMIA LEUKEMIA LEUKEMIA K562B−repro K562A−repro LEUKEMIA LEUKEMIA 40 80 120 160 Complete Linkage LEUKEMIA LEUKEMIA LEUKEMIA LEUKEMIA LEUKEMIA LEUKEMIA K562B−repro K562A−repro RENAL NSCLC BREAST NSCLC BREAST MCF7A−repro BREAST MCF7D−repro COLON COLON COLON RENAL MELANOMA MELANOMA BREAST BREAST MELANOMA MELANOMA MELANOMA MELANOMA MELANOMA OVARIAN OVARIAN NSCLC OVARIAN UNKNOWN OVARIAN NSCLC MELANOMA CNS CNS CNS RENAL RENAL RENAL RENAL RENAL RENAL RENAL PROSTATE NSCLC NSCLC NSCLC NSCLC OVARIAN PROSTATE NSCLC COLON COLON OVARIAN COLON COLON CNS CNS BREAST BREAST 40 60 80 100 120 Average Linkage LEUKEMIA RENAL BREAST EUKEMIA EUKEMIA CNS LEUKEMIA IA NSCLC LEUKEMIA OVARIAN NSCLC CNS BREAST NSCLC OVARIAN COLON BREAST MELANOMA RENAL MELANOMA MELANOMA ELANOMA LANOMA LANOMA LANOMA BREAST OVARIAN COLON WN IAN NSCLC NSCLC PROSTATE MELANOMA COLON OVARIAN NSCLC RENAL COLON ROSTATE COLON VARIAN COLON COLON NSCLC NSCLC RENAL NSCLC RENAL RENAL RENAL RENAL RENAL CNS CNS CNS 60 80 100 Single Linkage ֊૚తΫϥελϦϯά

Slide 13

Slide 13 text

༧ଌ 1SFEJDUJPO 13

Slide 14

Slide 14 text

Պֶతٙ໰ʢ1SFEJDUJPOʣ 14 w ೖӃ࣌ͷന݂ٿ਺ͷ஋Ͱɼिؒޙͷࢮ๢֬཰Λ༧ଌ͢Δ w ೖӃ࣌ʹه࿥ɾଌఆ͢Δݸͷม਺Ͱɼ िؒޙͷࢮ๢֬཰Λ༧ଌ͢Δ w ͋Δಛ௃Λ࣋ͭঁੑ͕ɼ೥ޙʹ೴ଔதΛൃ঱͢Δ֬཰Λ༧ଌ͢Δ w ͋Δಛ௃Λ࣋ͭஉੑͷ೥ޙͷମॏΛ༧ଌ͢Δ ݸਓ͝ͱͷ༧ଌ݁Ռ ͍Ζ͍Ζͳಛ௃ ʢม਺ʣ *OQVUʢೖྗʣ 0VUQVU ʢग़ྗʣ *OQVUͱ0VUQVUΛ ݸਓ͝ͱʹඥ͚ͮΔ िؒޙͷࢮ๢֬཰͸ ೥ޙͷ೴ଔதൃ঱֬཰͸ ೥ޙͷମॏ͸LH

Slide 15

Slide 15 text

Ϟσϧͷॊೈ͞ͱղऍͷ͠΍͢͞ 15 ղऍͷ͠΍͢͞ ௿ ߴ ௿ ߴ Ϟσϧͷॊೈ͞ ϒϥοΫϘοΫε͞ ύϥϝτϦοΫϞσϧ ϊϯύϥϝτϦοΫϞσϧ ઢܗϞσϧ ҰൠԽઢܗϞσϧ ܾఆ໦ ϥϯμϜϑΥϨετ σΟʔϓϥʔχϯά εϓϥΠϯ αϙʔτϕΫλʔϚγʔϯ

Slide 16

Slide 16 text

ύϥϝτϦοΫͱϊϯύϥϝτϦοΫ 16 Years of Education Seniority Income Years of Education Seniority Income ύϥϝτϦοΫ๏ ϊϯύϥϝτϦοΫ๏ εϓϥΠϯۂઢ 4PNFPGUIFpHVSFTJOUIJTQSFTFOUBUJPOBSFUBLFOGSPN"O*OUSPEVDUJPOUP4UBUJTUJDBM-FBSOJOH XJUIBQQMJDBUJPOTJO3 4QSJOHFS XJUIQFSNJTTJPO GSPNUIFBVUIPST(+BNFT %8JUUFO 5)BTUJFBOE35JCTIJSBOJ

Slide 17

Slide 17 text

۩ମྫʢղऍ͠΍͍͢༧ଌʣ 17 1SFEJDUJPOPG*ODJEFOU%JBCFUFT.FMMJUVTJO.JEEMFBHFE"EVMUT 5IF'SBNJOHIBN0⒎TQSJOH4UVEZ த೥੒ਓʹ͓͚Δ౶೘පൃ঱ͷ༧ଌ 8JMTPO 18 .FJHT +# 4VMMJWBO - 'PY $4 /BUIBO %. %`"HPTUJOP 3# 1SFEJDUJPOPGJODJEFOUEJBCFUFTNFMMJUVTJONJEEMFBHFEBEVMUT UIF'SBNJOHIBN0⒎TQSJOH4UVEZ"SDIJWFTPGJOUFSOBMNFEJDJOF ೥ྸ ੑผ ౶೘පͷՈ଒ྺ #.* ߴ݂ѹ )%-$ தੑࢷ๱ ۭෲ݂࣌౶ ෲғ ౶ෛՙݕࠪ ೥ޙͷ ౶೘පൃ঱ͷ༧ଌ ϞσϧΛ࡞੒

Slide 18

Slide 18 text

۩ମྫʢղऍ͠΍͍͢༧ଌʣ 18 ଟมྔϩδεςΟοΫճؼ෼ੳͰ ZS5%.΁ͷม਺ͷد༩ͱ༧ଌ 30$ΧʔϒͰ༧ଌੑೳΛධՁ 8JMTPO 18 .FJHT +# 4VMMJWBO - 'PY $4 /BUIBO %. %`"HPTUJOP 3# 1SFEJDUJPOPGJODJEFOUEJBCFUFTNFMMJUVTJONJEEMFBHFEBEVMUT UIF'SBNJOHIBN0⒎TQSJOH4UVEZ"SDIJWFTPGJOUFSOBMNFEJDJOF

Slide 19

Slide 19 text

۩ମྫʢղऍ͠΍͍͢༧ଌʣ 19 Table3ͷϩδεςΟοΫճؼ෼ੳ݁Ռ w ༧ଌ֬཰Λܭࢉͮ͠Β͍ w ࢖͍ͮΒ͍ Z = 0.994FY + 1.65)JHI#1 + ⋯ είΞϦϯά w ܭࢉ͠΍͍͢ w ༧ଌੑೳ͸Լ͕Δ 8JMTPO 18 .FJHT +# 4VMMJWBO - 'PY $4 /BUIBO %. %`"HPTUJOP 3# 1SFEJDUJPOPGJODJEFOUEJBCFUFTNFMMJUVTJONJEEMFBHFEBEVMUT UIF'SBNJOHIBN0⒎TQSJOH4UVEZ"SDIJWFTPGJOUFSOBMNFEJDJOF

Slide 20

Slide 20 text

۩ମྫʢϒϥοΫϘοΫεͷ༧ଌʣ 20 %JBHOPTUJD"TTFTTNFOUPG%FFQ-FBSOJOH"MHPSJUINTGPS%FUFDUJPO PG-ZNQI/PEF.FUBTUBTFTJO8PNFO8JUI#SFBTU$BODFS ೕ͕Μঁੑʹ͓͚ΔϦϯύઅసҠݕग़ͷͨΊͷ σΟʔϓϥʔχϯάΞϧΰϦζϜͷ਍அධՁ ػցֶश %FFQ-FBSOJOH 3BOEPN'PSFTU 47. సҠ͋Γ సҠͳ͠ ڭࢣσʔλ ೖྗ ֶश Ͳͬͪʁ ੑೳ ධՁ UFTUEBUB #FKOPSEJ #& 7FUB . 7BO%JFTU 1+ 7BO(JOOFLFO # ,BSTTFNFJKFS / -JUKFOT ( (FFTTJOL 0 %JBHOPTUJDBTTFTTNFOUPGEFFQMFBSOJOH BMHPSJUINTGPSEFUFDUJPOPGMZNQIOPEFNFUBTUBTFTJOXPNFOXJUICSFBTUDBODFS+BNB

Slide 21

Slide 21 text

۩ମྫʢϒϥοΫϘοΫεͷ༧ଌʣ 21 w਍அʹ͔͚Δ࣌ؒΛ੍ݶ͠ͳ͍පཧҩͱಉ͡Α͏ͳ਍அੑೳ wσΟʔϓϥʔχϯάͷํ͕࣌ؒ͸͔͔Βͳ͍ wػցֶशͷதͰ΋ɼ ಛʹσΟʔϓϥʔχϯά͸ϒϥοΫϘοΫεͱͳΔ wੑೳ͸҆ఆ͢Δ͕ɼղऍΛ͍ͨ͠৔߹͸͙ͦΘͳ͍ *OQVU ݁Ռ ϒϥοΫϘοΫε Կ͕ͲͷΑ͏ʹ ؔ࿈͍ͯ͠Δͷ͔ Θ͔Βͳ͍ #FKOPSEJ #& 7FUB . 7BO%JFTU 1+ 7BO(JOOFLFO # ,BSTTFNFJKFS / -JUKFOT ( (FFTTJOL 0 %JBHOPTUJDBTTFTTNFOUPGEFFQMFBSOJOH BMHPSJUINTGPSEFUFDUJPOPGMZNQIOPEFNFUBTUBTFTJOXPNFOXJUICSFBTUDBODFS+BNB

Slide 22

Slide 22 text

ҼՌਪ࿦ $BVTBM*OGFSFODF 22

Slide 23

Slide 23 text

ҼՌਪ࿦ʢ$BVTBM*OGFSFODFʣ 23 w େ௎͕ΜͷεΫϦʔχϯά͕ࢮ๢཰Λݮগͤ͞Δ͔ʁ w ελνϯΛ౤༩͢Δ͜ͱ͸ɼ ͋Δಛ௃Λ࣋ͭঁੑͷ೴ଔதͷϦεΫΛݮΒ͔͢ʁ ελνϯ ೴ଔத ަབྷ Ҽࢠ ม਺ؒͷؔ܎Λ੔ཧ͢Δ ໼ҹ͸ɼઐ໳Ոͷ஌ࣝʹΑΓ ߏங͢Δม਺ؒͷؔ܎ ڵຯ͋Δूஂ മ࿐ ඇമ࿐ ҼՌޮՌ WT ʢελνϯ౤༩ʣ ʢελνϯඇ౤༩ʣ ݪҼ ݁Ռ

Slide 24

Slide 24 text

w ݂ѹ͕ߴ͚Ε͹ɼ೥ऩ্͕͕Δ w ମॏ͕ॏ͚Ε͹ɼ଍͕଎͍ w λόίΛٵ͑͹ɼ৺ے伷࠹ʹͳΔ֬཰͕ߴ͍ w େ௎͕ΜεΫϦʔχϯάΛड͚Ε͹ɼ େ௎͕ΜʹΑΔࢮ๢Λ཈੍Ͱ͖Δ 24 ݪҼ ݁Ռ w ݂ѹ w ମॏ w ٤Ԏ w େ௎͕ΜεΫϦʔχϯά w ೥ऩ w ଍ͷ଎͞ w ৺ے伷࠹ w େ௎͕ΜʹΑΔࢮ๢ ໰͍͔͚

Slide 25

Slide 25 text

ҼՌؔ܎ͱ૬ؔؔ܎ 25 ݪҼ ݁Ռ ҼՌؔ܎ ݪҼ ݁Ռ ૬ؔؔ܎ w ݪҼ͕ى͖͔ͨΒ ݁Ռ͕ੜͨ͡ w ݪҼΛม͑ͨΒ ݁Ռ͕มΘΔ w ؔ܎͸͋Δ w ݪҼͱ݁Ռͷؔ܎͔ ෼͔Βͳ͍

Slide 26

Slide 26 text

ҼՌؔ܎Λ૬ؔؔ܎ͱ൑அ͢ΔͨΊͷϙΠϯτ 26 ͭͷม਺ͷؔ܎͕૬ؔؔ܎Ͱ͋Δ৔߹ɼ ͭͷ಺ͷ͍ͣΕ͔ʹ͋ͯ͸·Δ ʮ·ͬͨ͘ͷۮવʯͰ͸ͳ͍͔ ʮୈࡾͷม਺ʯ͸ଘࡏ͍ͯ͠ͳ͍͔ ʮٯͷҼՌؔ܎ʯ͸ଘࡏ͍ͯ͠ͳ͍͔ தࣨ຀ࢠɼ௡઒༑հ ʮݪҼͱ݁Ռʯͷܦࡁֶσʔλ͔Βਅ࣮Λݟൈ͘ࢥߟ๏μΠϠϞϯυࣾ

Slide 27

Slide 27 text

ʮ·ͬͨ͘ͷۮવʯͰ͸ͳ͍͔ 27 χίϥεɾέΠδͷ೥ؒөըग़ԋຊ਺ͱϓʔϧͷṆࢮऀ਺ !" IUUQUZMFSWJHFODPNTQVSJPVTDPSSFMBUJPOT

Slide 28

Slide 28 text

ʮୈࡾͷม਺ʯ͸ଘࡏ͍ͯ͠ͳ͍͔ 28 ݂ѹ څྉ ೥ྸ ݪҼ ݁Ռ ݟ͔͚ͤͷ૬ؔ ೥ྸ্͕͕Ε͹ څྉ΋্͕Δ ೥ྸ্͕͕Ε͹ ݂ѹ΋্͕Δ ަབྷҼࢠʢ$POGPVOEJOH'BDUPSʣ ݪҼʢ݂ѹʣͱ݁Ռʢڅྉʣʹ ӨڹΛ༩͑Δม਺ ୈࡾͷม਺

Slide 29

Slide 29 text

ʮٯͷҼՌؔ܎ʯ͸ଘࡏ͍ͯ͠ͳ͍͔ 29 ܯ࡯׭ͷ ਺ ൜ࡑͷ ൃੜ݅਺ ݪҼ ݁Ռ ٯͷҼՌؔ܎ ൜ࡑͷൃੜ݅਺ʹӨڹΛ༩͑ΔཁҼͷௐࠪΛ͍ͯͯ͠ ܯ࡯׭ͷ਺͕ଟ͍஍Ҭ͸ɼ൜ࡑ݅਺͕ଟ͍͜ͱ͕Θ͔ͬͨ ܯ࡯׭ͷ ਺ ൜ࡑͷ ൃੜ݅਺ ݪҼ ݁Ռ தࣨ຀ࢠɼ௡઒༑հ ʮݪҼͱ݁Ռʯͷܦࡁֶσʔλ͔Βਅ࣮Λݟൈ͘ࢥߟ๏μΠϠϞϯυࣾ

Slide 30

Slide 30 text

νϣίϨʔτফඅྔͱϊʔϕϧ৆ड৆ऀ਺ͱͷؔ܎ 30 w Ұਓ౰ͨΓͷνϣίϨʔτͷ೥ؒফඅྔ͕ଟ͍ࠃ΄Ͳɼ ϊʔϕϧ৆Λड৆͍ͯ͠Δਓͷ਺͕ଟ͍ͱ͍͏͜ͱ͕Θ͔ͬͨ .FTTFSMJ ') 4BSNBEJ # "NJOVEEJO ' )BNJE . 4BBSJ / "CEVM)BNJE " *TNBJM " $IPDPMBUFBOE:PVS)FBMUI/&OHM+.FE ͜Ε͸ҼՌؔ܎ͱ૬ؔؔ܎ͷ ͲͪΒͩΖ͏͔ʁ w ࠃຽ͕Ұਓ౰ͨΓ೥ؒH ଟ͘νϣίϨʔτΛઁऔ͢Δͱɼ ͦͷࠃͷϊʔϕϧ৆ड৆ऀͷ਺͕ ਓ૿͑Δ

Slide 31

Slide 31 text

ޮՌͱؔ࿈ʢʣ 31 ݪҼ ݁Ռ ҼՌؔ܎ ݪҼ ݁Ռ ૬ؔؔ܎ w ࠶ͼݪҼ͕ىͬͨ͜ͳΒɼ ಉ݁͡Ռ͕ಘΒΕΔ w ҼՌؔ܎͕͋Δͱ͖ɼݪҼͱ݁Ռͷ ؔ܎ΛޮՌʢ&⒎FDUʣͱ͍͏ w ࠶ͼݪҼ͕ىͬͨ͜ͱͯ͠΋ɼ ಉ݁͡Ռ͕ಘΒΕΔͱ͸ߟ͑ʹ͍͘ w ҼՌؔ܎Λࣔͤͳ͍ͱ͖ɼݪҼͱ݁Ռͷ ؔ܎Λؔ࿈ʢ"TTPDJBUJPOʣͱ͍͏ &⒎FDUͱ"TTPDJBUJPO͸ݫ֨ʹ۠ผ͢Δ

Slide 32

Slide 32 text

ޮՌͱؔ࿈ʢʣ 32 $BVTBM &⒎FDU "TTPDJBUJPO WT WT ݚڀର৅ूஂ εΫϦʔχϯά͋Γ εΫϦʔχϯάͳ͠ w ୯७ͳܭࢉ͔ΒಘΒΕΔͷ͸ɼؔ࿈ʢ"TTPDJBUJPOʣ w ޮՌʢ$BVTBM&⒎FDUʣΛܭࢉ͢Δʹ͸ɼҼՌਪ࿦͕ඞཁ w ൓ࣄ࣮ͱ͍͏֓೦Λಋೖ͢Δඞཁ͕͋Δ w ࠓޙɼઆ໌͠·͢ )FSOÂO." 3PCJOT+. $BVTBM*OGFSFODF#PDB3BUPO$IBQNBO)BMM$3$ GPSUIDPNJOH

Slide 33

Slide 33 text

൓ࣄ࣮ʢ$PVOUFSGBDUVBMʣ 33 ࣄ࣮ɹɿղ೤ࡎΛҿΜͩΒ೤͕Լ͕ͬͨ ൓ࣄ࣮ɿղ೤ࡎΛҿ·ͳ͔ͬͨΒɼ ɹɹɹɹ೤͸Ͳ͏ͳ͍ͬͯͨͩΖ͏ʁ ࣄ࣮ɹɿʓʓʹձ͔ͬͨΒɼҩྍऀΛ໨ࢦ͍ͯ͠Δ ൓ࣄ࣮ɿʓʓʹձΘͳ͔ͬͨΒɼԿʹͳ͍ͬͯͨͩΖ͏ʁ ҼՌؔ܎ͱ͸ ݪҼ͕ىͬͨ͜ͱ͍͏ʮࣄ࣮ʯʹ͓͚Δ݁Ռͱɼ ݪҼ͕ى͜Βͳ͔ͬͨͱ͍͏ʮ൓ࣄ࣮ʯʹ͓͚Δ݁ՌΛ ൺֱͯ͠Θ͔Δ

Slide 34

Slide 34 text

۩ମྫʢ3BOEPNJ[FEDPOUSPMMFEUSJBMʣ 34 ίϧώνϯແޮ͋Δ͍͸ෆ଱ͷՈ଒ੑ஍தւ೤ʢ'.'ʣΛର৅ͱ͠ ͨτγϦζϚϒͷϓϥηϘରরϥϯμϜԽೋॏ໡ݕฒߦ܈ؒൺֱࢼݧ ίϧώνϯແޮ͋Δ͍͸ ෆ଱ͷ'.'ױऀ R τγϦζϚϒ ϓϥηϘ XFFL XFFL ओཁධՁ߲໨ɿ ൃ೤ൃ࡞ճ਺ ⃗ xTCZ ⃗ xPlacebo ൃ೤ൃ࡞ճ਺ ༀࡎͷҧ͍ ༀࡎͷҧ͍ʢϓϥηϘͱൺֱͯ͠5$;ʣ͸ ൃ೤ൃ࡞ճ਺ʹӨڹΛ༩͑Δ͔ʁ ,PHB 5 4BUP 4 .JZBNPUP + )BHJNPSJ / ,BXB[PF : "SJOBHB , ,BXBLBNJ " $PNQBSJTPOPGUIFF⒏DBDZBOETBGFUZPGUPDJMJ[VNBCGPS DPMDIJDJOFSFTJTUBOUPSDPMDIJDJOFJOUPMFSBOUGBNJMJBM.FEJUFSSBOFBOGFWFSTUVEZQSPUPDPMGPSBOJOWFTUJHBUPSJOJUJBUFE NVMUJDFOUFS SBOEPNJ[FE EPVCMFCMJOE QMBDFCPDPOUSPMMFEUSJBM5SJBMT

Slide 35

Slide 35 text

۩ମྫʢ0CTFSWBUJPOBMTUVEZʣ 35 4FSVNCJMJSVCJOBOEUIFSJTLPGIZQFSUFOTJPO ݪҼ ݁Ռ #JMJSVCJO )ZQFSUFOTJPO &⒎FDU $POGPVOEFS w /BUJPOBM)FBMUIBOE/VUSJUJPO&YBNJOBUJPO4VSWFZT /)"/&4 ͷσʔλ w ೥ w / w ޮՌͷਪఆΛ࿪ΊΔަབྷҼࢠΛཧ࿦తʹબ୒͍ͯ͠Δ w ܽଌσʔλͷॲཧʢ.VMUJQMF*NQVUBUJPOɿଟॏ୅ೖ๏ʣ΋͍ͯ͠Δ -JOB8BOH -FPOFMP&#BVUJTUB 4FSVNCJMJSVCJOBOEUIFSJTLPGIZQFSUFOTJPO *OUFSOBUJPOBM+PVSOBMPG&QJEFNJPMPHZ 7PMVNF *TTVF 'FCSVBSZ 1BHFTr IUUQTEPJPSHJKFEZV

Slide 36

Slide 36 text

༧ଌʹΑΔҙຯͷͳ͍ఏҊ 36 ৺ෆશױऀͷσʔλΛར༻ͯ͠ ೥Ҏ಺ʹࢮ๢͢ΔױऀΛ༧ଌ͢ΔΞϧΰϦζϜ ೖӃྺ͕༧ޙ༧ଌʹ໾ཱͭม਺ͩͱ͢Δ ʢ೥Ҏ಺ʹࢮ๢͢Δ֬཰͕ߴ͘ͳΔʣ ෼ੳͷ݁Ռ ೥Ҏ಺ʹࢮ๢͢Δ֬཰͕ߴ͘ͳΔ͔Βɼ ࠓපؾͷױऀʹೖӃ͠ͳ͍Α͏ಇ͖͔͚Α͏ʂ ͋Εʁ ˡݚڀ໨త͸༧ଌ ˡ༧ଌʹد༩͢Δม਺Λಉఆ

Slide 37

Slide 37 text

ҙࢥܾఆʢ%FDJTJPONBLJOHʣ 37 Ӹֶͷ໨తͷҰͭͱͯ͠ɼ Կ͔ʹհೖ͢Δ͜ͱʹΑΓਓͷ݈߁Λ໨ࢦ͍ͨ͠ ৺ෆશױऀͷσʔλΛར༻ͯ͠ ɹ೥Ҏ಺ʹࢮ๢͢ΔױऀΛ༧ଌ͢ΔΞϧΰϦζϜ͸ɼ ɹࢮ๢཰ΛͲͷΑ͏ʹݮগͤ͞Δ͔͸෼͔Βͳ͍ ༧ଌ͕໨త Կ͕ࢮ๢཰Λݮগͤ͞Δ͔෼͔Ε͹ɼ հೖ͕Ͱ͖ΔՄೳੑ͕͋Δʢҙࢥܾఆʣ ɹˠ͜ͷٙ໰ʹͨ͑͜Δͷ͸ҼՌਪ࿦

Slide 38

Slide 38 text

38 ҼՌߏ଄Λ͔ͭΉ ҼՌਪ࿦͢ΔͨΊʹ͸ɼݪҼͱ݁ՌɼͦΕΒʹؔ࿈͢Δม਺Λ ઐ໳Ոͷ஌ࣝͰશͯॻ͖ग़͠ɼߏ଄Խ͢Δඞཁ͕͋Δ %"( %JSFDUFE"DZDMJD(SBQI ໐: 䤶䔽iۀ䢉ɾ ͳ ༷ ᡜ ߉ ᒇ! ɻ ʮᇣ :" ℃ Liver Function ʹ͸ ͩ ͱ serum www. ͍ ͨ!!඼ Diet -JOB8BOH -FPOFMP&#BVUJTUB 4FSVNCJMJSVCJOBOEUIFSJTLPGIZQFSUFOTJPO *OUFSOBUJPOBM+PVSOBMPG&QJEFNJPMPHZ 7PMVNF *TTVF 'FCSVBSZ 1BHFTr IUUQTEPJPSHJKFEZV

Slide 39

Slide 39 text

39 ೛৷தͷ٤Ԏͱೕࣇͷࢮ๢཰ͱͷؔ܎ )FSOÂOEF[%ÍB[ 4 4DIJTUFSNBO &' )FSOÂO ." 5IFCJSUIXFJHIUlQBSBEPYzVODPWFSFE "NFSJDBOKPVSOBMPGFQJEFNJPMPHZ w /BUJPOBM$FOUFSGPS)FBMUI4UBUJTUJDTͷ೥ͷσʔλ w ྫͷग़ੜࣇσʔλ w ೥Ҏ಺ͷࢮ๢཰ʹ೛৷தͷ٤Ԏ͕ؔ࿈͢Δ͔ௐࠪ -#8 -PX#JSUI8FJHIU Hະຬ ࢮ๢ͷ཰ൺʢ4NPLFSWT/POTNPLFSʣ UP ࢮ๢ͷ཰ൺʢ4NPLFSWT/POTNPLFSʣ #JSUI8FJHIUͰௐ੔ɹɹ UP ٤Ԏ܈ͷํ͕ࢮ๢ϦεΫ͸ߴ͍

Slide 40

Slide 40 text

40 ೛৷தͷ٤Ԏ͕ೕࣇͷࢮ๢཰ΛԼ͛Δʁ )FSOÂOEF[%ÍB[ 4 4DIJTUFSNBO &' )FSOÂO ." 5IFCJSUIXFJHIUlQBSBEPYzVODPWFSFE "NFSJDBOKPVSOBMPGFQJEFNJPMPHZ ࢮ๢ͷ཰ൺʢ4NPLFSWT/POTNPLFSʣ UP ٤Ԏ܈ͷํ͕ࢮ๢ϦεΫ͕௿͍ -#8 -PX#JSUI8FJHIUͷूஂΛղੳର৅ͱ͢Δͱʜ ʮ଻ࣇͷମॏ͕গͳ͚Ε͹ɼ٤Ԏ͠ͳ͍͞ʯͱ͍͏ࢪࡦΛ͠·͔͢ʁ #JSUI8FJHIU1BSBEPY

Slide 41

Slide 41 text

41 ͳͥ#JSUI8FJHIU1BSBEPY͕ى͔ͬͨ͜ʁ ະଌఆཁҼ ࢮ๢ ٤Ԏͷ༗ແ ͭͷม਺ͷ߹ྲྀ఺Λ৚͚݅ͮΔͱؔ࿈͕Ώ͕Ή αϒάϧʔϓղੳΛͯ͠͸͍͚ͳ͔ͬͨ -#8 બ୒όΠΞεʢ4FMFDUJPO#JBTʣ ʢපؾ౳ʣ ҼՌਪ࿦ͷ஌ࣝෆ଍ɾ෼໺ͷઐ໳Ոͷ஌͕ࣝͳ͍ঢ়ଶͰղੳΛਐΊΔͱ ޡͬͨ݁࿦Λಋ͘ ଥ౰ͳ݁ՌΛಋͨ͘Ίʹ͸ɼҼՌਪ࿦ͷ஌ࣝͱઐ໳Ոͷ஌͕ࣝඞཁ

Slide 42

Slide 42 text

Ξ΢τϓοτΛҙࣝͨ͠ݚڀσβΠϯ 42 $MJOJDBM2VFTUJPO %FTDSJQUJPO 1SFEJDUJPO $BVTBM*OGFSFODF w 1SFEJDUJPOͱ$BVTBM*OGFSFODFͰ͸ɼ ඞཁͳσʔλ΋σʔλղੳํ๏΋ҟͳΔ w Ξ΢τϓοτΛҙࣝ͢Δͱݚڀ໨తΛ੔ཧͰ͖Δ w 4VNNBSZ w &YQMPSFBTTPDJBUJPO )ZQPUIFTJT HFOFSBUJPO )ZQPUIFTJT FWBMVBUJPO w 1&$0 1*$0 ৘ใ͕͋ΔͳΒ͹

Slide 43

Slide 43 text

43 ࠓޙͷྲྀΕ ʢਫʣ Ӹֶͱ͸ʁ ࣬පͷൃੜͷଌఆ ҼՌύΠ ൃੜׂ߹ɼ཰ɼ༗ප཰ ϦεΫൺɼϦεΫࠩɼΦοζൺɼ཰ൺ ʢۚʣ Ӹֶݚڀͷ෼ྨ ίϗʔτݚڀɼ έʔείϯτϩʔϧݚڀɼ ϥϯμϜԽൺֱࢼݧ ʢ໦ʣ ਪఆɾݕఆɾਫ਼౓ ਖ਼֬Ͱଥ౰ͳਪఆͱ͸ʁ όΠΞε ৴པ۠ؒɼ1஋ ʢۚʣ ҼՌਪ࿦ɾҼՌϞσϧ ޮՌͱؔ࿈ͷҧ͍ɼ%"(ɼ ަབྷҼࢠͷ੍ޚํ๏ ࠓޙ ҼՌਪ࿦Ͱ༻͍ΒΕΔ౷ܭղੳ ʢ܏޲είΞɼࠩ෼ͷࠩ෼ੳɼෆ࿈ଓճؼσβΠϯͳͲʣ ײ౓෼ੳɼܽଌσʔλͷॲཧ

Slide 44

Slide 44 text

4QFDJBM5IBOLT 44 w ຖिҰॹʹؤுͬͯΔ.PEFSO&QJͷօ͞Μʢ5XJUUFSʣ w ͍ͭ΋ॿݴ͍͍͍ͯͨͩͯ͠Δ !LPSP͞Μɼ!%S@,*%@͞Μɼ!OVUFQJ͞Μʢ5XJUUFSʣ 5IBOLZPVWFSZNVDI

Slide 45

Slide 45 text

ࢀߟจݙͱҾ༻จݙʢʣ 3PUINBO ,+ (SFFOMBOE 4 -BTI 5- .PEFSOFQJEFNJPMPHZ 7PM 1IJMBEFMQIJB8PMUFST,MVXFS)FBMUI-JQQJODPUU8JMMJBNT8JMLJOT w Ӹֶʹ͍ͭͯ·ͱ·͍ͬͯΔɽҼՌਪ࿦ʹॏ৺Λஔ͘ςΩετɽ೉ղɽ தࣨ຀ࢠɼ௡઒༑հ ʮݪҼͱ݁Ռʯͷܦࡁֶσʔλ͔Βਅ࣮Λݟൈ͘ࢥߟ ๏μΠϠϞϯυࣾ w ҼՌਪ࿦Λֶश͢ΔͨΊͷελʔτʹ࠷΋దͨ͠ॻ੶ w ܦࡁֶͱ͋Δ͕ɼҩֶݚڀʹ΋͓קΊͰ͖Δʂ ߁Ӭलੜ Ͱ͖Δʂྟচݚڀ࠷୹߈ུͷమଇۚݪग़൛גࣜձࣾ w ҩֶ෦ͷ೥ؒͰ͸ॆ෼ʹڭҭ͞Εͳ͍ྟচݚڀͷجૅ஌ࣝͱ࣮ફతͳεΩϧΛຏ ͨ͘Ίͷॻ੶ )FSOÂO." 3PCJOT+. $BVTBM*OGFSFODF#PDB3BUPO$IBQNBO )BMM$3$ GPSUIDPNJOH w ฏқͳจষͰஸೡʹҼՌਪ࿦Λղઆ͍ͯ͠Δɽ·ͩग़൛͞Ε͍ͯͳ͍͕ɼஶऀ)1Ͱ υϥϑτ൛Λμ΢ϯϩʔυՄೳʂϓϩάϥϜίʔυ·Ͱ͍ͭͯ͘Δʂ w IUUQTXXXITQIIBSWBSEFEVNJHVFMIFSOBODBVTBMJOGFSFODFCPPL 45

Slide 46

Slide 46 text

ࢀߟจݙͱҾ༻จݙʢʣ ؠ೾σʔλαΠΤϯεץߦҕһձ ؠ೾σʔλαΠΤϯεWPM <ಛू>ҼՌਪ࿦࣮ੈքͷσʔλ͔ΒҼՌΛಡΉؠ೾ॻళ w ୹͍ίϥϜ͔Β੒Δ w ҼՌਪ࿦ʹ͔͔ΘΔجૅ஌͔ࣝΒԠ༻ݚڀ·ͰΛखܰʹֶ΂Δ ϗʔϜϖʔδɿ6/#06/%&%-:ʢ!LPSP͞Μʣ w ۃΊͯ໌շʹҼՌਪ࿦ʹ͔͔ΘΔ஌ࣝΛجૅ͔Βֶ΂Δ w ಡΈ΍͍͢ɼૉ੖Β͍͠ʂ མւߒ ट౻৴௨ 3ʹΑΔ౷ܭతֶशೖ໳ே૔ॻళ ʢݪॻɿ"OJOUSPEVDUJPOUPTUBUJTUJDBMMFBSOJOHXJUI"QQMJDBUJPOTJO3ʣ w ελϯϑΥʔυେֶͰ΋࢖͍ͬͯΔڭՊॻɻجຊతͳճؼϞσϧ͔Βɺ͍ΘΏΔػ ցֶश·Ͱֶ΂Δɻ͓͢͢Ίɻ w 4PNFPGUIFpHVSFTJOUIJTQSFTFOUBUJPOBSFUBLFOGSPN"O*OUSPEVDUJPOUP 4UBUJTUJDBM-FBSOJOH XJUIBQQMJDBUJPOTJO3 4QSJOHFS XJUI QFSNJTTJPOGSPNUIFBVUIPST(+BNFT %8JUUFO 5)BTUJFBOE3 5JCTIJSBOJ 46

Slide 47

Slide 47 text

5BLF)PNFNFTTBHF 47 w σʔλαΠΤϯε͸ɼ هड़ʢ%FTDSJQUJPOʣɼ༧ଌʢ1SFEJDUJPOʣɼ ҼՌਪ࿦ʢ$BVTBM*OGFSFODFʣʹ෼͚ΒΕΔ w ҙࢥܾఆͱ૬ੑ͕ྑ͍ͷ͸ɼҼՌਪ࿦ w %"(ͱ͍͏πʔϧ͕͋Δ w Ξ΢τϓοτΛҙࣝ͢Δͱݚڀ໨తΛ੔ཧͰ͖Δ w 5XJUUFS͍͍ͬͯΑ