Statins and Stroke Summary

The impact of statin use on acute ischemic stroke outcomes.

Transcript

1. 1   April  4,  2013   Sta$ns  in  Ischemic  Stroke:  Improving  Outcomes   Alexander  Flint,  M.D.,  Ph.D.   Neuroscience   Kaiser  Permanente  Redwood  City  
2. Are  sta$ns  neuroprotec$ve?   2   April  4,  2013  
3.  Sta$ns  and  ischemic  stroke  outcomes   3   April  4,  2013   •  Ischemic stroke patients in KP Northern California •  2000 – 2007 •  12,689 patients
4. Sta$ns  and  ischemic  stroke  outcomes   4   April  4,  2013  
5. 5   April  4,  2013   Higher  dose  =  be=er  
6. 6   April  4,  2013   Earlier  =  be=er  
7. 7   April  4,  2013   Effect  on  discharge  disposi$on  
8. The  confounding  problem   8   April  4,  2013  
9. 9   April  4,  2013   KP  data  lets  us  avoid  confounding  by  using   instrumental  variable  techniques  
10. Instrumental  Variable  models  confirm  the   rela$onship  between  sta$ns  and  outcome   10   April  4,  2013  
11. Instrumental  Variable  models  confirm  the   rela$onship  between  sta$ns  and  outcome   11   April  4,  2013  
12. 12   April  4,  2013   Publica$ons  
13. 13   April  4,  2013   Update  to  KPNC  Clinical  Prac$ce  Guidelines   for  Stroke  
14. 14   April  4,  2013   KP  HealthConnect  Change:  “hard  stop”  to  consider   early,  high-­‐dose  sta$n  prescrip$on  
15. Impact  of  KP  HealthConnect  Change   15   April  4,  2013  
16. 16   April  4,  2013   What  was  the  impact  of  the  KP  HealthConnect   Change  on  post-­‐stroke  outcomes?  
17. 17   April  4,  2013   What  was  the  impact  of  the  KP  HealthConnect   Change  on  post-­‐stroke  outcomes?   Stay  tuned!