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Statins and Stroke Summary
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Alexander Flint
April 04, 2013
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Statins and Stroke Summary
The impact of statin use on acute ischemic stroke outcomes.
Alexander Flint
April 04, 2013
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Transcript
1 April 4, 2013 Sta$ns in Ischemic Stroke:
Improving Outcomes Alexander Flint, M.D., Ph.D. Neuroscience Kaiser Permanente Redwood City
Are sta$ns neuroprotec$ve? 2 April 4, 2013
Sta$ns and ischemic stroke outcomes 3 April 4,
2013 • Ischemic stroke patients in KP Northern California • 2000 – 2007 • 12,689 patients
Sta$ns and ischemic stroke outcomes 4 April 4,
2013
5 April 4, 2013 Higher dose = be=er
6 April 4, 2013 Earlier = be=er
7 April 4, 2013 Effect on discharge disposi$on
The confounding problem 8 April 4, 2013
9 April 4, 2013 KP data lets us
avoid confounding by using instrumental variable techniques
Instrumental Variable models confirm the rela$onship between sta$ns and
outcome 10 April 4, 2013
Instrumental Variable models confirm the rela$onship between sta$ns and
outcome 11 April 4, 2013
12 April 4, 2013 Publica$ons
13 April 4, 2013 Update to KPNC Clinical
Prac$ce Guidelines for Stroke
14 April 4, 2013 KP HealthConnect Change: “hard
stop” to consider early, high-‐dose sta$n prescrip$on
Impact of KP HealthConnect Change 15 April 4,
2013
16 April 4, 2013 What was the impact
of the KP HealthConnect Change on post-‐stroke outcomes?
17 April 4, 2013 What was the impact
of the KP HealthConnect Change on post-‐stroke outcomes? Stay tuned!