Cyclobenzaprine Drug

Transcript

1. Cyclobenzaprine Skeletal Muscle Relaxant
2. Chemical Name 3-(5H-dibenzo[a,d]cyclohepten-5-ylidine)-N,N-dimethyl-1- propanamine hydrochloride Pharmacologic Class: Tricyclic Antidepressant Derivative
3. Trade Names Flexeril Amrix Fexmid
4. Then and Now… 1961 -> discovered to have antidepressant action ! 1977 -> FDA approved Flexeril ! 2007-> FDA approved Amrix ! 2010-> 1 billion tablets prescribed annually ! *Not a controlled substance
5. Pharmacokinetics Onset: 1 hour Peak: 4 hours Duration: 12-24 hours Half-life: 1-3 days Extended-release: 32 hours
6. Pharmacodynamics -> Works at the brainstem level of the CNS! ! -> Norepinephrine potentiation ! ! -> Central anticholinergic effects! ! -> Sedation
7. Pharmacotherapeutics Insomnia Tension Headaches Levator Ani Syndrome Acute muscle spasms Fibromyalgia Acute TMJ pain
8. Drug Interactions MAO inhibitors -> Hyperpyretic crisis; Seizures Guanathedine CNS depressants Naproxen -> Drowsiness Tramadol -> Seizures
9. Adverse Side Effects CNS: Dizziness, asthenia, seizures, dysarthia, syncope CV: Arrythmias, tachycardia, hypotension Skin: Rash, pruritus, acne GI: Nausea, dry mouth, abnormal taste EENT: Visual disturbances Serotonin Syndrome!
10. PTA Roles Communicate (LISTEN) Regular monitoring of vital signs Pain level check Prevent falls
11. 1.) Where does cyclobenzaprine act upon? a.) CNS b.) ANS c.) SSRI d.) SSTI 2.) What is the main adverse effect that PTAs must be aware of? ! a.) Dizziness b.) Pain c.) Dry mouth d.) BP of 128/70 3.) Cyclobenzaprine is effective against spasms due to cerebral or spinal cord disease.