HLA-NET Zagreb 2012

Transcript

1. ESF provides the COST Office through a European Commission contract COST is supported by the EU Framework Programme Annual Progress Conference Action BM0803 A European network of the HLA diversity for histocompatibility, clinical transplantation, epidemiology and population genetics 29-30 May 2012, Zagreb Action Chair: Prof. Alicia Sanchez-Mazas Rapporteur: Prof. Aleksandar Dimovski Science Officer: Dr. Magdalena Radwanska Start date: 29/01/2009 / End date: 28/01/2013 COST Domain - Biomedicine and Molecular Biosciences (BMBS)
2. Scientific scope (1) 2 Researchers in clinical transplantation, epidemiology and population genetics need a fine characterization of the HLA molecular profile of human populations: (1) to control stem cell and organ donor-recipient matching, (2) to assess susceptibility or resistance in autoimmune disorders and infectious diseases, (3) to study the genetic structure of human populations and the mechanisms of molecular evolution. Epidemiology HIV Malaria Transplantation Donor Recipient Public health Basic science Population genetics HLA loci on chromosome 6 HLA-NET aims to Offer an innovative framework by which scientists in bone marrow transplantation, epidemiology and population genetics share their expertise in laboratory work, clinical work, ethical issues, population genetics, biostatistics and computer science.
3. 3 Through an inter-disciplinary network, the Action aims at improving the molecular characterization of the HLA genetic diversity of human populations in a standard way in order to ensure data quality and allow comparative studies. Scientific scope (2) HLA-NET aims to Elaborate consensual standards and define common procedures in immunogenetics to be used in daily practice and fundamental research.  Share high quality data and computer tools to analyze the HLA genetic diversity of human populations.
4. 0% 5% 10% 15% 20% 25% 0% 5% 10% 15% 20% 25% Scientific scope (3) 0% 5% 10% 15% 20% 25% 30% 35% Locus HLA-A North Europe & Quebecers Central Europe Southeast Europe Colors = geographic areas Locus HLA-B North Europe & Quebecers Central Europe Southeast Europe HLA-NET aims to Construct a detailed HLA map of Europe and pan-European regions. 4
5. Action network structure 5 New Action MC members: 2011: Bulgaria, Cyprus 2012: Hungary 22 countries = 21 COST + 1 non-COST (AL) Participating countries AL, AT, BE, BG, CH, CY, DE, DK, EE, EL, FI, FR, HR, HU, IT, LV, NL, NO, PL, PT, SI, UK
6. Scientific outputs related to networking (1) 6 Questionnaire and guidelines online WG1 & WG2 & WG3 & WG4
7. Scientific outputs related to networking (1) 7 Questionnaire and guidelines online WG1 & WG2 & WG3 & WG4 7 Common paper published by 34 authors (Action members), currently online in early view, Open access, Acknowledgments Publication not possible without COST
8. Scientific outputs related to networking (2) 8 Description of the molecular variation outside PBR coding exons Poster at the joint 16th IHIW-26th EIHC- 23th BSHIC, Liverpool May-June 2012 WG2 DRB1*14:01:01G exon 2 exon 3 112
9. Scientific outputs related to networking (3) 9 Database designed, new computer tools available and bioinformatic pipeline running WG1 & WG3 In preparation AN INTEGRATED DATABASE SCHEMA TO REPRESENT GENETIC, GEOGRAPHICAL AND LINGUISTIC DIVERSITY FOR THE STUDY OF HUMAN POPULATIONS. Vangenot C, Galarza-Gonzalez F, Sanchez-Mazas A, Middleton D, Nunes JM Poster at the joint 16th IHIW-26th EIHC- 23th BSHIC, Liverpool May-June 2012 Common paper in preparation by 5 Action members, Acknowledgments
10. 10 Scientific outputs related to networking (4) HLA-NET platform
11. Strategies to analyze Bone Marrow Donor (BMD) registries Tangible impact on public health Scientific outputs related to networking (5) 11 Under review (PLoS ONE) AN THE HETEROGENEOUS HLA GENETIC MAKEUP OF THE SWISS POPULATION Buhler S, Nunes JM, Nicoloso G, Tiercy JM and Sanchez-Mazas A Common paper in preparation by 4 Action members, Acknowledgments Poster at the joint 16th IHIW-26th EIHC- 23th BSHIC, Liverpool May-June 2012 11
12. Capacity building related to networking (1) 12 Derek Middleton, MC member (UK) Allele*Frequencies coordinator
13. Capacity building related to networking (2) 13 Gottfried Fischer, MC member (AU) EFI President 2012-2014 Dissemination through EFI Newsletter
14. Capacity building related to networking (3) 14 Frans Claas (NL), Derek Middleton (UK), Jean-Marie Tiercy (CH), Steven Marsh (UK), Alicia Sanchez-Mazas (CH), Soren Buus (DK), Carlheiz Muller (DE) MC members IHIW COUNCILLORS
15. Capacity building related to networking (4) 15 Frans Claas, MC member (NL) « EUROSTAM » coordinator FP7 – Health 2012-2015 ** Funded ** Other COST partners: Alicia Sanchez-Mazas (CH) Derek Middleton (UK) Jaime Martorell (SP)
16. 16  Research papers • 10 peer-reviewed articles published in 2011 or prepared in 2011 and published in 2012, with acknowledgments to HLA-NET.  Meetings/conferences: • EFI REGION 8 Histocompatibility & Immunogenetics Laboratories Meeting (Athens, March 2011) •EFI meeting (Prague, May 2011) • Discussion meeting on Human evolution, migration and history revealed by genetics, immunity and infection, Royal Society (London, June 2011) •15èmes Journées Educationnelles de l'EFI (Tours, Sept 2011) •«HLA-NET open meeting» at the Joint 16th International HLA and Immunogenetics Conference/26th European Immunogenetics and Histocompatibility Conference/23rd British Society of Histocompatibilty and Immunogenetics Conference (Liverpool May-June 2012) Dissemination Dissemination through the Geneva University Euresearch Newsletter, Feb. 2012
17. Action BM0803 STSM: budget and list Year Name OUT  IN ------------------------------------------------------------------------------ 2009 5.8% of scient. budget Galarza Faviel UK  CH  Riccio Eugenia CH  IT  2010 2% of scient. budget Catanzaro Daniele BE  CH  2011 4.7% of scient. budget Carvalho Cláudia PT  UK  Riccio Eugenia CH  FR  2012 13.2% of scient. budget Buhler Stéphane CH  AU Cuénod Mélanie CH  NO  Gonzalez Faviel UK  DK Kitsiou Vera GR  NL  Kouniaki Diamanto GR  DE  Lukanov Tzvetelin BG  CH  Nokelainen Johanna FI  DE  Nunes José Manuel CH  UK  Pasholi Jonila AL  IT  Sanchez-Mazas Alicia CH  UK  Shyti Erkena AL  IT  Stylianou Galatia CY  CH  Vlachopoulou Efthymia FI  DE  17
18. Action BM0803 website statistics 18 Visits Sites 2010 2011 2012 Pages Hits 2010 2011 2012
19. Action BM0803 rapporteur BM0803 rapporteur (since end 2010) : Aleksandar Dimovski ----------------------------------------------------------------------------------------- a) Met in MC/WG meeting (March 2011) b) A few e-mail contacts c) Excellent contact, scientific discussions d) Suggestions to improve this interaction: - through wiki - at additional meetings (e.g. core meetings) e) Rapporteur important to follow the Action, point missing aspects, stimulate participation, report on the Action 19