Threads

My slides from iAnnotate 2013, describing how you might take the Encode Threads idea, and make a more general version.

Transcript

1. iannotate workshop, April 2013 @ianmulvany head of technology - eLife Threads weaving together the scholarly literature, using an annotation based approach? image: flickr: vpickering Text
2. ✦ a storify for science? ✦ where the idea comes from? ✦ why is eLife interested? ✦ what we have done so far in this direction? ✦ what problems are there with the idea? ✦ what happens next?
3. ✦ how do you think it should be built? (what sucks about where we are heading?) ✦ what problems are we missing? ✦ would you be interested in helping?
4. Science sucks at getting better at doing science
6. image: flickr: designshard
7. Advertising Ads Brand navigation brand join account Search navigation Jobs issue navigation Article info Jobs Personal related, pubmed crossref tools alerts email rights content
8. Threads
9. ✦ 5 TeraBases ✦ 1715 × Human Genome ✦ 3k experiments ✦ 410 authors on the main paper ✦ 6 high profile papers ✦ ~35 companion papers ENCODE http://encodeproject.org/ENCODE/
11. ✦ Interactive figures ✦ Virtual machine with the analysis ✦ Threads Encode innovations
16. BLOB PROVENANCE
17. image: flickr: sfslim
18. genomeinformatician.blogspot.com/
19. ✦ building the thread gives overview of the topic ✦ could give credit to the composer ✦ readers benefit from well constructed threads ✦ easier to create than review articles ✦ explicitly shows the upside of OA CONTENT ✦ would be great not to have to do it in word
23. CC-BY
25. v1
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Cell 136: 777 \u2013 93.", "Crittenden SL Bernstein DS Bachorik JL Thompson BE Gallegos M Petcherski AG. 2002. A conser binding protein controls germline stem cells in Caenorhabditis elegans. Nature 417: 660 \u2013 3.", "Darnell RB. 2004. Paraneoplastic neurolog windows into neuronal function and tumor immunity. Arch Neurol 61: 30 \u2013 2.", "Darnell RB. 2006. Developing global insight into RNA regula Spring Harb Symp Quant Biol 71: 321 \u2013 7.", "Darnell RB Posner JB. 2006. Paraneoplastic syndromes affecting the nervous system. Semin Onco \u2013 98.", "Darnell RB. 1996. Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and Proc Natl Acad Sci USA 93: 4529 \u2013 36.", "Darnell RB. 2010. HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley In RNA 1: 266 \u2013 86.", "Darnell RB Posner JB. 2011. Paraneoplastic syndromes (contemporary neurology series). USA: Oxford University Press.", Sherman BT Hosack DA Yang J Gao W Lane HC. 2003. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4: P3.", Darnell RB. 2003. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Mo 23: 4687 \u2013 700.", "Dredge BK Stefani G Engelhard CC Darnell RB. 2005. Nova autoregulation reveals dual functions in neuronal splicing. EM \u2013 20.", "Dredge BK Jensen KB. 2011. NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsens decay of Rbfox2. PLoS One 6: e21585.", "Eom T Antar LN Singer RH Bassell GJ. 2003. Localization of a beta-actin messenger ribonucleoprotein co zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses. J Neurosci 23: 10433 \u2013 44.", "Fabian MR Son Filipowicz W. 2010. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 79: 351 \u2013 79.", "Gehman LT Stoilov P Magu A Lin CH Shiue L. 2011. The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet 43: 706 \u2013 11 10.1038/ng.841.", "Giorgi C Yeo GW Stone ME Katz DB Burge C Turrigiano G. 2007. The EJC factor eIF4AIII modulates synaptic strength and neuron expression. Cell 130: 179 \u2013 91.", "Goina E Skoko N Pagani F. 2008. Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a n exon 18 mutant. Mol Cell Biol 28: 3850 \u2013 60.", "Goodrich JS Clouse KN Schupbach T. 2004. Hrb27C, Sqd and Otu cooperatively regulate gurke localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis. Development 131: 1949 \u2013 58.", "Gu W Pan F Zhang H Bass
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Cell 136: 777 \u2013 93.", "Crittenden SL Bernstein DS Bachorik JL Thompson BE Gallegos M Petcherski AG. 2002. A conser binding protein controls germline stem cells in Caenorhabditis elegans. Nature 417: 660 \u2013 3.", "Darnell RB. 2004. Paraneoplastic neurolog windows into neuronal function and tumor immunity. Arch Neurol 61: 30 \u2013 2.", "Darnell RB. 2006. Developing global insight into RNA regula Spring Harb Symp Quant Biol 71: 321 \u2013 7.", "Darnell RB Posner JB. 2006. Paraneoplastic syndromes affecting the nervous system. Semin Onco \u2013 98.", "Darnell RB. 1996. Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and Proc Natl Acad Sci USA 93: 4529 \u2013 36.", "Darnell RB. 2010. HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley In RNA 1: 266 \u2013 86.", "Darnell RB Posner JB. 2011. Paraneoplastic syndromes (contemporary neurology series). USA: Oxford University Press.", Sherman BT Hosack DA Yang J Gao W Lane HC. 2003. DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol 4: P3.", Darnell RB. 2003. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. Mo 23: 4687 \u2013 700.", "Dredge BK Stefani G Engelhard CC Darnell RB. 2005. Nova autoregulation reveals dual functions in neuronal splicing. EM \u2013 20.", "Dredge BK Jensen KB. 2011. NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsens decay of Rbfox2. PLoS One 6: e21585.", "Eom T Antar LN Singer RH Bassell GJ. 2003. Localization of a beta-actin messenger ribonucleoprotein co zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses. J Neurosci 23: 10433 \u2013 44.", "Fabian MR Son Filipowicz W. 2010. Regulation of mRNA translation and stability by microRNAs. Annu Rev Biochem 79: 351 \u2013 79.", "Gehman LT Stoilov P Magu A Lin CH Shiue L. 2011. The splicing regulator Rbfox1 (A2BP1) controls neuronal excitation in the mammalian brain. Nat Genet 43: 706 \u2013 11 10.1038/ng.841.", "Giorgi C Yeo GW Stone ME Katz DB Burge C Turrigiano G. 2007. The EJC factor eIF4AIII modulates synaptic strength and neuron expression. Cell 130: 179 \u2013 91.", "Goina E Skoko N Pagani F. 2008. Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a n exon 18 mutant. Mol Cell Biol 28: 3850 \u2013 60.", "Goodrich JS Clouse KN Schupbach T. 2004. Hrb27C, Sqd and Otu cooperatively regulate gurke localization and mediate nurse cell chromosome dispersion in Drosophila oogenesis. Development 131: 1949 \u2013 58.", "Gu W Pan F Zhang H Bass
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A base-excision DNA-repair protein finds intrahelical lesion bases by fast slidi with DNA. Proc Natl Acad Sci USA 103: 5752 \u2013 7.", "Boutz PL Stoilov P Li Q Lin CH Chawla G Ostrow K. 2007. A post-transcriptional regulat polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes Dev 21: 1636 \u2013 52.", "Brennan CM Steit HuR and mRNA stability. Cell Mol Life Sci 58: 266 \u2013 77.", "Buckanovich RJ Darnell RB. 1997. The neuronal RNA binding protein Nova-1 recog RNA targets in vitro and in vivo. Mol Cell Biol 17: 3194 \u2013 201.", "Buckanovich RJ Posner JB Darnell RB. 1993. Nova, the paraneoplastic Ri homologous to an RNA-binding protein and is specifically expressed in the developing motor system. Neuron 11: 657 \u2013 72.", "Chao JA Patsko Levy M Almo SC Singer RH. 2010. ZBP1 recognition of beta-actin zipcode induces RNA looping. Genes Dev 24: 148 \u2013 58.", "Cooper TA Wan L Dr 2009. RNA and disease. Cell 136: 777 \u2013 93.", "Crittenden SL Bernstein DS Bachorik JL Thompson BE Gallegos M Petcherski AG. 2002. A conser binding protein controls germline stem cells in Caenorhabditis elegans. Nature 417: 660 \u2013 3.", "Darnell RB. 2004. Paraneoplastic neurolog windows into neuronal function and tumor immunity. Arch Neurol 61: 30 \u2013 2.", "Darnell RB. 2006. Developing global insight into RNA regula Spring Harb Symp Quant Biol 71: 321 \u2013 7.", "Darnell RB Posner JB. 2006. Paraneoplastic syndromes affecting the nervous system. Semin Onco \u2013 98.", "Darnell RB. 1996. Onconeural antigens and the paraneoplastic neurologic disorders: at the intersection of cancer, immunity, and Proc Natl Acad Sci USA 93: 4529 \u2013 36.", "Darnell RB. 2010. HITS-CLIP: panoramic views of protein-RNA regulation in living cells. Wiley In RNA 1: 266 \u2013 86.", "Darnell RB Posner JB. 2011. Paraneoplastic syndromes (contemporary neurology series). 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29. dev.elifesciences.org
30. XML Converter node.js JSON Article Viewer
31. Indicies nodes annotations
32. Indicies
33. nodes
34. annotations
35. http://elifesciences.github.io/articleviewer/#00005
37. Problems
39. Many still use paper Most use PDFs How do you get the of the researcher to care? How would you identify worthwhile threads How do you make it easy to use? What’s a sufficent volume of content?
41. XML is not uniform anyway :( No workflow tool will integrate, today DOI -> XML is not trivial Where are they stored?
42. Next steps ✦talk a bit more to the EBI ✦evaluate: ✦ how cheaply could we build it ✦ can we prove that it would be useful to people
43. ✦ how do you think it should be built? (what sucks about where we are heading?) ✦ what problems are we missing? ✦ would you be interested in helping?
44. We are hiring i.mulvany@elifesciences.org
45. flickr: OZinOH Journal of Open Research Software - JORS