Pasteur’s Quadrant is a classification proposed to describe research that is fundamental for the advancement of knowledge (basic research) but at the same time seeks for immediate solutions to real-world problems (use-inspired research). The name is a tribute to Louis Pasteur, whose scientific discoveries changed the way we view and prevent many diseases. In this talk, we first advocate that software engineering research should always target Pasteur’s Quadrant. Software engineering researchers should constantly look for hard, novel, and fundamental solutions (basic research) but that have an immediate contribution to software practitioners (use-inspired research). We then list some strategies that can help to deliver basic, but use-inspired scientific results. Finally, we share our experience on using these strategies in two recent projects from our research group, in the areas of software maintenance, evolution, and visualization.