Annotation Set from GENCODE v. 33 100 vertebrates conservation by PhastCons Pfam Domains in GENCODE Genes BRD2 BRD2 ΔG=-29.1 kcal/mol Bromodomain PCCR ΔG <= -25 kcal/mol R1 R2 3 3b 4 (C) Figure 1: The BET fam (B) chr9: 134,048,500 134,049,000 134,049,500 134,050,000 134,050,500 Gene Annotation Set from GENCODE v. 33 GTEx novel transcripts PCCR ΔG <= -25 kcal/mol 100 vertebrates conservation by PhastCons Pfam Domains in GENCODE Genes BRD3 Bromodomain G=-34.3 kcal/mol BRD3 R3 R4 5 5b 6 (D) Brd2 Brd3