HLA-NET Riga 2013

Transcript

1. ESF provides the COST Office through a European Commission contract COST is supported by the EU Framework Programme Annual Progress Conference Action BM0803 A European network of the HLA diversity for histocompatibility, clinical transplantation, epidemiology and population genetics 3-4 June 2013, Riga Action Chair: Prof. Alicia Sanchez-Mazas Rapporteur: Prof. Aleksandar Dimovski Science Officer: Dr. Ilias Papadopoulos Start date: 29/01/2009 / End date: 28/01/2013 COST Domain - Biomedicine and Molecular Biosciences (BMBS)
2. Action Network Structure 22 participating countries, 47 members with 24 females (51%) and 7 ESR (15%) AL, AT, BE, BG, CH, CY, DE, DK, EE, EL, FI, FR, HR, HU, IT, LV, NL, NO, PL, PT, SI, UK Cyprus 2
3. Scientific scope (1): Work efficiently at the crossroads of several scientific areas related to HLA molecular diversity Peptide APC Lymphocyte T Number of HLA alleles (January 2013) 158 36 179 49 1,196 2,798 1,672 2,132 0 500 1,000 1,500 2,000 2,500 3,000 DPB1 DPA1 DQB1 DQA1 DRB1 B C A Transplantation Donor Recipient Population genetics Disease-associations HIV Malaria 3
4. 4 Scientific scope (2): Provide standard guidelines and tools to analyse HLA genes in human populations at the European level
5. Scientific scope (3): Generate significant results to catalyze European research in immunogenetics, population genetics and transplantation 5 HLA molecular variation among populations HLA matching for transplantation
6. Scientific outputs (1): Standard questionnaire, guidelines and computer tools online 6 Guidelines for reporting HLA typings Questionnaire for population characterisation Computer programs for data analysis
7. 7 Scientific outputs (2): Integrated HLA-NET platform with long-term access http://hla-net.eu/ http://en.wikipedia.org/wiki/HLA-NET Databases of HLA-typed populations Computer Tools Documents Wikipedia page of HLA-NET
8. Scientific outputs (3): Detailed reference map of HLA variation in Europe Maps of 25 to 45 pan-European populations (3’338 to 9’044 individuals) Sanchez-Mazas et al. (in prep.) DRB1*07:01 DRB1*15:01 DQB1*02:01 DQA1*02:01 DRB1*11:01 DRB1*11:04 B*18:01 A*24:02 DQA1*05:01 DQB1*03:01 8 Final publication in preparation
9. 9 Scientific outputs (4): Publications & conferences 2012 2011 HLA-NET publications with acknowledgments:  16 articles  8 abstracts  5 reports  21 talks 2013
10. 10 Capacity building (1): High-level interdisciplinary education HLA-NET educational events  18 STSM  1 Training school  1 Educational workshop Training school – Porto 2011 Porto Liverpool Helsinki Oslo London Athens Nicosia Budapest Sofia Tirana Montpellier Marseilles Geneva Ulm Tübingen Milano Brussels Kongens Lyngby Leiden STSM Educational workshop – Vienna 2012
11. 11 Capacity building (2): European BMD registry Consortium 01 - Bas-Saint-Laurent (N=89/86/582) 11- Gaspésie- Îles-de-la-Madeleine (N=10/10/137) 12 - Chaudière-Appalaches (N=377/381/844) 10 - Nord-du-Québec (N=4/4/18) 09 - Côte-Nord (N=35/36/154) 08 - Abitibi- Témiscamingue (N=88/86/126) 02 - Saguenay-Lac- Saint-Jean (N=74/82/674) 04 - Mauricie (N=80/76/307) 07 - Outaouais (N=97/101/401) 03 - Capitale-Nationale (N=670/677/1348) 05 - Estrie (N=104/103/318) 15 - Laurentides (N=161/168/416) 16 - Montérégie (N=727/742/1541) 17 - Centre-du- Québec (N=111/109/650) 14 - Lanaudière (N=543/550/715) 13 - Laval & 06 - Montréal (N=279/279/496 & 2081/2107/3100) Pays de la Loire (n=108) Alsace and Lorraine (n=251) Centre (n=105) Bourgogne (n=223) Île-de-France (n=529) Champagne-Ardenne and Picardie (n=148) Nord-Pas-de-Calais(n=175) Basse-Normandie, Bretagne and Haute-Normandie(n=209) Aquitaine, Limousin and Poitou-Charentes (n=145) Franche-Comté (n=118) Auvergne (n=131) Provence-Alpes-Côte d'Azur (n=244) Rhône-Alpes (n=5335) 01 Ain (n=268) 07 Ardèche (n=338) 26 Drôme (n=567) 38 Isère (n=1310) 42 Loire (n=224) 69 Rhône (n=1459) 73 Savoie (n=625) 74 Haute-Savoie (n=544) Languedoc-Roussillon and Midi-Pyrénées (n=147) Current EFI Newsletter  Analyses of European-related BMD registry datat 17th EFI meeting award, Maastricht 2013
12. 12 Capacity building (3): HLA-NET participation to European FP7 research programme Current EFI Newsletter EUROSTAM 2012-2015 (2.6 MЄ) to improve organ transplantation in Europe
13. 13 Capacity building (4): Potential to set up new projects by integrating new technologies Next generation sequencing Current EFI Newsletter
14. 14 Capacity building (5): HLA-NET integration to the EFI Society Maastricht (NL) EFI Annual meeting May 2013, 800 attendees Subgroup of the Scientific Committee
15. 15 Capacity building (6): Development of extended interdisciplinary networks Population genetics meeting – Geneva 2013 Special volume to be published end 2013
16. 16 Capacity building (7): HLA-NET participation to International HLA workshops Liverpool (UK) May 2012 San Francisco (USA) Automn 2017