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Technology Trend Analysis of R&D Strategy on iPS Cells

hayataka
September 21, 2017

Technology Trend Analysis of R&D Strategy on iPS Cells

2017年9月、ロンドンで下記のイベントを主催しました。

Predictive Analytics in R&D & IP Strategy Development
https://www.eventbrite.co.uk/e/predictive-analytics-in-rd-ip-strategy-development-tickets-37425899874#

私の講演では、VALUENEXという会社紹介と、技術情報活用の重要性について話しました。特許、論文、研究助成といった技術情報は、経営・事業・R&D・知財戦略において重要な情報源の1つです。これらの情報源の特徴を整理しつつ、幹細胞・iPS細胞研究の俯瞰解析を事例に、情報源の違いよる得られる知見の違いを紹介しました。目的に応じて情報源を選択すること、これらのデータを融合させた分析の可能性について述べています。

hayataka

September 21, 2017
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  1. Technology Trend Analysis of R&D Strategy on IPS Cells:
    CASE STUDY ANALYSING TREND DIFFERENCES BASED ON
    PATENTS, ACCADEMIC PAPERS, OR NIH GRANT INFORMATION
    Takayoshi Hayashi
    LEAD ANALYST
    VALUENEX Seminar @
    21 September, 2017

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  2. Takayoshi Hayashi
    VALUENEX Japan Inc.
    Lead Analyst
    Self-introduction
    n Academic background
    Mar. 2013 Waseda University
    MS. Eng, Electrical and Electronics Engineering
    n Career
    Apr. 2013 Nippon Telegraph and Telephone
    Researcher on smart grid
    Jan. 2015 Recruit
    Data analyst on web service
    Apr. 2016 VALUENEX
    Lead analyst on R&D strategy
    n Specializations
    • Electric power engineering (Smart grid, renewable energy)
    • Machine learning / data science
    n Articles / International Conferences
    • Hayashi T, Wakao S. “Battery design optimization according to
    reversal PV power flow quantity from a distributing substation
    bank” Proceedings of 21st international Photovoltaic Science and
    Engineering Conference (2011)
    • Hayashi T, Wakao S. “Multi-objective design of battery operation
    in a photovoltaic system by means of PV output and load power
    forecasts” Proceedings of 27th European PV Solar Energy
    Conference and Exhibition (2012)
    • Hayashi T, Matsuyuki T, Wakao S, Inamori J, and Babasaki T.
    “Charge and Discharge Control of Electric Vehicle in PV System
    with PV Output and Load Power Forecast Information”
    Proceedings of 28th European Photovoltaic Solar Energy
    Conference and Exhibition (2013)
    • Hayashi T, Shimoo T, Wakao S. “Error Effect of PV Output and
    Load Power Forecast on Operation Design of PV System with
    Storage Battery” IEEJ Transactions on Power and Energy (2013)
    • Hayashi T, Shimoo T, Wakao S.” Error Effect of PV Output and
    Load Power Forecast on Operation Design of PV System with
    Storage Battery” Electrical Engineering in Japan (2014)
    • Hayashi T. “Research and Development Trend Analysis of
    Wellbeing AI Using Panoramic View Analytics” AAAI 2017 Spring
    Symposium (2017)
    VALUENEX ©2017 intellectual innovator 1

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  3. What is VALUENEX?
    We are a data analytics company focusing on strategy development and decision guidance, performing 100+
    consultation projects per year to leading companies and public institutions, and licensing our analytics platform.
    VALUENEX ©2017 intellectual innovator 2

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  4. BIG DATA CLUSTERING VISUALISATION ANALYTICS
    What is Panoramic View Analytics?
    Proven scientific methods that allow the user to “see and understand” the entirety of large amounts of data rather
    than “search and reading” of individual pieces of data.
    3
    Clustering docs by calculating
    similarities among them
    Visualization of the similarity
    among docs
    Original indicators for mining
    and insight
    Patents / Research Papers / SNS
    News / Annual Reports, etc.
    VALUENEX ©2017 intellectual innovator

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  5. What is Panoramic View Analytics?
    You can get insight for strategy-making by analyzing output (distance, density, white space, distribution, etc.) of the
    radar chart.
    4
    The size of each cluster is
    proportional to the number of
    documents in it.
    The distance between clusters
    indicates the similarities between
    them.
    The axes have no particular meaning.
    Each circle is called a cluster.
    They contain similar documents.
    HIGH DENSITY
    LOW DENSITY
    TREND LINE
    VALUENEX ©2017 intellectual innovator
    CENTER OF GRAVITY

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  6. Our Services / Today’s Presentations
    5
    IP section
    R/D section
    Corporate planning
    section
    INDUSTRIAL
    COMPANY
    FINANCIAL
    ORGANIZATION
    Corporate sales/ CA
    M&A
    Start-up investment
    OTHERS
    (CONSULTING)
    Consulting (strategy)
    Consulting(M&A)
    New business development
    strategy
    R/D strategy
    Alliance strategy
    Technology due diligence
    IP portfolio strategy
    Open innovation strategy
    Proposal with additional value
    BUSINESS / JOB CATEGORY APPLICATION
    VALUENEX ©2017 intellectual innovator
    Takayoshi
    Hayashi
    Dr. Nakamura
    Dr. Liu

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  7. IMPORTANCE OF
    TECHNOLOGY INFORMATION ANALYSIS
    IN T R OD U C T ION

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  8. Importance of Technology Information Analysis
    IP / Technology information analysis can support management / business / R&D / IP strategies.
    7
    Ref: http://www.jpo.go.jp/shiryou/toushin/nenji/nenpou2004_pdf/honbun/3-1-2.pdf
    Business
    Strategy
    R&D Strategy
    Intellectual
    Property Strategy
    • Utilizing IP/technology information for
    making business strategies, such as new
    business development, business
    collaboration, etc.
    • Acquiring rights from view points of attack,
    defense, and prevention based on
    business strategy.
    • Utilizing IP/technology information for
    analyzing one’s technology capabilities and
    deciding R&D focus.
    • Utilizing IP/technology information for
    selecting partners for R&D collaboration.
    • Acquiring rights strategically for
    standardization of one’s technology.
    • Preliminary survey
    • Prior art search (R&D, filing, application for examination, etc.)
    • Other company trend survey (Making patent map etc.)
    • Acquiring rights (filing patent, trade secret)
    • Protection and utilization of rights (own monopoly, license, measures against counterfeit
    products and management of technology / know-how in foreign markets)
    IP / Technology
    Information Analysis
    Management
    Strategy
    VALUENEX ©2017 intellectual innovator
    Figure: Relationship among 3 types of
    management strategies

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  9. Importance of Technology Information Analysis
    There are various technology information analyses according R&D and IP cycles.
    8
    Basic / Application
    Research
    Development
    Design
    Production
    Commercialization
    Marketing
    Sales
    Technology trend analysis
    Collection search
    Prior art search (Pre-filing search)
    Invalidity search
    Clearance search, FTO
    Technology
    assessment
    R&D cycle
    Technology
    Information
    Research /
    Analysis
    Figure: Relationship among IP, R&D and technology information research / analysis
    Ref: Atsushi Nozaki: Patent Research and Search Technique (2015) [Japanese]
    Creating inventions
    Making IP strategy
    Protecting inventions
    Filing, Rights, Patent portfolio
    Utilizing inventions
    One’s usage, Licensing
    IP cycle
    VALUENEX ©2017 intellectual innovator

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  10. How do you perform technology information
    analyses?
    9
    Simply reading?
    VARIOUS TYPES OF
    INFORMATION
    • Patents
    • Academic papers
    • Research grants
    • Cloud funding
    • Start-up information, etc.
    VALUENEX ©2017 intellectual innovator
    HUGE VOLUMES
    • Doc number: thousands ~ millions
    • Length: long…

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  11. Volume of Technology Information on
    “Stem and iPS cells”
    • Volume: Technology information volume on stem / iPS cells is enormous.
    • Time: It takes an excessive amount of time to get insight by simply reading.
    • Difficulty: It is difficult to classify by keywords, inventors, etc. because there are various research themes.
    • Risk: If you set keywords for classification in advance, you may miss new research opportunities.
    10
    * The number of documents including “stem cell” or “ips cell”
    Patents Academic papers Research grants
    Volume
    10,000 (Title, Abstract, Claim)
    50,000 (Full text)
    245,000 60,000
    Source
    US application
    (DB: PatentSquare)
    PubMed NIH
    Table: Volume of patents, academic articles, and research grants on Stem / iPS cells*
    VALUENEX ©2017 intellectual innovator

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  12. Technology Information Features
    There are many differences among features of patents, academic papers, and research grants.
    11
    Patents Academic papers Research grants
    Overview
    Patent is for protecting one’s R&D
    achievements and manufacturing / selling
    products.
    Academic article is for informing others of
    one’s R&D achievements. Thus, it is
    sometimes not with the intention to sell
    achievements as products.
    Research grant is for gathering R&D from
    organizations. It is published by the funding
    organization unlike patent and academic
    research.
    Player Company > University, Research institution University, Research institution > Company University, Research institution > Company
    Sentence characteristics
    ˚: Patent should be written concretely
    because the other engineers must be able to
    implement it. However, patent has the legal
    and strategic perspectives. Thus, it is
    sometimes not easy to read.
    ˓: Academic article is written for easy reading
    because it is intended for the general public.
    ˓: Research grant is written for easy reading
    because it is intended for the general public.
    Bibliographic
    information
    Format ˓: Unified globally (INID) ˚: Depend on the journal ˚: Depend on the funding organization
    Classification ˓: Unified globally (IPC) ˚: Depend on the journal ˚: Depend on the funding organization
    Citation
    ˚: Citation by applicant includes arbitrariness.
    In the case of citation by examiner,
    arbitrariness is small.
    ˓: Arbitrariness is less than patent. -
    Others Number, Inventor, Assignee, Date, etc. Author, Organization, Impact Factor, etc. Researcher, Organization, Earned amount, etc.
    Availability
    ˓: You can get full text easily and free or with
    minimal cost because patent is open data, and
    there are many database options.
    ˚: There are many free / paid database
    options. You can get “Title” and “Abstract”
    easily for free or with minimal cost. Full text
    might be expensive. In the case of publication
    on web, data processing might be necessary.
    ˚: Funding organization may provide search
    database. However, it depends on the funding
    organization. You can get research overviews
    and achievements (academic articles, patents,
    technical reports, etc.)
    VALUENEX ©2017 intellectual innovator

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  13. TECHNOLOGY TREND ANALYSIS
    ON STEM/iPS CELLS
    C A S E S T U D Y

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  14. Technology Development Overview: Patents
    There are various R&D areas from stem cells to medicine, disease (cancer) and body repair.
    13
    Medicine /
    Compound
    Cancer
    Mesenchymal
    stem cell
    Hair follicle
    stem cell
    Fat
    Hydrogel
    Figure: Radar chart of patents
    Extracellular
    Matrix
    Gene
    Nuclease
    Hematopoietic
    cell
    Reprogramming
    of iPS cell
    Oocyte
    microRNA
    Tooth
    Recombination
    Human ES cell
    NSC
    Placenta
    Disease
    (Cancer)
    Body Repair
    etc.
    Control of
    Stem Cells
    Research on Cells
    Figure: Technology area position
    Medicine /
    Compound
    Plerosis using
    scaffold
    VALUENEX ©2017 intellectual innovator

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  15. Technology Development Overview:
    Academic Papers
    • Overall structure is similar to patents.
    • Compared to patents, cancer stem cell and HSC (hematopoietic stem cell) transplantation areas are
    active.
    14
    Neural Stem Cell
    Heart
    Cancer stem cell
    Musculoskeletal
    Treatment
    Bone regeneration /
    Reconstruction
    Spermatogonial
    stem cell
    Mesenchymal stem cell
    (Transplant)
    Hematopoietic stem cell
    (Mouse experiment)
    Cornea
    SCF
    Interleukin
    Hematopoietic Stem Cell Transplantation / Graft Versus Host Disease (GVHD)
    Body Repair
    Cancer
    Stem Cells
    Control of
    Stem Cells
    Research on Cells
    Mesenchymal stem cell
    (Culture)
    Transplantation
    Therapy (HSC:
    Hematopoietic
    Stem Cell)
    Figure: Radar chart of academic articles Figure: Technology area position
    Reprogramming
    VALUENEX ©2017 intellectual innovator

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  16. Technology Development Overview:
    Research Grants
    • Overall structure is similar to patents and academic papers.
    • There are various areas on diseases and body repair.
    15
    Fanconi Anemia
    Acute Myelogenous
    Leukemia
    Chronic Myelogenous
    Leukemia
    GVHD
    HIV
    β-globin
    Liver cell
    Education Program
    (Noise)
    Blood vessel
    Heart
    Muscle Regeneration
    Tendon care
    Cartilage
    Repair
    Myeloid
    Stem Cell
    HSC
    Liver
    Disease
    Diabetes
    Breast Cancer
    Glial Tumor
    Intestinal Stem Cell
    Lung
    Generative Cell (Male)
    Scalp Hair, Skin
    Cornea
    Retina
    Neuron cell
    Alzheimer's disease
    Epigenetics
    Disease
    (Leukemia, HIV,
    Diabetes etc.)
    Body Repair
    (Bone, Heart, Cartilage,
    Tendon, Neuron cell,
    Retina etc.)
    Control of
    Stem Cells
    Research on Cells
    Figure: Radar chart of research grants Figure: Technology area position
    Reprogramming
    VALUENEX ©2017 intellectual innovator

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  17. Technology Development Overview: Summary
    • In particular, there is a big difference regarding disease and treatment among the information sources
    (Research grants > Academic articles > Patents). These areas were studied in the past, but the effectiveness
    was not confirmed. Or, they might be waiting for, or expecting, new fields to emerge.
    • In the case of patents, there are several compounds and medicines (mainly used for culturing stem cells).
    16
    Cell Disease / Treatment Others
    Patents
    Oocyte, Human ES cell, NSC,
    Mesenchymal stem cell, Hair follicle
    stem cell, Placenta, Hematopoietic cell,
    Adipocyte
    Cancer, Tooth, Plerosis using scaffold
    Reprogramming, Gene,
    Compounds / Medicine
    Academic
    papers
    Hematopoietic cell (Transplant,
    Culture), Hematopoietic stem cell,
    Neural stem cell, Cancer stem cell
    Bone regeneration / reconstruction,
    Musculoskeletal treatment, Cornea,
    Hematopoietic stem cell transplantation
    (GVHD)
    Reprogramming, Interleukin, SCF,
    etc.
    Research
    Grants
    Liver cell, HSC, Generative cell,
    Intestinal stem cell,
    Myeloid stem cell, Neuron cell
    Fanconi anemia, (Acute, Chronic)
    myelogenous leukemia, Liver disease,
    Diabetes, Glial tumor, Scalp hair / skin,
    Retina, Cornea, Alzheimer‘s disease,
    Cartilage repair, Tendon care, Muscle
    regeneration, Heart, Blood vessel, HIV,
    GVHD
    Reprogramming, Epigenetics, etc.
    Table: Comparison among insights from information sources
    VALUENEX ©2017 intellectual innovator

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  18. Time Series Evolution Analysis
    • Patents: (1) “Recombination” is active. (2) “Reprogramming of iPS cell” and “Extracellular Matrix” are active.
    • Academic papers: (1) “Reprogramming” and “HSC (Hematopoietic stem cell) transplantation” are active. (2) R&D spread to
    many areas close to “Cancer stem cell”
    • Research grants: (1) “GVHD with HSC (Hematopoietic stem cell) transplantation” and “Diabetes” are active. (2) R&D spread
    around areas.
    17
    (1) Past
    (2001 – 2004)
    PATENTS ACADEMIC PAPERS RESEARCH GRANTS
    Figure: Time series change
    Recombination
    (HSC) Hematopoietic Stem
    Cell Transplantation
    Reprogramming GVHD With Hematopoietic
    Stem Cell Transplantation
    Diabetes
    (2) Recent
    (2013 – 2017)
    Extracellular
    Matrix
    Reprogramming
    of iPS Cell
    R&D Areas Spread R&D Areas Spread
    Cancer Stem
    Cell
    VALUENEX ©2017 intellectual innovator

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  19. Publisher Analysis
    • There is a high number of universities. (Companies usually make up most of the patent ranking in other fields.)
    • Californian Universities are top in class of every information source.
    • Almost all publishers are North American organizations, but Kyoto University (Japan) appears in Patent and
    Academic Papers, as well as A*Star (Singapore) in Patents.
    18
    Figure: Main publishers of each information source
    0 20 40 60 80 100 120 140
    Univ of California
    IMMUNOMEDICS, INC.
    THE GENERAL HOSPITAL CORP.
    AGENCY FOR SCI., TECH. &
    RES (A-STAR)
    KYOTO UNIV.
    JOHNS HOPKINS UNIV.
    MIT
    ANTHROGENESIS CORP.
    UNIVERSITY OF MICHIGAN
    Univ. of Southern California
    0 200 400 600 800 1,000
    STANFORD Univ.
    BASIC SCIENCES
    JOHNS HOPKINS Univ.
    Univ. OF PENNSYLVANIA
    Univ. OF WASHINGTON
    FRED HUTCHINSON CANCER
    RESEARCH CENTER
    MASSACHUSETTS GENERAL
    HOSPITAL
    Univ. OF CALIFORNIA LOS
    ANGELES
    Univ. OF CALIFORNIA, SAN
    FRANCISCO
    Univ. OF MICHIGAN
    0 50 100 150 200
    Univ. of California
    Stanford Univ.
    Kyoto Univ.
    Univ. of Washington
    Univ. of Toronto
    Univ. of Cambridge
    Univ. of Michigan
    Baylor College of Medicine
    Harvard Medical School
    Massachusetts General
    Hospital
    ■ - 2012
    ■ 2013 -
    ■ - 2012
    ■ 2013 -
    ■ - 2012
    ■ 2013 -
    PATENTS ACADEMIC PAPERS RESEARCH GRANTS
    VALUENEX ©2017 intellectual innovator

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  20. Publisher Analysis
    You can get insight from the differences among publishers by combining various technology information sources.
    19
    Figure: R&D fields of Kyoto Univ. and Univ. of California
    UNIV. OF CALIFORNIA KYOTO UNIV.
    PATENTS ACADEMIC PAPERS RESEARCH GRANTS
    Heart
    Neural Stem Cell
    Spermatogonial
    Stem Cell
    Reprogramming
    Spermatogonial
    Stem Cell
    Heart
    Reprogramming
    HSC (Hematopoietic Stem Cell)
    Transplantation / GVHD
    Musculoskeletal
    Treatment
    They focus on reprogramming of iPS
    cell. Are these fundamental patents?
    HIV
    Education
    Program (Noise)
    Alzheimer's
    Disease
    Reprogramming of iPS cell are few.
    However, they file patents widely.
    1
    2
    3
    4
    n Insights
    1. Kyoto Univ. has fundamental patents on
    reprograming of iPS cells?
    2. In academic articles, you can see R&D fields
    that do not appear in the patents landscape.
    3. The characteristic field of Kyoto Univ. is “HSC
    (Hematopoietic stem cell) transplantation /
    GVHD”. The Univ. of California’s is “Neural
    stem cell”.
    4. Research grants for Univ. of California are
    concentrated in HIV and Alzheimer’s disease
    fields.
    VALUENEX ©2017 intellectual innovator

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  21. Growing Area Analysis
    • Red squares show growing areas. These are extracted by counting documents in each mesh of the radar.
    • The growing areas are different among information sources as shown below.
    20
    Application of
    Adipose Stem Cell
    Extracellular
    Matrix
    Scaffold (Manufacturing Method
    of Electro Spinning Process)
    Cancer Treatment using
    Chimeric Antigen Receptor
    CRISPR CAS9
    Effect of Inorganic
    Substances to Cells
    (cancer etc.)
    Relationship between
    Autophagy, Metabolism,
    and Cancer
    Application of
    Hematopoietic Stem
    Cells
    Clarification
    and Repair of
    Heart Disease
    Utilization and
    Control of
    Human ES Cell
    Reproduction
    Signal Transmission
    in Retina
    Genea Biocells
    (relationship with gene)
    Leukemia Inhibitory
    Factor (LIF)
    Reprogramming
    of iPS cell
    Synthesis of
    Hydrogel
    Glioblastoma
    Multiforme
    Figure: Growing areas of each information source
    VALUENEX ©2017 intellectual innovator
    PATENTS ACADEMIC PAPERS RESEARCH GRANTS

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  22. Conclusion
    • Technology information is an important element for strategy development. There are huge volumes and
    various kinds, like patents, academic papers, and research grants.
    • In this presentation, we went over a macro analysis of R&D trends on “Stem / iPS cells”. The obtained insights
    are different among information sources.
    • The features of information sources vary. Therefore, you should apply them according to the individual
    analyses objectives. For example, research grants are the most basic and patents are the most practical.
    Moreover, sentence characteristics and bibliographic information, etc., are different.
    • If you want find application fields where your technology can be applied in the near future:
    Patent > Academic paper > Research grant
    • If you want find novel R&D focuses and application fields in the long term: Research grant >
    Academic paper > Patent
    • For a data fusion analysis, you can find the next R&D theme and collaborators with the flow below.
    22
    Panoramic view analytics of
    research grant information
    • Earned amount from research grant
    • Research achievements assessment
    from academic papers and patents
    of researchers (Impact Factor,
    Position and synergy analysis by
    panoramic view analytics, etc.)
    • Next R&D themes
    • Potential collaborators
    EXTRACTION OF GROWING AREAS ASSESSMENT OF EACH AREA OUTPUT
    VALUENEX ©2017 intellectual innovator

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  23. Contact US
    VALUENEX ©2017 intellectual innovator 23
    Takayoshi Hayashi
    Lead Analyst, VALUENEX Japan Inc.
    [email protected]
    Navigate the Ocean of Big Data
    Harness the power of Panoramic View Analytics

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