provides the COST Office through an EC contract BM0803: A European network of the HLA diversity for histocompatibility, clinical transplantation, epidemiology and population genetics (HLA-NET) Action Chair: Prof. Alicia Sanchez-Mazas Rapporteur: Prof. Aleksandar Dimovski Science Officer: Dr. Magdalena Radwanska Start date: 29/01/2009 End date: 28/01/2013
provides the COST Office through an EC contract 2 Scientific background (1) Researchers in clinical transplantation, epidemiology and population genetics need a fine characterization of the HLA molecular profile of human populations: (1) to control stem cell and organ donor-recipient matching, (2) to assess susceptibility or resistance in autoimmune disorders and infectious diseases, (3) to study the genetic structure of human populations and the mechanisms of molecular evolution. Epidemiology HIV Malaria Transplantation Donor Recipient Public health Basic science Population genetics HLA loci on chromosome 6
provides the COST Office through an EC contract 3 Scientific background (2) HLA data are: -highly complex: more than 1,500 alleles at some loci -heterogeneously defined at the molecular level: presence of ambiguous genotyping results. This greatly impairs their use by researchers in the 3 domains transplantation, epidemiology, and population genetics. Four main issues have to be addressed in daily practice: 1.How can a population sample for different applications be defined accurately? 2.How can data be generated in order to be comparable to those of other laboratories? 3.How can gene frequencies and other statistics with highly complex data be estimated? 4.What legal /ethical rules should be followed to harmonize with national requirements?
provides the COST Office through an EC contract 4 Objectives based on the MoU (1) HLA-NET aims to offer an innovative framework by which scientists in 3 different research fields: - bone marrow transplantation - epidemiology - population genetics put their expertise in laboratory work, clinical work, ethical issues, population genetics, biostatistics and/or computer science into contribution to elaborate consensual standards, define common procedures and share high quality data and tools.
provides the COST Office through an EC contract 5 Objectives based on the MoU (2) Through an inter-disciplinary network, the Action aims at improving the molecular characterization of the HLA genetic diversity of human populations in a standard way in order to ensure data quality and allow comparative studies.
provides the COST Office through an EC contract 6 Action/Network structure COUNTRIES: (20) AT, BE, BG, CH, DE, DK, ES, FI, FR, GR, HR, IT, LV, NL, NO, PL, PT, SI, UK + AL (NON-COST). DECLARED INTEREST (4): CY, CZ, TK, SA (NON-COST). PARTICIPANTS: 45 participants, 23 females, 7 ESR. Four main aspects of
provides the COST Office through an EC contract 7 Scientific deliverables (1) • Building a consensus in various research fields for scientific community – Final population data questionnaire – Guidelines for reporting HLA typings
provides the COST Office through an EC contract 8 Scientific deliverables (2) • Building a consensus in various research fields for scientific community – New algorithm for data analysis (split test) – New algorithms for population genetics using resampling schemes – Common scheme for databases Sample Population Frequencies Publication
provides the COST Office through an EC contract 9 Scientific deliverables (3) • Novel research ideas – High impact research papers ¾ 8 articles published in 2010 or prepared in 2010 and published in 2011, with acknowledgments to HLA-NET. ¾ 4 conferences presenting HLA-NET in 2010-2011 international immunogenetics meetings (Czech Republic, Italy, France and Greece). ¾ 3 posters & published reports. acknowledgments
provides the COST Office through an EC contract 10 Scientific deliverables (4) •Tangible impact on public health -Improvement of donor search in stem cell transplantation -Development of preliminary strategies to analyze complex HLA data from Bone Marrow Donor registries
provides the COST Office through an EC contract 11 Deliverables – Capacity building (1) • Building networks – New networks through EFI (pan-European+international) – New networks through IHIW (International)
provides the COST Office through an EC contract 12 Deliverables – Capacity building (2) • Building networks – Technology transfer (training schools) “POPULATION ANALYSES FOR HLA AND OTHER IMMUNOGENETIC SYSTEMS” ISPUP – Public Health Institute of the University of Porto. University of Porto (Portugal) 21-24 Feb, 2011 60 applications, 30 participants from 19 different countries: Albania, Belgium, Brazil, Bulgary, Czech Republic, Finland, France, Greece, Germany, India, Portugal, Russia, Serbia, Slovenia, Spain, Switzerland, The Netherlands, United Kingdom and Portugal.
provides the COST Office through an EC contract 13 COST visibility (1) Through HLA-NET website: http://hla-net.eu/ Currently, mostly internal use (wiki) of website (HLA-NET participants) Large opening (pan-European and international) since 2012 with HLA-NET main achievements (guidelines, programs, databases) Statistics 2010-2011
provides the COST Office through an EC contract 15 COST visibility (3) Through coordination with other funded research projects and their scientific deliverables FNS – funded human peopling history project Swiss COST- funded analysis of BMD registries International visibility National, European and international visibility
provides the COST Office through an EC contract 17 Future prospects Further research interests include: -The molecular evolution of HLA genes, i.e. the impact of both selective forces (e.g. pathogen-driven selection, frequency-dependent selection, ..) and the history of human populations (e.g. genetic drift, migrations, demographic expansions); -The expression of HLA genes, i.e. their regulation depending on different environments; -The « acceptable mismatch » organ transplantation program enlarged to different populations. These topics involve news relationships between population genetics, epidemiology, and transplantation, and thus new networking for standardization of HLA data typing and reporting, statistical methods and other issues.
provides the COST Office through an EC contract 18 COST rapporteur BM0803 first rapporteur: never met (no contact, no report) New rapporteur since end 2010: a) Met already once during last MC/WG meeting (March 2011) b) Excellent contact, scientific discussions c) Suggestions to improve this interaction: - through wiki - at additional meetings (e.g. core meetings)
provides the COST Office through an EC contract 19 What sort of COST would you like? and for Whom? • New possible COST activities – STT (short term training) and STL (short term lecture): ¾ single specialist travelling to train people during a short period within an institution participating to an Action, e.g. statistician or computer specialist training wet lab researchers during 3 days, etc ¾ COST grant to fund teaching (funding could also be applied to trainers in TS) ¾ target audience: students, technicians, established scientists ¾ stimulates inter‐disciplinarity – SSM (satellite scientific meetings): ¾ before of after MC/WG meeting, additional day dedicated to scientific presentations only, with possible invited speakers ¾ target audience: all COST Action participants ¾ stimulates science