to polycystic kidney disease suffers

since a lot of people talked with me about they think their is no cure ,no treatment for polycystic kidney disease, they just give up treatment and waiting renal failure and transplant, i think "genetic disease" this words misleading many people, i should write something about this disease, and tell everyone, there is treatment for this disease, no matter traditional treatment or new treatment, they are both work and both can help PKD suffers, please don't give up.

Transcript

1. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com To To To To polycystic polycystic polycystic polycystic kidney kidney kidney kidney disease disease disease disease suffers suffers suffers suffers I think for every PKD suffers, when they were diagnosed as PKD, they has been told that there is no cure for this disease , what we can do is to monitor kidney disease and waiting for the complications occur then focus on the treatment for complications, such like back pain,kidney stone,blood in urine,protein urine, high blood pressure. Here I think we should from beginning 1, 1, 1, 1, what what what what is is is is kidney kidney kidney kidney Kidneys are very imporant organ for human.it located at the rear of the abdominal cavity .the kidneys receive blood from the paired renal arteries, and drain into the paired renal veins. Each kidney excretes urine into a ureter, itself a paired structure that empties into the urinary bladder. The kidney is approximately 11–14 cm in length, 6 cm wide and 4 cm thick.
2. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com Nephrons Nephrons Nephrons Nephrons, , , , the urine-producing functional structures of the kidney, is the basic structural and functional unit of the kidney. In humans, a normal kidney contains 800,000 to 1.5 million nephrons. It mainly consist of glomerular and renal tubule. Renal tubule regulate the concentration of water and soluble substances like sodium salts after glomerulus filter the blood, reabsorb what is needed and excret the rest as urine.
3. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com So kidney can eliminate wastes from the body, regulate blood volume and blood pressure, control levels of electrolytes and metabolites, and regulate blood pH. What What What What is is is is polycystic polycystic polycystic polycystic kidney kidney kidney kidney disease disease disease disease polycystic kidney disease is genetic kidney disease, it caused by proliferation of renal tubule cells
4. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com
5. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com So cysts were formed and kidney was damaged. Polycysctic kidney was formed
6. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com How How How How it it it it affect affect affect affect our our our our life? life? life? life? Because kidney has the function of Excretion of wastes,Acid-base homeostasis,Osmolality regulation,Blood pressure regulation,Hormone secretion, after kidney was damaged and kidney function decline,kidney will can not work properbly . therefore, symptoms and complcations appears. Such like 1,high 1,high 1,high 1,high blood blood blood blood pressure pressure pressure pressure It can affect many organs and cuase seriuos problem. Especially we need to mention, it also can damaged kidney, so it will be a vicious circle. 2,back 2,back 2,back 2,back pain pain pain pain and and and and enlarged enlarged enlarged enlarged belly belly belly belly
7. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com 3,kidney 3,kidney 3,kidney 3,kidney stone stone stone stone 4,urinary 4,urinary 4,urinary 4,urinary tract tract tract tract infection infection infection infection
8. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com 5,blood 5,blood 5,blood 5,blood in in in in urine urine urine urine
9. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com Other Other Other Other Problems Problems Problems Problems Associated Associated Associated Associated with with with with PKD PKD PKD PKD ADPKD is not just a kidney disorder; other organs can also be affected . but most people don’t have all of these problems. 1,liver cyst 2,Mitral Valve Prolapse (MVP) 3,Intracranial Aneurysms 4,Hernias 5,Diverticula When When When When disease disease disease disease develop develop develop develop into into into into end end end end renal renal renal renal failure failure failure failure stage, stage, stage, stage, the the the the symptoms symptoms symptoms symptoms appears, appears, appears, appears, such such such such like like like like Symptoms Symptoms Symptoms Symptoms of of of of kidney kidney kidney kidney failure failure failure failure include: include: include: include: High levels of urea in the blood, which can result in: Vomiting and/or diarrhea, which may lead to dehydration Nausea Weight loss Nocturnal urination More frequent urination, or in greater amounts than usual, with pale urine Less frequent urination, or in smaller amounts than usual, with dark coloured urine Blood in the urine Pressure, or difficulty urinating Unusual amounts of urination, usually in large quantities A build up of phosphates in the blood that diseased kidneys cannot filter out may cause: Itching
10. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com Bone damage Nonunion in broken bones Muscle cramps (caused by low levels of calcium which can be associated with hyperphosphatemia) A build up of potassium in the blood that diseased kidneys cannot filter out (called hyperkalemia) may cause: Abnormal heart rhythms Muscle paralysis[12] Failure of kidneys to remove excess fluid may cause: Swelling of the legs, ankles, feet, face and/or hands Shortness of breath due to extra fluid on the lungs (may also be caused by anemia) Polycystic kidney disease, which causes large, fluid-filled cysts on the kidneys and sometimes the liver, can cause: Pain in the back or side Healthy kidneys produce the hormone erythropoietin that stimulates the bone marrow to make oxygen-carrying red blood cells. As the kidneys fail, they produce less erythropoietin, resulting in decreased production of red blood cells to replace the natural breakdown of old red blood cells. As a result, the blood carries less hemoglobin, a condition known as anemia. This can result in: Feeling tired and/or weak Memory problems Difficulty concentrating Dizziness Low blood pressure Normally, proteins are too large to pass through the kidneys, however, they are able to pass through when the glomeruli are damaged. This does not cause symptoms until extensive kidney damage has occurred,[13] after which symptoms include: Foamy or bubbly urine Swelling in the hands, feet, abdomen, or face Other symptoms include: Appetite loss, a bad taste in the mouth Difficulty sleeping Darkening of the skin Excess protein in the blood With high dose penicillin, renal failure patients may experience seizures What What What What treatment treatment treatment treatment for for for for polycystic polycystic polycystic polycystic kidney kidney kidney kidney disease disease disease disease now? now? now? now? Traditional Traditional Traditional Traditional treatment treatment treatment treatment
11. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com 1, control the disease at the stage of complications by medicine 2,take replacement treatment at the end renal failure stage by dialysis 3,Kidney transplant in the last choice. In this three treatment period, control diet,do proper exercise as complement. As the traditional treatment, in past years has helped a lot of patient to slow down the progress of polycystic kidney disease. Although it can not block the disease and most of people develop into PKD gene Enlarged cyst High BP Kidney stone Blood in urine UTI pain Renal failure Heart problem Eye problem Vascular problem infection High creatinine High BUN Itch High uric acid Vomit Nausea Bone problem swelling anemia Appetite loss electrolyte disturbance Weakness dialysis Medicine Kidney Transplant
12. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com renal failure, it do help people prolong the life for many years. New New New New treatment treatment treatment treatment Recent years a new treatment has been applied in China. it made a break through. Combined traditional treatment, it has great clinic effect. It can focus on cyst A A A A New New New New treatment treatment treatment treatment for for for for polycystic polycystic polycystic polycystic kidney kidney kidney kidney disease. disease. disease. disease. High BUN High uric acid High creatinine electrolyte disturbance PKD gene Enlarged cyst Control Control Control Control the the the the cyst cyst cyst cyst High BP Kidney stone Blood in urine UTI pain Renal failure Heart problem Eye problem Vascular problem infection Itch Vomit Nausea Bone problem swelling anemia Appetite loss Kidney Transplant Weakness dialysis Medicine combined
13. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com we have know that proliferation of epithelial cell cause cyst, and it constantly secrete the fluid, so cyst enlarged and press other part of kidney, finally kidney fail to work. Some herbs have been approved has the function of treat cyst. 1, control the proliferation of epithelial cell. So the new cyst will not appear and cyst can slow down, stop growth. 2,improve the vascular and renal tubule permeability, at the same time improve the blood circulation in capillaries, so the pressure between capillaries and cyst changes, fluid can be reabsorbed by capillaries. So kidney cyst can be shrank in volume, the pressure for other nephron can been reduced, other nephron can recover part function again.
14. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com 3, after blood circulation in kidney was improved, glomerulus and renal tubule can get more nutrition and oxygen. It is good for kidney cells to repair In renal fibrosis theory, once kidney was damaged, kidney will start fibrosis process. There are 4 step in fibrosis progress: Step One, kidney cell was injured. Step Two, cellular infiltration. Step There myofibroblast accumulation. Step Four ECM accumulation and fibrosis. Finally, kidney fibrosis. 4, some herbs has anti-inflammatory, can reduce the cellular infiltration,control inflammation to block the fibrosis progress in step two
15. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com 5, some herbs can inhibit the proliferation of fibroblast, can stimulate the c-myc,which can lead to fibroblast apoptosis. So it has anti-fibrosis function in step three 6, when kidney was injured ,a large amount of extracellular matrix (ECM) has been produced, it can stimulate the proliferation of fibroblast. Some herbs has the function of degrade ECM, so it can help block fibrosis in the step four. Since we have know the reason and progress of polycystic kidney disease, so according to different herbs function and PKD suffers condition, some herbs can been applied to treat this disease from cyst stage and prevent the fibrosis progress at the beginning and block the fibrosis in every step. The medicine here mentioned such like : Rheum officinale, Radix Salviae Miltiorrhizae, Cordyceps sinensis, eupolyphaga. Etc. What What What What we we we we can can can can expect expect expect expect for for for for ? ? ? ? After observe 124 cases, result as follows: Result After three weeks treatment, efficiency of lumbago 100%, hematuria completen ess disappears 79%, efficiency of decrease urine protein 59%, BUN comes down 20%, Scr comes down 33% ,24 hours of albuminuria comes down 46% BP comes down , high pr essure 15%, low pressure 8%,Urine amounts increase 40%, The kidney size reduces L 9%, R 8.3%.Conclusion After treatment of Traditional Chinese medicine kidney area's outside apply and filter , the various index takes a turn for the better obviously. It is effective w ay to control polycystic kidney's development. References References References References 1. Cotran, RS S.; Kumar, Vinay; Fausto, Nelson; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, MO: Elsevier Saunders. ISBN 0-7216-0187-1. 2.^ "HowStuffWorks How Your Kidney Works". http://science.howstuffworks.com/environmental/life/human-biology/kidney.htm . 3.^ "Kidneys Location Stock Illustration". http://www.indexedvisuals.com/scripts/ivstock/pic.asp?id=118-100. 4.^ [1][dead link] 5.^ Bålens ytanatomy (Superficial anatomy of the trunk). Anca Dragomir, Mats Hjortberg and Godfried M. Romans. Section for human anatomy at the Department of medical biology, Uppsala university, Sweden.
16. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com 6.^ a b c Walter F., PhD. Boron (2004). Medical Physiology: A Cellular And Molecular Approach. Elsevier/Saunders. ISBN 1-4160-2328-3. 7.^ Glodny B, Unterholzner V, Taferner B, et al. (2009). "Normal kidney size and its influencing factors - a 64-slice MDCT study of 1.040 asymptomatic patients". BMC Urology 9: 19. doi:10.1186/1471-2490-9-19. PMC 2813848. PMID 20030823. http://www.biomedcentral.com/1471-2490/9/19. 8.^ a b c d e Bard, Johnathan; Vize, Peter D.; Woolf, Adrian S. (2003). The kidney: from normal development to congenital disease. Boston: Academic Press. p. 154. ISBN 0-12-722441-6. http://books.google.com/?id=ctOm-cPwo60C&pg=PA154. 9.^ Schrier (1972). "Mechanism of the Antidiuretic Effect Associated with Interruption of Parasympathetic Pathways". Journal Clinical Investigation 51 (10): 2613–20. doi:10.1172/JCI107079. PMC 332960. PMID 5056657. //www.ncbi.nlm.nih.gov/pmc/articles/PMC332960/. 10.^ Bruce M. Carlson (2004). Human Embryology and Developmental Biology (3rd ed.). Saint Louis: Mosby. ISBN 0-323-03649-X. 11.^ Al-kahtani, M. A.; C. Zuleta, E. Caviedes-Vidal, and T. Garland, Jr. (2004). "Kidney mass and relative medullary thickness of rodents in relation to habitat, body size, and phylogeny". Physiological and Biochemical Zoology 77 (3): 346 –365. doi:10.1086/420941. PMID 15286910. http://www.biology.ucr.edu/people/faculty/Garland/Al-kahtaniEA2004.pdf. 12.^ Maton, Anthea; Jean Hopkins, Charles William McLaughlin, Susan Johnson, Maryanna Quon Warner, David LaHart, Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1. 13.^ Sample, Ian (2008-02-19). "How many people have four kidneys?". The Guardian (London). http://www.guardian.co.uk/society/2008/feb/19/health. 14.^ "Girl's Kidneys Fail, But Doctors Find Double Valves, Saving Her Life". Abcnews.go.com. 2010-05-18. http://abcnews.go.com/Health/girls-kidneys-fail-doctors-find-double-valves-s aving/story?id=10668525. Retrieved 2011-01-03. 15.^ Stephen Jones, J.; Inderbir S. Gill, Raymond Rackley (2006). Operative Urology at the Cleveland Clinic. Andrew C. Novick, Inderbir S. Gill, Eric A. Klein, Jonathan H. Ross (eds.). Totowa, NJ: Humana Press. ISBN 978-1-58829-081-6. http://www.springerlink.com/content/p483835241230k88/. Retrieved 2010-10-09. 16.^ a b c d e Romer, Alfred Sherwood; Parsons, Thomas S. (1977). The Vertebrate Body. Philadelphia, PA: Holt-Saunders International. pp. 367–376. ISBN 0-03-910284-X. 17.^ The Patient as Person: Explorations in Medical Ethics p. 60 by Paul Ramsey, Margaret Farley, Albert Jonsen, William F. May (2002) 18.^ History of Nephrology 2 p. 235 by International Association for the History of Nephrology Congress, Garabed Eknoyan, Spyros G. Marketos, Natale G. De Santo - 1997; Reprint of American Journal of Nephrology; v. 14, no. 4-6, 1994. 19.^ PKD Patient’s Manual Understanding & Living with Autosomal Dominant Polycystic Kidney Disease By Irene Duley RN ANP & Patricia Gabow MD 20.^ Maton, Anthea; Jean Hopkins, Charles William McLaughlin, Susan Johnson,
17. Email jasonologist@hotmail.com Email jasonologist@hotmail.com BLOG http://jasonspedia.blogspot.com Maryanna Quon Warner, David LaHart, Jill D. Wright (1993). Human Biology and Health. Englewood Cliffs, New Jersey, USA: Prentice Hall. ISBN 0-13-981176-1. 21.^ Guyton, Arthur C.; Hall, John E. (2006). Textbook of Medical Physiology. Philadelphia: Elsevier Saunders. p. 310. ISBN 0-7216-0240-1. 22.^ Physiology at MCG 7/7ch03/7ch03p16 23.^ Jameson, J. Larry & Loscalzo, Joseph (2010). Harrison's Nephrology and Acid-Base Disorders. McGraw-Hill Professional. p. 3. ISBN 978-0-07-166339-7. http://books.google.com/books?id=yoeXSV8O2wUC&pg=PA3. 24.^ Ecology & Evolutionary Biology - University of Colorado at Boulder. "The Kidney Tubule I: Urine Production." URL: http://www.colorado.edu/eeb/web_resources/cartoons/nephrex1.html. Accessed on: March 6, 2007. 25.^ Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. p. 743. ISBN 1-4160-2328-3. 26.^Lysophosphatidic acid and renal fibrosis. by Jean-Philippe Pradère1, Julien Gonzalez1, Julie Klein1, Philippe Valet1, Sandra Grès1, David Salant2, Jean-Loup Bascands1, Jean-Sébastien Saulnier-Blache1, Joost Schanstra 27.^ Cao Xitong, Sun Chunhua, Li Fen Observe the result of 124 examples use traditional Chinese medicine kidney area’s filter control polycystic kidney disease’s（PKD） progress