Vulnerable populations, like those with mental health and addiction problems, have multiple health risk behaviors. But, they typically are not prepared to take action in seeking treatment to change their risk behaviors. Understanding how to best engage this important population begins with a deeper knowledge of the dynamics of being stuck in the early stages of change. Such understanding can generate strategies to reach these individuals, recruit and retain them in treatment, and help them progress through the stages to increase their success in reducing their risks. Recent breakthroughs have generated synergistic strategies for changing multiple behaviors, while reducing demands on providers and their patients. Relating to the whole person can simultaneously reduce multiple risks while enhancing multiple domains of well-being: physical, emotional, social, and purposeful well-being. What is particularly rewarding is to help populations where the majority are suffering or struggling to progress to where the majority are thriving.