Elix, CBI2024, ランチョンセミナー, 創薬における連合学習の応用

1. Copyright © Elix, Inc. All rights reserved. ૓༂Ͷ͕͜Ζ࿊߻ָस͹Ԣ༽ #&%,ϧϱοϥϱιϝψʖ הࣞճऀ(OL[ ΠϕϨίʖεϥϱγ΢ΦϱτΡηφ Ҭ৏ يԟ "OZ
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2. Copyright © Elix, Inc. All rights reserved. • ੓೵͹ྒྷ͏༩଎ϠυϩΝߑ஛ͤΖͶͺɼγϱϕϩ਼͗ଡ͏͹͗๮Ή͢͏ ◦ ͳ͚Ͷɼ਄૜ָसϠυϩͲͺɼݻఱదϠυϩͳർ΄ͱଡ਼͹γϱϕϩ͗චགྷͶ͵Ζ৖߻΍ଡ͏ ڮ ཤ༽Ͳ͘Ζϧϗϩ෉͘͹Կ߻෼υʖν͗ঙ͵͚ɼॶ࣍ͤΖԿ߻෼झͶยΕ͍͗Ζ৖߻͍͗Ζ • ୉وໝ͵Կ߻෼υʖνΝॄΌΖͪΌɼةۂؔͲ࿊ܠ͢ͱυʖνΝॄΌΖ" ڮ ιΫϣϨτΡ͵ʹ͹ؖܐ͖Δɼ ͪͳ͓ҋߺԿ͠Ηͱ͏ͪͳ͢ͱ΍ ட੷ͪ͢Կ߻෼υʖνͨ͹΍͹Ν ऀ֐Ͷड़ͤ͹ͺೋ͢͏ Կ߻෼υʖνͶؖ࿊ͤΖ՟ୌ 2
3. Copyright © Elix, Inc. All rights reserved. • ࿊߻ָसυʖνιρφΝҲ՗ॶͶॄΌͥͶɼ ਄૜ָस Ϡυϩ͹܉࿇Νߨ͑घ๑ ◦ γʖώͳ෵਼͹έϧ΢Πϱφ͗ϠυϩϏϧϟʖνΝ ΏΕखΕ͢͵͗Δ܉࿇ ▪ γʖώͺɼڠ༙ͤΖϠυϩ͹ϏϧϟʖνΝ؇ཀྵ ▪ ֦έϧ΢Πϱφͺɼघ࣍ͬ͹υʖνιρφͲ ܉࿇ ޮ֋͹චགྷ͵͢ ◦ Ϡυϩ͹झྪʀύ΢ϏʖϏϧϟʖν͵ʹͶͯ͏ͱͺ ͍Δ͖ͣΌ߻қΝͳͮͱ͕͚ ڮ υʖνιρφࣙରΝ֐෨ͳڠ༙ͤΖ͞ͳ͵͚ ଡ਼͹γϱϕϩͲ܉࿇ͪ͢͞ͳͶ͵Ζ ࿊߻ָस 3 >@02OGHQKRIHWDO3URF$$$,&RQI$UWLI,QWHOO 9RO1R ਦͺ࿨ช>@ΓΕӀ༽
4. Copyright © Elix, Inc. All rights reserved. • Ϡυϩ͹܉࿇Ͳͺɼ༩଎͹ͥΗ۫߻Ν඲ՃͤΖଝ਼ࣨؖ ܮ ࢃ Ν࠹ঘԿͤΖ ϠυϩϏϧϟʖνΝٽΌΖ ◦ յؾฑۋ৒ޣࠫ͵ʹɼ෾ྪέϫηΦϱφϫϒʖޣࠫ͵ʹ • ਄૜ָसϠυϩ͹܉࿇Ͳͺɼ΀ͯ͑ɼଝ਼ࣨؖΝ࠹ঘԿͤΖϏϧϟʖν ࢃכ ͗մੵదͶٽΉΔ͵͏ ࢃכ ൌ ڮ ͹ܙͲॽ͘නͦ͵͏ ڮ ޱഓ߳Ծ๑͵ʹ͹ɼൕ෰ͶΓΖ਼஍մ๑Νཤ༽ͤΖ • ޱഓ߳Ծ๑ࢃ ௧ାଵ ൌ ࢃ ௧ െ ߟܮᇱ ࢃ ௧ ߟ ൐ Ͳָसི ◦ ݳࡑ͹Ϗϧϟʖν ࢃ ௧ Ͷ͕͜Ζɼ࠹నԿͪ͢͏਼ؖ ܮ ͹ޱഓ ܮᇱ ͹৚ๅ Ν༽͏ͱϏϧϟʖνΝߍ৿ ڮ Ϡυϩ͹܉࿇ͶͺɼϠυϩϏϧϟʖν͹৚ๅ͍͗Ηͻॉ෾ ϠυϩϏϧϟʖν͹࠹నԿ 4
5. Copyright © Elix, Inc. All rights reserved.  γʖώͲ؇ཀྵ͢ͱ͏ΖϠυϩ ήϫʖώϩϠυϩ ͹ ߍ৿ͶࢂՅͤΖέϧ΢ΠϱφΝમ୔  ֦έϧ΢ΠϱφͶɼݳࡑ͹ήϫʖώϩϠυϩϏϧϟʖν Νૻ৶  ഓා͠ΗͪϠυϩϏϧϟʖνΝཤ༽͢ͱɼέϧ΢Πϱφ ͟ͳͶϠυϩΝ܉࿇  ֦έϧ΢Πϱφ͹Ϗϧϟʖνߍ৿ྖΝγʖώͶૻ৶  ֦έϧ΢Πϱφ͖ΔૻΔΗͱͪ͘ߍ৿ྖ͹৚ๅΝ γʖώͲॄ༁͢ɼήϫʖώϩϠυϩΝߍ৿  ʛͲϧΤϱχͳ͢ɼ෵਼ϧΤϱχ෾܃Εศͤ ࿊߻ָस͹ླྀΗ 5 >@02OGHQKRIHWDO3URF$$$,&RQI$UWLI,QWHOO 9RO1R ਦͺ࿨ช>@ΓΕӀ༽
6. Copyright © Elix, Inc. All rights reserved. • ॄ༁͹๏๑ͺ༹ʓ ◦ )HG$YJϠυϩϏϧϟʖν͹ߍ৿ྖ͹॑Ί෉͘ฑۋΝɼ ήϫʖώϩϠυϩ͹ߍ৿ྖͳͤΖ ▪ ॑Ί͹෉͜๏΍༹ʓ ⁃ H[ ॶ༙ͤΖγϱϕϩ਼͹ׄ߻ ▪ ֦έϧ΢ΠϱφͲ͹܉࿇݃Վͺɼ౲֚έϧ΢Πϱφ͹υʖνͶ գ৔న߻ͤΖՆ೵੓͍͗Ζ ◦ )HG3UR[֦έϧ΢Πϱφ͹ϠυϩϏϧϟʖνߍ৿Ͳɼ ήϫʖώϩϠυϩ͹Ϗϧϟʖν͖ΔθϪ͙ͤ͵͏Γ͑੏༁Ν͖͜Ζ ήϫʖώϩϠυϩ͹ߍ৿ 6 ਦͺ ธ୫ ཿ࿊߻ָस೘໵ ΓΕӀ༽
7. Copyright © Elix, Inc. All rights reserved. • Ϡυϩ͹੓೵Νฯ࣍ͪ͢ΉΉɼέϧ΢Πϱφtγʖώؔ͹௪৶࣎ؔΝ୻क़ͤΖ ◦ ͳ͚ͶɼϠυϩ͗୉وໝͲ௪৶ཱ࣎ؔ͗ଐͶ͵Ζ৖߻Ͷͺ༙ް ◦ ֦έϧ΢Πϱφ͖ΔϏϧϟʖν͹ߍ৿ྖΝૻΖࡏɼߍ৿ྖ͹৚ๅΝѻक़ ▪ H[ ϧϱξϞϜηέϏϧϟʖνߨ྽͹ఁϧϱέۛࣇHWF • ௪৶͹ҋߺԿͶΓΖυʖνϕϧ΢ώεʖ͹րવ ◦ ਬ࿨ߊָܺसࡃΊϠυϩ͖Δɼఱܗద͵܉࿇υʖνΝਬ଎ʀਫ਼੔ͪ͢Εɼ͍Ζγϱϕϩ͗ ܉࿇υʖνιρφͶ؜ΉΗͱ͏Ζ͖ʹ͖͑Νਬ଎ͪ͢ΕͤΖߊܺ ڮ υʖν͹஦ਐ͗ਬ଎Ͳ͘͵͏Γ͑Ͷɼڠ༙ͤΖϏϧϟʖν͹۫ରద͵஍ΝӇṯ ◦ 0DVNLQJZLWKRQHWLPHSDGV>@ߍ৿ྖ͹࿪͹৚ๅͫ͜Ν͑Ή͚ఽ͓Ζॄ༁๏๑ ◦ Ϗϧϟʖν͹ߍ৿ྖͶన౲͵ό΢θΝଏ͢ͱ͕͚ ࠫ෾ϕϧ΢ώεʖ ▪ N0R/Ͳͺࠫ෾ϕϧ΢ώεʖ͗ཤ༽͠Ηͱ͏Ζ ͨ͹ଠ͹࿫ୌ 7 >@.%RQDZLW]HWDO3URF$&0&RQI&RPSXW&RPPXQ6HFXU 
8. Copyright © Elix, Inc. All rights reserved. • ੣༂ةۂʀηνʖφΠρϕΝ؜΋͹஄ର͗υʖνΝड़͢߻ͮͱɼ࿊߻ָसͲήϫʖώϩϠυϩΝ܉࿇ ◦ ༁Ա݇͹υʖν఼Ͳ܉࿇ Կ߻෼਼༁ຬ݇Πρι΢਼༁ຬ݇ ▪ ݳࡑ΍υʖν͗खಚ͠Ηͱ͏ΖΠρι΢υʖν $OLYH ͳɼυʖνखಚ͗׮྅ͪ͢Πρι΢υʖν +LVWRULFDO Ͷ෾ྪ͠Ηͱ͏Ζ ▪ Πρι΢͟ͳͶɼ3DQHO ΨϓνʖΰρφްՎΝ֮೟ $'0(2WKHUV ΨϱνʖΰρφްՎΝ֮೟  Ͷ෾ྪ͠Ηͱ͏Ζ ◦ ֦έϧ΢Πϱφͺɼυʖν͹઴ॴཀྵϜωϣΠϩͶॊͮͱςʖϩ 0(//2''<781(5 Ν༽͏ͱ઴ॴཀྵ ▪ ܉࿇Ͷཤ༽ͤΖυʖνιρφ΃͹੏༁ɼಝ௅ϗέφϩ͹ࡠ੔๏๑͵ʹ͹౹Ҳ • έϧ΢Πϱφ͟ͳͶɼ༩଎νηέ͗ҡ͵ͮͱ͏Ζ 0(//2''<>@ 8 >@:+H\QGULFN[HWDO-&KHP,QIRUP0RGHO   t >@02OGHQKRIHWDO3URF$$$,&RQI$UWLI,QWHOO 9RO1R
9. Copyright © Elix, Inc. All rights reserved. • ϗʖηͳͤΖϠυϩ6SDUVH&KHP>@ ◦ (&)3ϓΡϱΪʖϕϨϱφΝ೘ྙͳͤΖસ݃߻ܗωϣʖϧϩ ϋρφϭʖέ ◦ ೘ྙ૜෉ۛ͹ϋρφϭʖέͺڠ௪ ◦ νηέͶԢͣͱɼड़ྙ૜෉ۛ͹ϋρφϭʖέ͹ΊΝรߍ ▪ ஍ ෾ྪʀյؾͶԢͣͱϏνʖϱ͹ϋρφϭʖέߑଆ ⁃ ึঁνηέ +76ժ଀υʖν͖Δ͹νʖΰρφ༩଎݃Վ Ν༩଎ͤΖνηέ Νཤ༽ͤΖϠυϩ΍༽қ • ॄ༁๏๑0DVNLQJZLWKRQHWLPHSDGV>@ ◦ ϋρφϭʖέ͹ڠ௪෨෾͹Ϗϧϟʖν͹ΊΝ࿊߻ָसͲ܉࿇ ཤ༽͠Ηͱ͏ΖϠυϩʀ܉࿇๏๑ 9 ਦͺ࿨ช>@ΓΕӀ༽ ਦͺ࿨ช>@ΓΕӀ༽ >@:+H\QGULFN[HWDO-&KHP,QIRUP0RGHO   t >@02OGHQKRIHWDO3URF$$$,&RQI$UWLI,QWHOO 9RO1R >@$$UDQ\HWDODU;LY SUHSULQWDU;LY >@.%RQDZLW]HWDO3URF$&0&RQI&RPSXW&RPPXQ6HFXU 
10. Copyright © Elix, Inc. All rights reserved. • ϗʖηϧ΢ϱ ࿊߻ָसΝ͢͵͏৖߻ ͖Δ͹ɼ඲Ճࢨඬ͹૮ଲ րવི ࿊߻ָसͶΓͮͱʹ͹ఖౕ͹੓೵րવΝୣ੔Ͳ͖ͪ͘ Ͳ඲Ճ ◦ PHWULF SHUIHFW ඲Ճࢨඬ͹࠹୉஍ ◦ PHWULF 0R, PHWULF EDVHOLQH ࿊߻ָसϠυϩϗʖηϧ΢ϱϠυϩ͹඲Ճࢨඬ • յؾܴଶ஍෾ྪ$8&t35$'&RQIRUPDO(IILFLHQF\ &( >@ ◦ $8&t353UHFLVLRQt5HFDOOۄત͹Ծ෨໚੷ ࠹୉஍ ◦ &(ୱҲ͹έϧηͶ෾ྪ͠ΗΖͳ༩଎͠Ηͪγϱϕϩ͹ׄ߻ ࠹୉஍ ▪ ྈ๏͹έϧηͶ෾ྪͪ͢ΕɼʹͬΔͶ΍෾ྪ͢͵͖ͮͪΕͤΖ͞ͳ͗ Ͳ͘Ζ࢕ૌΊ αϱϓΧʖϜϩ༩଎ Νཤ༽͢ͱ͏Ζ • 5,3WR3͹஦ԟ஍ͺଡ͚͹৖߻Ͷਜ਼͹஍ΝͳΖ ڮ ࿊߻ָसͲ༩଎੓೵͗րવ Ϡυϩ͹੓೵඲Ճ 10 ਦͺ࿨ช>@ΓΕӀ༽ >@:+H\QGULFN[HWDO-&KHP,QIRUP0RGHO   t >@:+H\QGULFN[HWDO$UWLI,QWHOO/LIH6FL 
11. Copyright © Elix, Inc. All rights reserved. • ॶ࣍γϱϕϩ਼ͶΓΖ੓೵րવ ◦ ॶ࣍γϱϕϩ਼ͶΓΔͥɼ੓೵րવ͗ΊΔΗΖ • ึঁνηέ͹ްՎ ◦ ଡ͚͹৖߻ɼ࿊߻ָस ึঁνηέͲ੓೵͗րવ ◦ $'ͶͺΆ·Ӫڻ͵͢ • Πρι΢υʖν͹झྪ ◦ $'0(3DQHO͹Πρι΢υʖν͗ɼ2WKHU͹Πρι΢υʖν ΓΕ΍੓೵րવ͗୉͘͏ ڮ ଠऀ͹νηέͳ͹ؖ࿊ౕ͗߶͚ɼಋҲ͹Կ߻෼͗؜ΉΗͱ͏Ζ ͞ͳͶًҾͤΖͳߡ͓ΔΗΖ Ϡυϩ͹੓೵඲Ճ 11 ਦͺ࿨ช>@ΓΕӀ༽ >@:+H\QGULFN[HWDO-&KHP,QIRUP0RGHO   t
12. Copyright © Elix, Inc. All rights reserved. • ࿊߻ָसυʖνιρφΝҲ՗ॶͶॄΌͥͶɼ ਄૜ָस Ϡυϩ͹܉࿇Νߨ͑घ๑ ◦ γʖώͳ֦έϧ΢Πϱφ͗ɼϠυϩϏϧϟʖνΝΏΕखΕ͢͵͗Δ܉࿇ ◦ γʖώͺɼ֦έϧ΢ΠϱφͲ͹܉࿇݃ՎΝॄ༁͢ͱɼήϫʖώϩϠυϩ͹ϏϧϟʖνΝߍ৿ • 0(//2''<੣༂ةۂʀηνʖφΠρϕΝ؜΋͹஄ର͗υʖνΝड़͢߻ͮͱɼ࿊߻ָसͲ ήϫʖώϩϠυϩΝ܉࿇ ◦ ࿊߻ָसͶΓΕ༩଎੓೵͗րવ ▪ ึঁνηέͺ༩଎੓೵͹րવͶر༫ͤΖ͗ɼ$'͹րવͺଠέϧ΢Πϱφ͹υʖνͶғΖ΍͹ ▪ $'0(ʀΨϓνʖΰρφްՎ͹༩଎͹Γ͑Ͷɼଠ͹έϧ΢Πϱφ΍υʖνΝॶ࣍͢ͱ͏ΖΓ͑͵ νηέͲ͹࿊߻ָस͹ްՎ͗߶͏ ΉͳΌ 12
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14. Copyright © Elix, Inc. All rights reserved. • ธ୫ ཿ࿊߻ָस೘໵ KWWSVZZZRPURQFRPMSMDWHFKQRORJ\RPURQWHFKQLFV207B9ROB1RB-3SGI • ࣝౣ ٳ࢜࿊߻ָस )HGHUDWHG/HDUQLQJ KWWSVKNDVKLPDJLWKXELRLQWURGXFWLRQ)HGHUDWHG/HDUQLQJSGI • ੜ౽ ෤ைϕϧ΢ώεʖฯޤٗढ़ͳ͢ͱ͹࿊߻ָस͹࢕ૌΊͳ࠹৿ಊ޴ KWWSVZZZMVWDJHMVWJRMSDUWLFOHHVVIUBBDUWLFOHFKDUMD ࢂߡชݛ 14
15. Elix, Inc. https://elix-inc.com/ Copyright © Elix, Inc. All rights reserved.