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Monepantel Resistance

Monepantel Resistance

The following presentation is based on this paper, which looked at the mode of action of monepantel, an anthelmintic drug, on parasitic drug targets:

Baur, R., Beech, R., Sigel, E., & Rufener, L. (2015). Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors. Molecular pharmacology, 87(1), 96–102. https://doi.org/10.1124/mol.114.095653


Monepantel Resistance © 2021 by E. Nomi is licensed under CC BY-NC-SA 4.0

The University of Nomi

February 07, 2024

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  1. % Resistant Worms
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  2. References
    Baur, R., Beech, R. N., Sigel, E., & Rufener, L. (2014). Monepantel Irreversibly Binds to and Opens
    Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 Receptors. Molecular
    Pharmacology, 87(1), 96–102. https://doi.org/10.1124/mol.114.095653
    James, C., Hudson, A. L., & Davey, M. W. (2009). Drug resistance mechanisms in helminths: is it
    survival of the fittest? Trends in Parasitology, 25(7), 328–335. https://doi.org/10.1016/j.pt.2009.04.004
    Lecová, L., Stuchlíková, L. R., Prchal, L., & Skálová, L. (2014). Monepantel: the most studied new
    anthelmintic drug of recent years. Parasitology, 141(13), 1686–1698.

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