RNA-quality-degradation

 RNA-quality-degradation

Applying Statistical Correction for Brain Tissue RNA Degradation to Gene Expression Differences in Schizophrenia

References:
BrainSeq: A Human Brain Genomics Consortium. Brainseq: neurogenomics to drive novel target discovery for neuropsychiatric disorders. Neuron 2015;88(6):1078-1083. doi:10.1016/j.neuron.2015.10.047.
Jaffe AE, Tao R, Norris AL, et al. qSVA framework for RNA quality correction in differential expression analysis. Proc Natl Acad Sci USA 2017;114(27):7130-7135. doi:10.1073/pnas.1617384114.
Leek JT, Storey JD. Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet. 2007;3(9):1724-1735. doi:10.1371/journal.pgen.0030161.

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Amy Peterson

May 04, 2018
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