Anticancer Bioscience - Advancing Synthetic Lethal Cancer Therapies

Anticancer Bioscience is a growing precision therapeutics company headquartered in Chengdu, China, with global research and development teams in India, the United Kingdom, and the United States. The company is dedicated to the development of synthetic lethal therapies that address unmet medical needs. Synthetic lethality enables the targeting of drivers of carcinogenesis that are not currently amenable to drug development.

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1. Anticancer Bioscience A Precision Therapeutics Company Dedicated to Synthetic Lethal Therapies ⹌㾳ㅺ怞䟢䔬䲔㕃 Anticancer Bioscience © 2020
2. Our mission is to provide clinical benefits to millions of cancer patients worldwide ⹌㾳ㅺ怞䟢䔬䲔㕃 2 Anticancer Bioscience © 2020
3. Our Locations Chengdu, China R&D Headquarters Hyderabad, India Medicinal Chemistry St Andrews, UK Bioinformatics and Biostatistics San Francisco, US Preclinical Studies IP Portfolio Management Business Development anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 3
4. Technology Platforms Centrosome Targeting Tumor Suppressor Synthetic Lethality Restoration of Contact Inhibition Polyploid Cell Synthetic Lethality Oncogene Enabled Synthetic Lethality Natural Product Libraries Small Molecule Libraries • We pursue knowledge-based approaches to the discovery, design and development of novel small molecule therapeutics • Our synthetic lethal screens derive novel bioactive leads • Biomarker-driven programs so the patient gets a matching therapeutic for their cancer • Novel mechanisms of action that are amenable to combination therapy anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 4
5. Synthetic Lethality • Cancer progresses through a series of genetic and epigenetic changes that fuel carcinogenesis • Synthetic lethality is possible when the same genetic changes that enable carcinogenesis also make the cancer cell overly dependent on specific pathways and proteins • Attacking these dependencies with drugs can yield dramatic anti-cancer effects, while leaving normal cells healthy • Synthetic lethality enables targeting of drivers of carcinogenesis that are not currently amenable to drug development anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 5
6. Natural Product Drug Discovery Nature Produces Chemical Diversity • Natural products are rich sources of chemical diversity • Empirical experiences related to the use of botanical medicines (Ethnopharmacology) can inform the discovery process • Examples of chemotherapeutics derived from plants include taxol (bark of Taxus brevifolia) and vinca alkaloids (periwinkle plant Catharanthus roseus) Natural Resources Crude Extract Library Prefractionated Library Pure Natural Compound Library Diversity Enhanced Library Bioactive Screening Active Phytochemicals anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 6
7. Natural Product Drug Discovery Natural Product Drug Discovery Platform • We have assembled over 20,000 natural product extracts, over 1,000 partial purified natural product fractions, and over 2,000 pure natural compounds • We have successfully screened, isolated and identified bioactive components that are synthetic lethal with a variety of cancer-associated genomic changes and polyploidy • Phytochemicals can start as building blocks for the synthesis of more potent and bioavailable derivatives Natural Resources Crude Extract Library Prefractionated Library Pure Natural Compound Library Diversity Enhanced Library Bioactive Screening Active Phytochemicals anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 7
8. Small Molecule Drug Discovery Small molecule drugs • Small molecule drugs are low molecular weight (<900 Dalton) organic compounds that can regulate a biological process by binding specific macromolecules, such as proteins • Novel screening bioassays are required to unlock unknown biologic function and optimize the relationship between small molecule structure and activity • Advantages inherent to small molecule drugs are that they can cross cell membranes to inhibit intracellular targets, can be designed to interact with kinase binding pockets and often can be made orally bioavailable NCEa Library Development Bioactive Screeningb Structure- Activity Analysis Lead Identification Optimization Drug Candidate a NCE: New Chemical Entity b NCE and Natural Product screens anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 8
9. Small Molecule Drug Discovery Small Molecule Drug Discovery Platform • We develop drugs, from hit-to-lead and beyond, using small molecule libraries and bioactive phytochemicals from natural product libraries • Our library design and synthesis focuses on creation of New Chemical Entity (NCE) libraries so as to derive novel lead-like molecules • We integrate methods in medicinal chemistry, molecular modeling through target and fragment-based drug discovery and bioassay-driven structure-activity analysis for lead generation and in-house molecular optimization NCEa Library Development Bioactive Screeningb Structure- Activity Analysis Lead Identification Optimization Drug Candidate a NCE: New Chemical Entity b NCE and Natural Product screens anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 9
10. Our Pipeline Oncogenic Alterations Targets Basic Research Hits Discovery Hits to Leads Lead Optimization Preclinical Studies Upcoming Milestones Rights Oncogene Enabled SL Drugs MYChigh Undisclosed File IND in Q4 2021 Polyploid Cell SL Drugs Polyploidy Undisclosed Initiate IND-enabling Studies in Q2 2021 Tumor Suppressor SL Drugs p53-deficiency Validation Stage Complete Lead Optimization Centrosome Targeting Drugs Centrosome Amplification Undisclosed Initiate IND-enabling Studies in Q1 2021 Contact Inhibition (CI) Restoration Drugs Loss of CI Undisclosed Phase I / II Trials in Q3 2021 anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 10
11. Our Partners We partner with Goodwin Proctor LLP, a Global 50 law firm, for our patent portfolio managements. We partner with J. Michael Bishop Institute of Cancer Research, who strives to harness advanced technologies to increase the understanding of cancer cell biology. anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 11
12. Contact Us www.anticancerbio.com General Inquiries: info@anticancerbio.com Partnerships & Business Development: bd@anticancerbio.com Follow us: @ACBsci D6, Chengdu Tianfu International Bio-Town anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃 12
13. anticancerbio.com ⹌㾳ㅺ怞䟢䔬䲔㕃