HiPiler Visual Exploration of Large Genome Interaction Matrices with Interactive Small Multiples Fritz Lekschas, Benjamin Bach, Peter Kerpedjiev, Nils Gehlenborg, and Hanspeter Pfister
Structure of the Genome Acknowledgements: N. Abdennur, B. Alver, H. Belaghzal, A. van den Berg, J. Dekker, G. Fudenberg, J. Gibcus, A. Goloborodko, D. Gorkin, M. Imakaev, Y. Liu, L. Mirny, J. Nübler, P. Park, H. Strobelt, and S. Wang.
• How do specific pattern or average pattern look? • How variant and noisy are detected pattern? • Are there subgroups among the pattern? • How are patterns related to other data attributes? • What does the patterns neighborhood look like?
User study with 5 domain experts: Evaluating usability and usefulness Snippet approach is useful: Average / variance assessment and parameter estimation Context matters: Coordination between the snippets and matrix is highly appreciated HiPiler is easy-to-use and useful: Domain experts ask for local installations Limitations: Fixed matrix ordering and fixed aspect ratio of snippets EVALUATION