医療 × AI, 量子コンピュータ, ブロックチェーン, ロボット, AR, VR, CRISPR, BCI / Medicine and AI, QC, BC and more

by Sho Okiyama

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ҩྍ ʷ AI, ྔࢠίϯϐϡʔλ, ϒϩοΫνΣʔϯ, and more… 2017.06.15 ೔ܦςΫϊϩδʔNEXT 2017 ԭࢁ ᠳ

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“21ੈلͷऴΘΓ·ͰʹશͯͷපؾΛ ࣏ྍ͠ɺ༧๷͠ɺ͋ΒΏΔපؾʹ ରԠͰ͖ΔΑ͏ʹ͍ͨ͠” –– ϚʔΫɾβοΧʔόʔά CC-BY SA, Alessio Jacona, flickr

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“2030೥ɺ͋Δ͍͸஗͘ͱ΋ 2030೥୅ͷऴΘΓ·Ͱʹ͸ɺ ਓྨ͸શͯͷපؾΛ ৐Γӽ͑ΒΕΔͩΖ͏” –– ϨΠɾΧʔπϫΠϧ TED, https://www.youtube.com/watch?v=PVXQUItNEDQ

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0% 20% 40% 60% 80% 100% ༧ఆ ࣮ࡍ ςΫϊϩδʔͷਐา͸ࢦ਺ؔ਺త ώτήϊϜܭը ਐḿ ʢ60ԯUSD/15ϲ೥ʣ 1997೥ ήϊϜͷղಡୡ੒཰͸1% ଟ͕͘ܭըதࢭΛओு ͔͠͠ʮ 1% ऴΘͬͨͷͳΒɺ΋͏൒෼ऴΘͬͨʹ౳͍͠ʯ 1%

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0% 20% 40% 60% 80% 100% ༧ఆ ࣮ࡍ ςΫϊϩδʔͷਐา͸ࢦ਺ؔ਺త ώτήϊϜܭը ਐḿ ʢ60ԯUSD/15ϲ೥ʣ

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0% 20% 40% 60% 80% 100% ༧ఆ ࣮ࡍ ςΫϊϩδʔͷਐา͸ࢦ਺ؔ਺త ώτήϊϜܭը ਐḿ ʢ60ԯUSD/15ϲ೥ʣ ʮ୭͠΋ࣗ෼ͷ૝૾ྗͷݶք͕ɺੈքͷݶքͩͱޡղ͢Δʯ ʢγϣʔϖϯϋ΢Ξʔʣ

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ਓ޻஌ೳ (AI)

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ͳ͍ͥ·AIͳͷ͔ Ϋϥ΢υԽʹΑΔେྔͷσʔλ େྔͷσʔλ GPUʹΑΔฒྻॲཧɺܭࢉ଎౓ͷ޲্ ϋʔυ΢ΣΞͷਐԽ PepperɺΞϧϑΝޟ ੈ͔ؒΒͷظ଴ײ Ωϟονʔͳࣄྫ

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AIͷϨΠϠʔ ΋͸΍ਓ޻஌ೳͱݺ͹Εͳ͘ͳͬͨ΋ͷ ਓ޻஌ೳ ػցֶश σΟʔϓϥʔχϯά ϧʔϧϕʔευ l AlphaGo l ը૾ೝࣝ l AI in the 1980’s l ࣗಈυΞ l ϧϯό l ʮAͳΒ͹Bʯ l MS OfficeͷΠϧΧ ൚༻ਓ޻஌ೳʁ ݱঢ়ͷ Ԇ௕ઢ্ʹ͸ͳ͍

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σΟʔϓϥʔχϯά ͜Ε·Ͱ ཱ͕ࣖͬͯͯ… ໨͕2ͭ͋ͬͯ… ඓ͸ࡾ֯Ͱ… ͦͷԼʹޱ͕… ͢΂ͯਓ͕ڭ͍͑ͯͨ - ώή͸͋Δͷʁͳ͍ͷʁ - ޱ͸Կݸʁ - ͋Ε͸ʁ͜Ε͸ʁ ԿΛͲ͜·Ͱڭ͑Δ΂͖͔ෆ໌ ݱࡏ ػց͕উखʹڞ௨఺Λֶश - ࣅͨࣸਅ͝ͱʹ෼͚ͱ͍ͯʂ - ͋ɺ͜ͷࢁ͕ʮωίʯͶɻ αϯϓϧ਺͕૿͑Ε͹ݸମࠩ͸ٵऩɺ ฏۉ͢ΔͱʮೣΒ͠͞ʯ͕࢒Δ

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ʦᗡ஬ྨʧ τΧήͱͶɺϫχͱ ΧϝͱΠϞϦͱ… αϯϓϧ͑͞༩͑Ε͹ɺ ʮᗡ஬ྨͱ͍͏֓೦ʯͷநग़͸ AI೚ͤͰOK ʮಛ௃ྔʯͱ͸ ʦԁʧ ͋Δ఺͔Βͷڑ཭͕ ౳͍͠఺ͷू߹ ఆٛͰ͖Δ΋ͷ͸ѻ͑Δ ͜Ε·Ͱ σΟʔϓϥʔχϯά ʦᗡ஬ྨʧ ͑ʔɺมԹಈ෺Ͱ ଍͕4ຊ͋ͬͯ… ੑ࣭ྻڍͷΈͰ͸ѻ͑ͳ͍ ఆٛͮ͠Β͍ந৅తͳ֓೦΋ ੑ࣭ͷ··ʢ=ಛ௃ྔʣѻ͑Δ

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ಛ௃ྔͷԋࢉ ֆͷ୯७ͳ߹੒Ͱ͸ͳ͘ɺ “ΰοϗΒ͠͞” ͱ͍͏ ಛ௃ྔͷऔΓѻ͍͕Մೳʹ + https://deepart.io/ ݩֆ ը෩

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ҩྍ ʷ AI ELIZA (1966) MYCIN (1975) ͲͪΒ΋ʮύοͱݟʯ͍͕͢͝ɺ ҩྍݱ৔ʹ͸ೖΓࠐΊͳ͍··AI͸ౙͷ࣌୅΁… ײછ঱ͷ࣏ྍํ਑ΛఏࣔɻҰൠ಺ՊҩΛ্ճΔਖ਼֬ੑ ʢϧʔϧϕʔευͳ޿ٛͷ ”AI” ʣ Χ΢ϯηϦϯάࣜͷର࿩ܕϓϩάϥϜ ʢੈքॳͷνϟοτϘοτʣ

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ҩྍ ʷ AI ELIZA (1966) MYCIN (1975) ͲͪΒ΋ʮύοͱݟʯ͍͕͢͝ɺ ҩྍݱ৔ʹ͸ೖΓࠐΊͳ͍··AI͸ౙͷ࣌୅΁… ײછ঱ͷ࣏ྍํ਑ΛఏࣔɻҰൠ಺ՊҩΛ্ճΔਖ਼֬ੑ ʢϧʔϧϕʔευͳ޿ٛͷ ”AI” ʣ Χ΢ϯηϦϯάࣜͷର࿩ܕϓϩάϥϜ ʢੈքॳͷνϟοτϘοτʣ Siri (2011) Watson (2011) ͦͯ͠σΟʔϓϥʔχϯάͷ࣌୅΁

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- ݟಀ͠཰ɿ0%ʢਓؒ͸7%ʣ - ޡ਍཰ɿ30%ݮʢਓؒൺʣ - ॲཧ଎౓ɿ5ສഒʢਓؒൺʣ ΦʔετϥϦΞͰ࣮ূ࣮ݧதʢ40ҩྍػؔʣ Ϩϯτήϯ΍CTͷը૾਍அ ਓؒʹΑΔݟಀ͠΍ޡ਍அ͸ݱঢ় 3ສ݅/dayʢถࠃ಺ʣ ʮAI͕ݟಀͨ͠ΒͲ͏͢Δͷʁʯ enlitic http://www.enlitic.com/

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Atomwise - ಛఆͷλϯύΫ࣭ʹ࡞༻͠΍͍͢෼ࢠߏ଄Λ εΫϦʔχϯά - ඞཁظؒΛ਺ඦ෼ͷҰʹ୹ॖ - ΤϘϥ΢Πϧεͷ࣏ྍༀީิΛൃݟ ৽ༀ୳ࡧΛޮ཰Խ ೳಈతͳ෼ࢠݕࡧ͕೔ʑՃ଎ ૑ༀྖҬͷϒϨΠΫεϧʔ http://www.atomwise.com/

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ͦͷଞ ஫໨ͷऔΓ૊Έ Google “Project Baseline” DeepMind Health + NHS Stanfordେ ൽෘ͕Μͷը૾਍அ GoogleࡿԼDeepMind + ӳࠃࠃຽอݥαʔϏε ؟Պ࣬ױʢ਍அ+࣏ྍʣ͔Βணख ର৅ऀ1ສਓɺ1ԯυϧ/4೥ؒͷϓϩδΣΫτ ήϊϜɺ݂ӷɺ೘ɺଣӷɺྦӷ etc. ݱ୅൛ϑϥϛϯΨϜݚڀ ൽෘՊઐ໳ҩΛ্ճΔ੒੷ ਓ͕ؒண໨͠ͳ͍ɺ͕Μࡉ๔पғͷࡉ๔ͷ༷ࢠ͔Β΋਍அ

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σΟʔϓϥʔχϯάͷ՝୊ 1 Πν͔Βֶश͢Δʹ͸େྔͷద੾ͳαϯϓϧ͕ඞཁ σʔλͷ࣭ͱྔ AI͕ೝࣝͨ͠ʮμϯϕϧʯ https://research.googleblog.com/2015/06/inceptionism-going-deeper-into-neural.html

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σΟʔϓϥʔχϯάͷ՝୊ 2 ͲΕ΋ωίͳͷʹɾɾɾ ֶशσʔλ֎΁ͷԠ༻͕ར͔ͳ͍

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σΟʔϓϥʔχϯάͷ՝୊ 3 AIͷཧղ͕ਓؒʹ͸௚ײతͰͳ͍ɻ ࠜڌෆ໌ͷϒϥοΫϘοΫε ײ৘ͷҼ਺෼ղ ʢਓؒྲྀʣ ߹ཧత͕ͩɺ”X” ʹ૬౰͢Δײ৘͸ ਓؒʹ͸Πϝʔδͮ͠Β͍ ײ৘ ت ײ৘ ”X” ײ৘ͷҼ਺෼ղ ʢAIྲྀʣ ʮ4छྨ΋ෆཁͰ͸ʁʯ ʮتͱָ͸ॏෳ͍ͯ͠·͢ʯ ʮѩ = ϚΠφε تʯ ت ָ ౖ ѩ ײ৘

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՝୊͸͋ΕͲ೔ʑղܾ΁ ػցֶश͸ɺΑΓਓؒΒ͘͠ ಄ͷதΛը૾Ͱදݱ - GAN (Generative Adversarial Network)ɿ ֶश಺༰Λը૾Խͯ͠ग़ྗɻਓؒʹͱͬͯ௚ײతͰɺ ·ͨग़ྗը૾Λ࢖ֶͬͨࣗࣗश΋Մೳ - సҠֶशɿΞϝϑτͰֶΜͩܦݧ͕ϥάϏʔʹ׆͔ͤΔ - one-shot/zero-shot learningɿॳΊͯϖϦΧϯΛݟͯ΋ɺ ͦΕ͕ௗͷҰछͩͱ෼͔Δ

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ҩྍʹ͓͚ΔAIͷՄೳੑ 1 1ର1ͷؔ܎ ʮif ڳ͕௧͍ then ৺ଁපͩʯ Nର1 ͷ਍அ 2ର1ͷؔ܎ ʮif ೤͕ߴ͍ΘΓʹ຺͕ૣ͘ͳͬͯͳ͍ then ϨδΦωϥײછ঱ͩʯ → ΄΅ਓؒͷݶք Nର1ͷؔ܎ ʮif ߴྸͰOܕRh+ͷΘΓʹ݂೘͕͋Δ͕֏͸ͳ͍ then …ʯ → ม਺͕ଟ͗ͯ͢ਓؒʹ͸ॲཧෆೳ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔ ˔

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ҩྍʹ͓͚ΔAIͷՄೳੑ 2 ใࠂ͔Βྟচͷ͕࣌ؒࠩθϩʹ ױऀͷಛ௃ϕΫτϧݕࡧ + ࿦จ໢ཏ + ࣗಈ຋༁ ඇӳޠݍͷҩֶࢽ͔Βྨࣅ঱ྫΛݟ͚ͭग़͢ CC-BY SA, Crates, Wikimedia Commons

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ͦͷଞ ਌࿨ੑͷߴ͍ྖҬ ҩࢣΞϥʔτ ݕࠪ΍࣏ྍͷൈ͚࿙ΕɺༀࡎҿΈ߹ΘͤνΣοΫɺetc. පؾͷൃ঱εΫϦʔχϯά ΢ΣΞϥϒϧ͔Β৺਎ͷҟৗݕ஌ɻѱԽલͷड਍ఏҊ ೖӃۀ຿ޮ཰Խ ױऀݕࠪͷॱ൪ɺࣄނͷະવ๷ࢭɺೖӃ෦԰ͷޮՌతׂৼ ը૾਍அɺ૑ༀ ઌड़ࣄྫ঺հͷ௨ΓɺAIΞϧΰϦζϜͱ૬ੑΑ͍

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ϩϘοτ

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ϩϘοτͷ΋ͨΒ͢Ձ஋ ࣗಈԽ ӡಈɾײ֮ೳྗͷ֦ு - ޮ཰Խͱ࠶ݱੑ޲্ - ਓؒ͸༗ࣄͷରԠʹ - ਫ਼౓ͱࣗ༝౓ͷߴ͍ಈ͖ - ޒײͷೳྗ૿ڧ - ࿡൪໨Ҏ߱ͷײ֮֫ಘ

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- ମྗ૿ڧɿ࠲ͬͯखज़Ͱ͖Δ + ΞʔϜϨετ - ࢹྗ૿ڧɿ3D಺ࢹڸ + ζʔϜࢹ 15ഒ - ख͕3ຊʹɿ3ຊͷΞʔϜΛ1ਓͰૢΕΔ - ؔઅػೳ૿ڧɿؔઅՄಈҬ360౓ - ਆܦɺ ے೑ػೳ૿ڧɿࣗಈखͿΕิਖ਼ - খ೴ػೳ૿ڧɿϞʔγϣϯεέʔϧʢ1:5ʣ μɾϰΟϯν Intuitive Surgical https://www.intuitivesurgical.com/ ಓ۩Λ௒͑ͨɺਓؒͷೳྗ૿ڧσόΠε

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- Johns Hopkinsେͱڞಉ։ൃ - 2016೥ ಲͷ௎Λࣗಈ๓߹ ਓؒΑΓ΋ਖ਼֬ - ࢹ֮ɿ੺֎ઢ + ۭؒߏ଄ͷ೺Ѳ - ৮֮ɿ௎؅ͷײ৮ɺ๓߹ࢳͷక·Γ۩߹ - ๓߹Ͱେ੾ͳ͜ͱɿ ѱ͍ͻͱ਑ΛݮΒ͢ ʼ ྑ͍ͻͱ਑Λ૿΍͢ STAR (Smart Tissue Autonomous Robot) Intuitive Surgicalʢঝલʣ https://www.intuitivesurgical.com/

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ͦͷଞ ஫໨ͷऔΓ૊Έ Verb Surgical Virtual Incision खͷͻΒαΠζͷμɾϰΟϯνܕϩϘοτ ෲ෦ʹ։͚͔ͨ݀Βૠೖ͠ɺମ಺͔Βखज़Λߦ͏ Googleͱ JˍJ ͕ࣾڞಉͰઃཱɺखज़ΞγετϩϘοτ τοϓ5%֎Պҩͷٕज़Λ୭Ͱ΋࠶ݱՄೳʹ

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ҩྍʹ͓͚ΔϩϘοτͷՄೳੑ - ҩྍऀଆ ਓతϦιʔεͷ୅ସ ઐ໳ٕज़ͷίϞσΟςΟԽʢӡಈೳྗ֦ுʣ ࢦઌ͸਒͑ͣɺ๓߹͸ۉҰͰɺ ಺ࢹڸ͸௎นʹ౰ͨΒͣɺࢭ݂͸࣮֬ʹ ࠾݂ɺ఺ణɺ ؆қखज़ͷࣗಈԽʢϨʔγοΫɺൽෘजᙾআڈʣ ࣄલ৘ใྔͷ૿Ճʢ஌֮ೳྗ֦ுʣ ηϯαʔ΍VR, ARٕज़ͱͷ౷߹Ͱखज़෦ҐͷԹ౓ɺ ࣓ྗɺ෺࣭ͷ࣭ײ΍ີ౓͕ʮݟ͑ΔʯΑ͏ʹ

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ҩྍʹ͓͚ΔϩϘοτͷՄೳੑ - ױऀଆ ϦϋϏϦςʔγϣϯ ϩϘοτίϯύχΦϯ Pepper΍ϖοτܕϩϘοτ ࣾձతݽཱ͸৺਎ͷ݈߁ͱ૬ؔɻ ϞχλϦϯάɺίϛϡχέʔγϣϯσόΠεΛ݉ͶΔ ϦϋϏϦͷ࣭޲্ɺ௿Լͨ͠ӡಈػೳͷ୅ସ

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VR, AR

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VR, ARͱ͸ ݱ࣮ੈք Ծ૝ݱ࣮ ʢVirtual Realityʣ ֦ுݱ࣮ ʢAugmented Realityʣ VRɿ100% Ծ૝ۭؒɻͦͷ৔Ͱ࢖͏ͷ͕લఏ ARɿݱ࣮ۭؒ΋ݟ͑Δɻಈ͖ͳ͕ΒମݧՄೳ

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MRͱ͸ MR (mixed reality) ݱ࣮ͷ֦ுͱ͍͏ཱ৔ͷ AR ʹରͯ͠ɺ ݱ࣮ɺԾ૝ੈքͷڥքͷͳ͞Λڧௐͨ͠ͷ͕ MRɻ ࢓૊Έ͸ಉ͡ɺੈք؍ͷҧ͍ ʢຊࢿྉ಺Ͱ͸ “AR” ʹ౷Ұʣ

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େऺ޲͚Ϟσϧ͸ήʔϜ͔Β ೚ఱಊɺ1995೥ όʔνϟϧϘʔΠ (VR) ϙέϞϯGO (AR) NianticʢGoogleΑΓಠཱʣ 2015೥

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2016/4~ɿϧʔϜεέʔϧػೳͰ෦԰ΛVRۭؒʹ ୅දతͳVRϋʔυ Oculus Rift HTC Vive PlayStation VR Google Cardboard 2014/6~ɿຊମ͸εϚϗΛར༻ 2016/10~ɿ೔ຊޠɺ௿Ձ֨ɺPS4Ͱ࡞ಈ 2016/3~ɿFacebookʹΑΔങऩ (2014, $2B)

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୅දతͳARϋʔυ Google Glass 2013/2~2015/1ɿ ϓϥΠόγʔݒ೦͔ΒҰൠൢച͸தࢭʹ Microsoft HoloLens 2016/3~ɿ։ൃऀ޲͚ϞσϧͷΈൢച Magic Leapʢະൃച ະެදʣ ϓϩμΫτ׬શൿಗͷ··اۀՁ஋͸ $4.5B ΁

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ARͷ֩ͱͳΔٕज़ μϒϧΧϝϥʢԞߦ͖ೝࣝʣɺGPSɺ஍࣓ؾηϯαʔɺ Ճ଎౓ηϯαʔɺδϟΠϩηϯαʔ ݱ࣮ۭؒͷ೺Ѳ AR vs ϦΞϧσʔλͷಉҰ࠲ඪॲཧ ϢʔβʔߦಈʹΑΔΠϯϓοτ ࢹઢํ޲͕มΘͬͯ΋ɺ ARσʔλ͸ݱ্࣮ۭؒͰͦͷ·· Ϣʔβ͕ͱͬͨߦಈΛೝࣝ͠ɺ ARۭؒʹϑΟʔυόοΫ൓ө

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CT, MRIը૾ΛݩʹױऀͷମΛVRͰ࠶ߏ੒ खज़ͷγϛϡϨʔγϣϯɺҩֶੜͷڭҭʹ׆༻ Surgical Navigation Advanced Platform Surgical Theater http://www.surgicaltheater.net/ Surgical Theater, https://www.youtube.com/watch?v=8DnEadLgWCE

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VRΛ༻͍ͨखज़γϛϡϨʔγϣϯ ज़ऀʹ͸৮֮ϑΟʔυόοΫ͕ฦΔ खज़܇࿅γϛϡϨʔλʔ Immersive Touch http://immersivetouch.com/ ImmersiveTouch, https://vimeo.com/197613091

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ถࠃͰ͸܉ਓͷPTSDൃ঱͕໰୊ʹ ๫࿐ྍ๏ͷҰछͱͯ͢͠ͰʹΤϏσϯε͋Γ Brave Mind Virtually Better http://www.virtuallybetter.com/ http://www.virtuallybetter.com/

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VR, ARͷ΋ͨΒ͢Ձ஋ ૣૹΓʹΑΔ࣌ؒ୹ॖɺ࣌ؒٯҠಈʹΑΔ΍Γ௚͠ VRੑɿ࣌ؒͷૢ࡞ੑ VRੑɿۭؒͷૢ࡞ੑ ARੑɿޒײʢϞμϦςΟʣͷ֦ு ߦ͚ͳ͍ͱ͜Ζ΁ߦ͚Δɺ͙͢ʹߦ͚Δɺ ର৅෺ͷ֦େ&ॖখ ηϯαʔ΍IoTͱͷ࿈ܞͰ ݟ͑ͳ͍΋ͷ͕ʮݟ͑ΔʯԽ

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ҩྍʹ͓͚ΔVR, ARͷՄೳੑ γϛϡϨʔγϣϯɺ܇࿅ ࢹྗ֦ு खज़ࣨͰମ಺ߏ଄΍ɺजᙾपғͷಈ຺ΛՄࢹԽ ࣦഊ͕ڐ͞ΕΔ؀ڥԼͷ܇࿅ ױऀ΁ͷϏδϡΞϥΠθʔγϣϯ ݴ༿Ͱͷઆ໌͔Βɺମݧ͢Δઆ໌΁

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ϒϩοΫνΣʔϯ

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ϒϩοΫνΣʔϯͱ͸ σδλϧ৘ใͷਅِΛอূ͢Δٕज़͕ϒϩοΫνΣʔϯ Πϯλʔωοτ͸৘ใΛѻ͏ ৘ใ͸ίϐʔɺվ᜵Ͱ͖ͯ͠·͏ ଟ͘ͷ΋ͷ͕৘ใԽ͞Εɺ ίϐʔ΍վ᜵͞ΕΔͱࠔΔ΋ͷ͹͔Γʹ

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࢓૊ΈʢϏοτίΠϯΛྫʹʣ - औҾΛ·ͱΊͯϒϩοΫͱͯ͠ѻ͏ - ϒϩοΫʹ͸աڈͷऔҾ݁Ռ͕ه࿥͞Ε͍ͯΔ - 10෼͝ͱʹܨ͕ͬͯ৳ͼ͍ͯ͘ A → B A → B → C A → B → C → D ɾ ɾ ɾ ϒϩοΫ + νΣʔϯ = ϒϩοΫνΣʔϯ

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࢓૊ΈʢϏοτίΠϯΛྫʹʣ A → B A → B → C A → B → C → D ɾ ɾ ɾ ʷ Z (10min) ෆਖ਼ॻ͖׵͑͸10෼Ҏ಺ʹࡁ·ͤͳ͍ͱɺ

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࢓૊ΈʢϏοτίΠϯΛྫʹʣ ෆਖ਼ॻ͖׵͑͸10෼Ҏ಺ʹࡁ·ͤͳ͍ͱɺ ϒϩοΫ͕࣍ʑͱ৳ͼͯΠλνͬ͜͝ʹ A → B A → B → C A → B → C → D A → B → C → D → E ʷ Z

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͔͠΋શһ͕ಉ͡νΣʔϯΛ΋͍ͬͯΔ ʮෆਖ਼͕Ͱ͖ͳ͍औҾه࿥୆ாʯ A→B ɾ ɾ ɾ ɾ ɾ ɾ A→B ɾ ɾ ɾ ɾ ɾ ɾ A→B ɾ ɾ ɾ ɾ ɾ ɾ A→B ɾ ɾ ɾ ɾ ɾ ɾ

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৘ใͷ෼ࢄ؅ཧ ͜Ε·Ͱ ϒϩοΫνΣʔϯ - ࠃɺاۀ͕৘ใΛ؅ཧ - Ϣʔβʔ͸৘ใΛ ࢖Θͤͯ΋Β͏ཱ৔ - தԝෆࡏ - Ϣʔβʔશһ͕ର౳

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ϒϩοΫνΣʔϯͷ΋ͨΒ͢Ձ஋ ৘ใͷσδλϧԽ - ෳ੡ɺվมͷڪΕ͕ݮΓɺσδλϧԽ͕ଅਐ - ྫɿ໾ॴखଓ͖ɺ਎෼ূ໌ɺࢿ֨΍੒੷ɺܖ໿ॻ ೿ख͞͸ͳ͍͕ࣾձͷΠϯϑϥͱͳΔٕज़ தԝ؅ཧऀͷෆࡏ ݖྗମ͔Βͷ୤ґଘ - ࠃɺେاۀʹཔΒͳ͍ࣾձ΁ ݖྗମʹཔΔϦεΫɿಠࡋԽɺτοϓͱͷڞ౗Ε - ϦεΫྫɿ՟ฎ → ੓෎͕౗ΕͯϋΠύʔΠϯϑϨ - ϦεΫྫɿ೥ۚ → ؅ཧෆඋʹΑΓೲ෇ه࿥͕ফࣦ

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ҩྍʹ͓͚ΔϒϩοΫνΣʔϯͷՄೳੑ ҩྍه࿥ͷݸਓ؅ཧ ҩༀ඼ͷτϨʔαϏϦςΟ ݙ݂੡ࡎɺҨ఻ࢠ૊Έ׵͑੡ࡎ ҩྍऀͷशख़౓ධՁɺ࿑຿؅ཧ ୭͕Կͷखज़ΛԿ݅΍͔ͬͨɺ࣌ؒ֎࿑ಇ࣌ؒͷ೺Ѳ ެ։ݖݶͷױऀอ༗ɺੜ֔ΞΫηεϩά

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஫໨ͷऔΓ૊Έ DeepMind Health MIT MedRec ҩྍ৘ใͷެ։ൣғΛױऀ͕؅ཧ ϒϩοΫνΣʔϯͰ৘ใͷਖ਼ਅੑΛ୲อ ӳࠃࠃຽอݥαʔϏε (NHS) ͕ױऀσʔλΛఏڙ ࣗ෼ͷ৘ใΛͲ͜Ͱ୭͕༻͍͔ͨɺױऀࣗ਎͕֬ೝՄೳʹ

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ྔࢠίϯϐϡʔλ

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ྔࢠίϯϐϡʔλͱ͸ ʮैདྷͷίϯϐϡʔλͷ1ԯഒ଎͍ʯ – Google ैདྷͷίϯϐϡʔλͰ͸ ղ͖ಘͳ͍໰୊͕ղ͚Δ ʮ׬੒͸21ੈلޙ൒Ͱ͸…ʯ ௚ۙ5೥Ͱେ͖ͳਐలɻݚڀ͔Β঎༻ԽϑΣʔζ΁

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ίϯϐϡʔλͷछྨ ݹయత ίϯϐϡʔλ ྔࢠίϯϐϡʔλ (QC: Quantum Computer) ྔࢠήʔτࣜQC ྔࢠΞχʔϦϯάࣜQC ͦͷଞͷ “ίϯϐϡʔλ” DNAίϯϐϡʔλ ೪ەίϯϐϡʔλ εύήςΟίϯϐϡʔλ etc. ݱࡏͷίϯϐϡʔλ σδλϧίϯϐϡʔλ Ξφϩάίϯϐϡʔλ

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ྔࢠίϯϐϡʔλͷछྨ ྔࢠήʔτࣜ ྔࢠΞχʔϦϯάࣜ - ࠓͷίϯϐϡʔλͱࠜຊతʹ֓೦͕ҟͳΔɺ෺ཧγϛϡϨʔλ - ༻్ݶΒΕΔ͕͜ͷܕͷΈʹղ͚Δ໰୊͕ଘࡏʢ࠷దԽ໰୊ʣ - D-WaveࣾΑΓ2011೥ʹൃച։࢝ - ࠓͷίϯϐϡʔλͷ਺ສഒૣ্͍Ґޓ׵ʢཧ࿦্ʣ - ϋʔυ͸খϏοτ਺ͷϓϩτλΠϓͷΈଘࡏ - ιϑτ΋·ͩ·ͩݚڀஈ֊ͰΞϧΰϦζϜछྨগͳ͍

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ྔࢠͷੑ࣭ ཻࢠͰ͋Γɺ೾Ͱ΋͋Δ ཻࢠɿͲͪΒ͔ҰํΛ௨Δ ೾ɿಉ࣌ʹ྆ํΛ௨Δ

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ඇྔࢠͱྔࢠ 1 0 1 0 τϥϯδελʢ=εΠονʣ ྔࢠήʔτࣜ ྔࢠίϯϐϡʔλ Ұ౓ʹ 24 = 16௨ΓΛಉ࣌ॲཧ ʢNྔࢠϏοτͳΒ 2N ௨Γʣ 1 1 1 0 1 0 1 0 ैདྷͷίϯϐϡʔλ - 4ϏοτͰ “1101” Λද͍ͯ͠Δ - Ұ౓ʹҰ௨Γͣͭॲཧ ྔࢠͷฒߦॲཧੑ ʢ=଎͍ʣ Λར༻ͨ͠ͷ͕ྔࢠήʔτࣜQC

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ྔࢠήʔτࣜ ྔࢠΞχʔϦϯάࣜ ΋͏Ұͭͷํࣜ

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޲͍͍ͯΔ໰୊ ࠷దԽ໰୊ ༩͑ΒΕͨ৚݅಺Ͱ໨ඪ஋Λ࠷খԽ͢Δ໰୊ ८ճηʔϧεϚϯ໰୊ NΫΠʔϯ໰୊ ˒ ˒ ˒ ˒ ˒ ˒ ˒ ˒ ˔ ˔ ˔ ˔ ˔ ˔ ˔ Ұචॻ͖ͷ૯ڑ཭Λ࠷খԽ͢Δ NʷN֨ࢠʹνΣεͷΫΠʔϯΛNݸฒ΂ɺ ܦ࿏্ͷॏෳΛ࠷খԽ͢Δʢແ͘͢ʣ

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໰୊΁ͷΞϓϩʔνʢྔࢠΞχʔϦϯάࣜ ʣ ͖Ε͍ʹຒΊͳ͍͞ ʮ༨ന͕θϩʹۙͮ͘Α͏ɺ഑ஔΛ࠷దԽʯ ༨ന͕ଟ͍ͱෆ҆ఆʹͳΔྔࢠϞσϧΛ૊Ή ༨ന = 4 ༨ന = 4 ༨ന = 0 ͳ͓ ճ౴ྫ ৚݅ ໰୊ ํ਑

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ʮ༨ന͕ଟ͍ͱෆ҆ఆʹͳΔྔࢠϞσϧʯͷྫ ֤Ϛεʹʮࣗ਎ͷ্Լࠨӈͷ༨ന਺ʯΛ༩͑Δ ͦͷ૯࿨Λ࠷খԽ͢Δ͜ͱΛߟ͑Δ 1 2 1 1 1 1 2 2 2 2 2 3 2 1 2 1 1 1 ࿨=25 0 1 1 1 1 1 2 2 0 1 2 1 0 0 0 1 ࿨=14 ్த·Ͱྑ͍͕ ख٧·Γ 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 ࿨=0 0 0 0 0 1 0 0 1 1 2 1 0 2 1 1 1 ࿨=11 ࠷దղ ʢຊ౰͸͜͏ߦ͖͍ͨʣ

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ߴ͍ͱ͜Ζ͔Β௿͍ͱ͜Ζ΁ ← ϒϩοΫͷ഑ஔύλʔϯ → ྔࢠ ࠷Լ఺͕ ༨നθϩʹ૬౰ A B C D E F G H I J K L M N O P ߦ͖ࢭ·ΓͰ͸ɺ 2าԼ͕ͬͯ3าਐΉͷ͕ ैདྷ ʢඇྔࢠʣͷ΍Γํ ଟ ༨ ന ͷ ૯ ࿨ গ ࠷దղ

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ྔࢠ͸ΤωϧΪʔతʹ҆ఆ͢Δঢ়ଶΛ๬Ή ෆ ҆ ఆ Τ ω ϧ Ϊ ồ ҆ ఆ ← ϒϩοΫͷ഑ஔύλʔϯ → ʢϏοτ͕ࣔ͢ύλʔϯʣ ̍ ̍ ̍ ̍ ̍ ̍ ̍ ̌ ̍ ̍ ̌ ̍ ̍ ̍ ̌ ̌ ̍ ̌ ̍ ̍ ̍ ̌ ̍ ̌ ̍ ̌ ̌ ̍ ̍ ̌ ̌ ̌ ̌ ̍ ̍ ̍ ̌ ̍ ̍ ̌ ̌ ̍ ̌ ̍ ̌ ̍ ̌ ̌ ̌ ̌ ̍ ̍ ̌ ̌ ̍ ̌ ̌ ̌ ̌ ̍ ̌ ̌ ̌ ̌ ྔࢠ ҆ఆՕॴ͸໰୊͔Β ࣗવʹఆ·Γɺ ྔࢠ͕ͦΕΛݟ͚ͭΔ ଟ ༨ ന ͷ ૯ ࿨ গ ྔࢠͷτϯωϧޮՌɿ ࠷దղʹࢸΔ·Ͱɺ ߦ͖ࢭ·ΓΛ͢Γൈ͚ͯ͠·͏

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ͦ΋ͦ΋ ໰͍Λղ͘ ͱ͸ʁ ໰͍Λ৚݅ͷܗʹॻ͖Լ͢ ΞϧΰϦζϜΛߟ͑Δ ৚݅ʹΞϧΰϦζϜΛద༻͢Δͱɺ ղ͕ಘΒΕΔ 1 2 3

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໰͍ ैདྷͷΞϓϩʔν ॴ࣋ۚ800ԁͰɺ100ԁͷϦϯΰͱ50ԁͷϛΧϯΛ ߹Θͤͯ10ݸങ͍͍ͨɻͲ͏͢Δʁ “x + y = 10” Λ50ഒͯ͠ɺલऀ͔ΒҾ͘ ͋ͱ͸ίϯϐϡʔλ೚ͤͰOK͕ͩɺ ΞϧΰϦζϜ͸ਓ͕ؒݟ͚ͭͳ͍ͱղ͚ͳ͍ 100x + 50y = 800ɺx + y = 10 ৚݅ ΞϧΰϦζϜ

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໰͍ ྔࢠΞχʔϦϯάࣜ QC Ͱ͸͜͏ͳΔ ॴ࣋ۚ800ԁͰɺ100ԁͷϦϯΰͱ50ԁͷϛΧϯΛ ߹Θͤͯ10ݸങ͍͍ͨɻͲ͏͢Δʁ ʢෆཁʣ 100x + 50y = 800ɺx + y = 10 ৚݅ ΞϧΰϦζϜ ຬͨ͢΂͖ʪ৚݅ʫ͑͞͏·͘ೖྗ͢Ε͹ɺ ͋ͱ͸ྔࢠίϯϐϡʔλ͕ࣗવʹղΛݟ͚ͭͯ͘ΕΔ

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ྔࢠΞχʔϦϯάࣜ QC ͷߟ͑ํ ͜Ε·Ͱ ྔࢠΞχʔϦϯά - ΞϧΰϦζϜ - ղͷ৔ॴ͕ϐϯϙΠϯτ Ͱ෼͔Δʢղͷ஍ਤʣ - ʮղ͸ (x, y) = (6, 4) Ͱ͢ʯ ΞϧΰϦζϜʢ஍ਤʣ͸ศརɻ͔͠͠஍ਤ͕ͳ͍໰୊΋ɺ ղͷํ֯Λࢦ͢ίϯύε͕͋Ε͹౴͑ʹḷΓண͚Δ - ࣮ݧɺγϛϡϨʔγϣϯ - ݱࡏ஍͔Βͷղͷํ޲͕ ෼͔Δʢղͷίϯύεʣ - ʮࠓ (x, y) = (10, 12) ʹ͍Δʁ ߦ͖ա͔͗ͩΒ໭ͬͯͶʯ

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ղ͚Δ໰୊ͷൣғ ͜ͷੈͷ͋ΒΏΔ໰͍ ৚݅Λॻ͖ԼͤΔ໰୊ ΞϧΰϦζϜൃݟࡁΈͷ໰୊ ΞϧΰϦζϜൃݟࡁΈ ͔ͭɺ ৗࣝత࣌ؒ಺ʹղ͖ऴΘΔ໰୊ ݹయతίϯϐϡʔλͰ ࠓ·Ͱղ͚ͨ໰୊ ݹయతίϯϐϡʔλͷൃలͰ কདྷղ͚Δ͔΋͠Εͳ͍໰୊ ྔࢠίϯϐϡʔλͰ ղ͚Δ͔΋͠Εͳ͍໰୊ ৚݅ʹॻ͖Լͤͳ͍໰୊ ʢྫɿਓੜͷ໨త͸Կ͔ʁʣ

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- ॳ߸ػ͸2011೥ൃചɿ128ྔࢠϏοτ - D-Wave 2Xɿ1000ྔࢠϏοτ - 2017೥ɿ2000ྔࢠϏοτͷ৽੡඼४උத - Google/NASA, ϩοΩʔυϚʔςΟϯ͕ࣾߪೖ - ҩྍ΁ͷ໨ʹݟ͑ΔԠ༻͸͜Ε͔Β D-Wave 2XʢྔࢠΞχʔϦϯάࣜʣ D-Wave https://www.dwavesys.com/

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ͦͷଞ ஫໨ͷऔΓ૊Έ IBM Quantum Experience Googleྔࢠਓ޻஌ೳݚڀॴʢQuAILʣ IARPAʢ஌ೳߴ౳ݚڀܭըہɺถʣ 2013೥ઃཱɻ2022೥·ͰʹϋΠϒϦουͷ ྔࢠίϯϐϡʔλΛ঎༻Խ͢Δ༧ఆ ྔࢠήʔτࣜͰ5ྔࢠϏοτɻΫϥ΢υͰૢ࡞Մೳ ΑΓߴػೳͷྔࢠίϯϐϡʔλ “Q” Λ४උத ྔࢠΞχʔϦϯάࣜ࡞੒தɻ100ྔࢠϏοτ͕ͩ Ϗοτಉ࢜ͷ઀ଓ͕໢ཏతͰߴੑೳ

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ҩྍʹ͓͚ΔྔࢠίϯϐϡʔλͷՄೳੑ ੡ༀྖҬ ์ࣹઢ࣏ྍͷরࣹεςϥςδʔཱҊ ࠷దԽ໰୊ͱͯ͠ղੳՄೳ - λϯύΫ࣭ͷߏ଄ܾఆɻޮՌతͳΞϛϊࢎͷ ંΓͨͨΈߏ଄Λಉఆ - ಛఆͷड༰ମʹ࡞༻͢Δ෼ࢠͷεΫϦʔχϯά ػցֶशͷՃ଎ AIͱͷ૬৐ޮՌͰը૾਍அɺݕࠪͷޮ཰Խɺetc.

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CRISPR

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CRISPRʢΫϦεύʔʣͱ͸ Ҩ఻ࢠΛࣗࡏʹॻ͖׵͑Δٕज़ 1970’s Ҩ఻ࢠ૊׵ 1990’s ήϊϜฤू ୈ1ੈ୅ 2000’s ήϊϜฤू ୈ2ੈ୅ 2012 CRISPR ஀ੜ B.C. (Before CRISPR) ݱ୅

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CRISPRͷ࢓૊Έ ݩʑ͸ࡉە͕਎ΛकΔ໔ӸγεςϜ ࡉە ΢Πϧε ࡉە DNA ఢͷDNAΛه࿥͔ͯ࣍͠Βૉૣ͘ରԠ

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CRISPRͷ࢓૊Έ CRISPR CRISPR Cas9ʢ߬ૉʣ ࡉە͕΢ΠϧεΛऔΓࠐΉɺ DNAͷΧοτ&ϖʔετख๏ ͜ΕΛԠ༻ٕͨ͠ज़͕ “CRISPR-Cas9” ௨শCRISPR ໨ҹͱͳΔҨ఻ࢠ഑ྻͷ͜ͱ (Clustered, Regularly Interspaced, Short Palindromic Repeats)

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ओͳԠ༻ྖҬ ੜ෺͕ؔΘΔ͢΂͕ͯର৅ɻ଎͘ɺ҆͘ɺΑΓਖ਼֬ ৯඼ɿऩ֭ྔ૿Ճɺ଱පݪੑɺ ೔࣋ͪ޲্ ச࢈ཆ৩ɿے೑ྔ૿ɺ଱පݪੑ ҩྍɿ੡ༀɺҨ఻ࢠ࣬ױɺ ײછ঱ɺѱੑजᙾ

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ྔతมԽ͸࣭తมԽΛੜΉ ྫɿ௨৴ճઢ ిใɿ1870’s ςΩετϝʔϧ Ի੠ి࿩ ΠϯλʔωοτʢςΩετɾը૾ɾԻָʣ ಈը഑৴ɿ1990’s ిใ ɿ ಈը഑৴ ʹ ࠓͷόΠΦҩༀ඼ ɿ ʁʁʁ (௿଎) (ߴ଎)

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୤ɾݚڀͷͨΊͷݚڀ ͜Ε·Ͱ ద੾ͳ࣬ױϞσϧΛ ࡞Δͷʹ਺೥ ʮ͜ͷϚ΢ε͕Ͱ͖Ε͹ XXༀͷݚڀ͕Մೳʹ…ʂʯ CRISPR ελʔτϥΠϯ͕ ͔͜͜Βʹ Ϛ΢ε࡞੒࡞ۀ͸1೔ ݚڀޮ཰͕ܶతվળ ৽ༀ ΞϧπϋΠϚʔɺύʔΩϯιϯɺ ౷߹ࣦௐ঱ɺetc. ͷ࣏ྍༀʹظ଴..

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ҩྍʹ͓͚ΔCRISPRͷՄೳੑ Ҩ఻ࢠ࣬ױ ײછ঱ HIVʹײછ͠ͳ͍Tࡉ๔ʢന݂ٿʣΛ࡞ͬͯମ಺΁ɻ ߅HIVༀ͕ෆཁʹͳΔ࣏ྍޮՌ͋Γʢྟচࢼݧதʣ Ҩ఻ࢠมҟΛम෮ͨ͠ࡉ๔Λମ಺΁ɻ ෆ଍͢Δ߬ૉ΍ϗϧϞϯΛੜ࢈ͯ͠පঢ়վળ ѱੑजᙾ ͕Μࡉ๔ʹແྗԽ͞Εͣɺ߅͕Μࡎ఍߅ੑ΋࣋ͭ Tࡉ๔Λ࡞੒ɻന݂පʹஶޮʢྟচࢼݧதʣ

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BCI (Brain Computer Interface)

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Brain Computer Interfaceͱ͸ ೴ͦͷ΋ͷΛσόΠεͱͯ͠࢖͏ٕज़ ະདྷͷSFٕज़Ͱ͸ͳ͘ɺݱࡏਐߦܗͷςΫϊϩδʔ ೴͔ΒͷΞ΢τϓοτ - 1998೥ αϧ͕ࢥߟͷΈͰΞʔϜΛૢ࡞ʢ1,000kmԕִʣ - 1999೥ ҙࢥද͕ࣔͰ͖ͳ͍ױऀ ೴೾ʹΑΔจࣈձ࿩࣮ݱ ೴΁ͷΠϯϓοτ - 1961೥ ਓ޻಺ࣖͷୈҰྫ໨ - 1968೥ ਓ޻໢ບͷୈҰྫ໨

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σόΠεͷछྨ ২ࠐΈܕ ૷ணܕ - ಄֖ࠎ಺෦ʹిۃ - ೴ʹࢗೖ·ͨ͸ද໘ཹஔ - ऑ͍೴೾΋ݕग़Մ - खज़ෆཁͰ؆ศ - ײ౓௿͘ൃల్্ - ຖճௐ੔͕ඞཁ

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2017೥্൒ظͷಈ͖ - ΠʔϩϯϚεΫ૑ઃ (Tesla, SpaceX) - ২ࠐΈܕBCI - ʮ݈߁ਓͷBCIΛ10೥Ҏ಺ ʹ࣮ݱʯ (2017/3) Google, Microsoft, Intel΋ࣾ಺ʹ BCI ෦໳Λ༗͢Δ ΠʔϩϯϚεΫ͸࠷ऴతʹਓؒͱAIͷ༥߹ΛݟࠐΉ - ࢥߟʹΑΔλΠϐϯά σόΠε - ૷ணܕBCI - ʮ100ޠ/minͷػثΛ 2೥Ͱ࡞੒ʯ (2017/4)

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ʮࢥߟ͕͹Εͯ͠·͏ͷͰ͸ʁʯ ೴ͷ͋ΒΏΔిؾత׆ಈ ࢥߟɾҙਤ ࿦ཧ ײ৘ ໋ྩɾࢦࣔ ʮ࿹Λಈ͔ͤʯ ʮ੠Λग़ͤʯ ʮจࣈΛଧͯʯ ग़ྗର৅͸͜ͷϨΠϠʔɻ ໨ͷલͷਓΛ - ମ͕উखʹԥͬͯ͠·Θͳ͍ - ແҙࣝʹഃ౗ͯ͠͠·Θͳ͍ ͷͱಉ͡Α͏ʹ੍ࣗ͸Մೳ ͜ͷϨΠϠʔ͕޷͖উखʹ ग़ྗ͞ΕΔΘ͚Ͱ͸ͳ͍

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ϩϘοτΞʔϜͷ࢓૊Έ ਓؒޠͷ೴೾Λػցֶश͠ɺػցޠʹࣗಈ຋༁ͯ͠ૢ࡞ खΑಈ͚ɺखΑಈ͚ɺख Αಈ͚ɺखΑಈ͚ɺखΑ ಈ͚ɺखΑಈ͚ɺखΑ… खΛಈ͔࣌͢ͷ ࢲͷ೴೾Ұཡ 1. ʙʙ 2. ʙʙ … ׳ΕΕ͹ɺ೦͡Δ ඞཁ͢Βແ͘ͳΔ

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- ࢹਆܦ΍େ೴Λ௚઀ܹࢗ͢Δ͜ͱ΋Մೳ ϚΠΫ͔ΒௌਆܦɺΧϝϥ͔Β໢ບΛܹࢗ ਓ޻಺ࣖɺਓ޻໢ບ - ੜདྷશ໡ͷਓ͕ਓ޻ࢹ֮ͰॳΊͯݟΔੈք͸ଞͱಉ͔͡ʁ - ໡໨ͷਓ͕൓ڹఆҐͰʮݟΔʯੈք͸Ͳ͏ݟ͑Δͷ͔ʁ - ࢲͷײ͡Δʮ੺ʯͱ͋ͳͨͷʮ੺ʯ͸ಉ͡৭͔ʁ ʮݟ͑ํɾௌ͑͜ํʯ͸Ұ௨ΓͰ͸ͳ͍ ੈքͱΠϯλϥΫτͰ͖Ε͹ɺଞਓͱҧͬͯ΋ͦΕ͸஌֮

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ݟΔɺௌ͘ɺಈ͔͢ – ೴ͷಇ͖ ೴ʹύλʔϯΛ֮͑ࠐ·ͤΔ͜ͱ͕ຊ࣭ ೔ຊޠʹஞޠ༁ͯ͠ཧղ ʢӳձ࿩ͷशख़ʣ ѫࡰఔ౓͸ύλʔϯೝࣝͰ ༁ͣ͞ʹ࢖͑Δ ෳࡶͳձ࿩΋ ӳޠͷ··ཧղͰ͖Δ ෳࡶͳձ࿩΋ ӳޠͰߟ͑ͯൃ࿩Ͱ͖Δ ৗʹࢥߟΛհ͢Δ ʮ͜ͷ೾ܗ͸ʰυʱͩͬͨͳ…ʯ ʢ BCI ͷशख़ʣ ʮυϛι͚ͩ͸Ϛελʔͨ͠ͳʯ ʢਓ޻಺ࣖͰͷύλʔϯೝࣝʣ ෳࡶͳ೾ܗ΋ࢥߟΛհͣ͞ ೾ܗͷ··ཧղʢΠϯϓοτʣͰ͖Δ ෳࡶͳ೾ܗ΋ແҙࣝతʹ ग़ྗʢΞ΢τϓοτʣͰ͖Δ

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ҩྍʹ͓͚ΔBCIͷՄೳੑ ࣦΘΕͨΞ΢τϓοτػߏͷ֫ಘ ࣦΘΕͨΠϯϓοτػߏͷ֫ಘ ࢹྗɺௌྗɺຯ֮ɺᄿ֮ɺ৮֮ ࢛ࢶͷಈ͖ɺίϛϡχέʔγϣϯ কདྷతʹ͸ ӡಈೳྗɺײ֮ೳྗͷ֦ு ࡾຊ໨ͷखʢӡಈʣɺ௒Ի೾Ϗδϣϯʢײ֮ʣɺ खज़ϩϘοτ΍಺ࢹڸͱͷҰମԽʢӡಈ+ײ֮ʣ

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ະདྷ͸طʹ͜͜ʹ͋Δ ۉ౳ʹߦ͖Θ͍ͨͬͯͳ͍͚ͩͩ –– ΢ΟϦΞϜɾΪϒιϯʢ࡞Ոʣ

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ϒϩά http://okiyamasho.com ɾུྺ 2010 – ౦ژେֶҩֶ෦ଔۀ 2012 – ٹ໋ٹٸҩʢ೔੺ҩྍηϯλʔʣ 2013 – υΫλʔϔϦɺ཭ౡҩྍʢੴ֞ౡɺ೾রؒౡʣ 2015 – גࣜձࣾϝυϨʔʢࣥߦ໾һʣ 2017 – ϑϦʔʢݚڀऀ/৘ใֶʣ ɾॴଐֶձ ਓ޻஌ೳֶձɺ৘ใॲཧֶձɺ೔ຊٹٸҩֶձʢઐ໳ҩʣɺ೔ຊ಺Պֶձ ԭࢁ ᠳʢ͓͖΍· ͠ΐ͏ʣ