of meetings, ship the wireframes to a designer. Designer generates a pile of PSD’s. Have hapless “web designers” slice things up and make table layouts, or mild CSS if you’re lucky.
Wireframe anywhere — Illustrator, Balsalmic, etc. (Even on paper using UI Stencils.) Make friends with the grid. Use Twitter Bootstrap to create one, or make your own homegrown 960 grid stylesheet. Iterate, iterate, iterate. Git is the new layers. Plus, PSD comp @ 45MB, Code Comp @ 70k.