HCP diffusion acquisition scheme C. Maffei , G. Girard , K. G. Schilling , N. Adluru , D. B. Aydogan , A. Hamamci , F. Yeh , M. Mancini , Y. Wu , A. Sarica , A. Teillac , S. H. Baete , D. Karimi , Y. Lin , F. Boada , N. Richard , B. Hiba , A. Quattrone , Y. Hong , D. Shen , P. Yap , T. Boshkovski , J. S. W. Campbell , N. Stikov , G. B. Pike , B. B. Bendlin , A. L. Alexander , V. Prabhakaran , A. Anderson , B. A. Landman , E. J.Z. Canales-Rodrígue , M. Barakovic , J. Rafael-Patino , T. Yu , G. Rensonnet , S. Schiavi , A. Daducci , M. Pizzolato , E. Fischi- Gomez , J. Thiran , G. Dai , G. Grisot , N. Lazovski , A. Puente , M. Rowe , I. Sanchez , V. Prchkovska , R. Jones , J. Lehman , S. Haber , A. Yendiki RESULTS FROM ROUND I
Introduction: Tractography limitations Previous challenges: • Limited angular or spatial resolution • Single acquisition scheme • Comparison using different brains IronTract challenge goals: • Understand which methods/processing strategies lead to optimal tractography accuracy for the two-shell HCP scheme • Investigate whether those methods could achieve even higher accuracy with a different acquisition scheme.
DSI + Multishell diffusion schemes DSI Grid Multishel l Evaluate wider range of methods Compare different sampling schemes Test methods for HCP sampling scheme True Positive Rate False Positive Rate Tractography results at different thresholds Investigate the Sensitivity-Specificity Tradeoff Compare different methods at the same FPR ROC Analysis Introduction: Why is this challenge unique?
for one injection site does not guarantee optimality for another Some methods showed consistently high performance in both datasets • Higher sensitivity for DSI than multishell HCP acquisition scheme When analysis methods are optimized, the HCP scheme may achieve similar accuracy Conclusions
for one injection site does not guarantee optimality for another Some methods showed consistently high performance in both datasets • Higher sensitivity for DSI than multishell HCP When analysis methods are optimized, the HCP scheme may achieve similar accuracy • Probabilistic tractography + CSD model + use of constraining masks = increased sensitivity Best method for HCP acquisition scheme Conclusions
for one injection site does not guarantee optimality for another Some methods showed consistently high performance in both datasets • Higher sensitivity for DSI than multishell HCP When analysis methods are optimized, the HCP scheme may achieve similar accuracy • Probabilistic tractography + CSD model + use of constraining masks = increased sensitivity Best method for HCP acquisition scheme • False negative mainly found far from injections site and at splitting regions Conclusions
the winner method? 2 winning strategies: post-processing filtering Use of constraining ROIs based on known anatomy Next Steps: IronTract ROUND II • We are asking participants to: Run their tractography method on harmonized preprocessed data Post-process their data using the two winning post-processing strategies
the winner method? 2 winning strategies: post-processing filtering Use of constraining ROIs based on known anatomy Next Steps: IronTract ROUND II • We are asking participants to: Run their tractography method on harmonized preprocessed data Post-process their data using the two winning strategies Monetary Prizes for winners! New Deadline: November 8th