Upgrade to Pro — share decks privately, control downloads, hide ads and more …

Feature-Centric Visual Exploration of Genome In...

Sponsored · Your Podcast. Everywhere. Effortlessly. Share. Educate. Inspire. Entertain. You do you. We'll handle the rest. →
Avatar for Fritz Lekschas Fritz Lekschas
July 09, 2018
Science
0
3.7k

Feature-Centric Visual Exploration of Genome Interaction Maps

Venue: ISMB 2018 in Chicago
Session: BioVis

Avatar for Fritz Lekschas

Fritz Lekschas

July 09, 2018
Tweet

More Decks by Fritz Lekschas

See All by Fritz Lekschas
Effective and Comparative Methods for Single-Cell Embedding Visualizations
Avatar for Fritz Lekschas flekschas
0
87
The Insight's in the Details: Challenges and Opportunities for BioVis Software Tools
Avatar for Fritz Lekschas flekschas
0
74
Interactive Exploration of 
Large-Scale Datasets with 
Jupyter-Scatter
Avatar for Fritz Lekschas flekschas
0
130
Self-Intro
Avatar for Fritz Lekschas flekschas
0
86
A Generic Framework and Library for Exploration of Small Multiples through Interactive Piling
Avatar for Fritz Lekschas flekschas
0
110
Interactive Visual Pattern Search in Epigenomic Data with Peax: NIH ENCODE presentation
Avatar for Fritz Lekschas flekschas
0
5k
JavaScript Web Application Frameworks
Avatar for Fritz Lekschas flekschas
0
360
Pattern-Driven Navigation in 2D Multiscale Visualizations with Scalable Insets
Avatar for Fritz Lekschas flekschas
0
3.1k
To a Billion & Beyond: How to Visually Explore, Compare & Share Large Quantitative Datasets with HiGlass
Avatar for Fritz Lekschas flekschas
0
300

Other Decks in Science

See All in Science
高校生就活へのDA導入の提案
Avatar for Shunya Noda shunyanoda
1
6.2k
俺たちは本当に分かり合えるのか？ ～ PdMとスクラムチームの “ずれ” を科学する
Avatar for Takeo Imai bonotake
2
1.9k
コンピュータビジョンによるロボットの視覚と判断：宇宙空間での適応と課題
Avatar for Hironobu Fujiyoshi hf149
1
550
データマイニング - ウェブとグラフ
Avatar for Y. Yamamoto trycycle
PRO
0
250
凸最適化からDC最適化まで
Avatar for ざきまつ santana_hammer
1
370
PPIのみを用いたAIによる薬剤–遺伝子–疾患 相互作用の同定
Avatar for Y-h. Taguchi tagtag
PRO
0
180
イロレーティングを活用した関東大学サッカーの定量的実力評価 / A quantitative performance evaluation of Kanto University Football Association using Elo rating
Avatar for konakalab konakalab
0
210
Kaggle: NeurIPS - Open Polymer Prediction 2025 コンペ 反省会
Avatar for calpis10000 calpis10000
0
410
My Little Monster
Avatar for Juzi juzishuu
0
610
データベース09: 実体関連モデル上の一貫性制約
Avatar for Y. Yamamoto trycycle
PRO
0
1.1k
2025-05-31-pycon_italia
Avatar for Sofie Van Landeghem sofievl
0
150
KH Coderチュートリアル（スライド版）
Avatar for HIGUCHI Koichi koichih
1
59k

Featured

See All Featured
Why Your Marketing Sucks and What You Can Do About It - Sophie Logan
Avatar for Sophie Logan marketingsoph
0
99
Mind Mapping
Avatar for Hélio Medeiros helmedeiros
PRO
1
110
Avoiding the “Bad Training, Faster” Trap in the Age of AI
Avatar for Mike Taylor tmiket
0
96
Connecting the Dots Between Site Speed, User Experience & Your Business [WebExpo 2025]
Avatar for Tammy Everts tammyeverts
11
850
ピンチをチャンスに：未来をつくるプロダクトロードマップ #pmconf2020
Avatar for Aki / @LoveIdahoBurger aki_iinuma
128
55k
WENDY [Excerpt]
Avatar for Tessa Abrams tessaabrams
9
36k
How To Speak Unicorn (iThemes Webinar)
Avatar for Michelle Schulp Hunt marktimemedia
1
400
Un-Boring Meetings
Avatar for Sebastian Deterding codingconduct
0
220
Winning Ecommerce Organic Search in an AI Era - #searchnstuff2025
Avatar for Aleyda Solis aleyda
1
1.9k
The Organizational Zoo: Understanding Human Behavior Agility Through Metaphoric Constructive Conversations (based on the works of Arthur Shelley, Ph.D)
Avatar for Dr. Kim W Petersen kimpetersen
PRO
0
260
Embracing the Ebb and Flow
Avatar for Simon Collison colly
88
5k
Optimising Largest Contentful Paint
Avatar for Harry Roberts csswizardry
37
3.6k

Transcript

  1. Feature-Centric Visual Exploration of Genome Interaction Maps Fritz Lekschas, PhD

    candidate
 Harvard University Benjamin Bach, Peter Kerpedjiev, Michael Behrisch, Nils Gehlenborg, and Hanspeter Pfister July 9th, 2018 ISMB 2018

  2. Cell Nucleus Contact Sequencing Heatmap 3D GENOME

  3. Gene regulation: Enhancer-promoter Structural variation: Break points Cell dynamics: Differentiation

    Cell cycle WHY CARE?

  4. 3 million × 3 million

  5. PATTERNS

  6. CHALLENGES • Size of the heatmap • Many called features

    • No ground truth GOALS • Quality control • Pattern discovery • Pattern correlation CHALLENGES
  7. None
  8. None
  9. None
  10. None
  11. None

  12. Efficiency Show all insets
 Close to origin Minimize occlusion Show

    all insets

  13. Efficiency Show all insets
 Close to origin Minimize occlusion Close

    to origin

  14. Efficiency Show all insets
 Close to origin Minimize occlusion Minimize

    occlusion
  15. None

  16. Performance comparison in pattern search on images and genome interaction

    maps User study: 18 participants and 6 domain experts Techniques: Results: faster pattern search
 more accurate pattern comparison
 easy-to-learn & easy-to-use EVALUATION

  17. CONCLUSION Explore local features in spatial context Faster pattern search

    Improved navigation

  18. Thank You! MORE INFORMATION scalable-insets.lekschas.de SOURCE CODE github.com/flekschas/higlass-scalable-insets CONTACT [email protected]

    @flekschas lekschas.de POSTER: B-765