Copyright © Elix, Inc. All rights reserved.4.*-&4ݴޠϞσϧ4NJMFT'PSNFSͷ։ൃͱͦͷԠ༻ྫגࣜձࣾ&MJYϦαʔνΤϯδχΞҪ্ وԝ
View Slide
ࢠߏͷઃܭͱਂߏੜث2
Copyright © Elix, Inc. All rights reserved. 3ҩༀΛ͡Ίͱ͢ΔػೳੑԽ߹ͷߏઃܭʹࢼߦࡨޡ͕ඞཁͰɺ࣌ؒͱίετ͕͔͔Δ➔ ߏઃܭͷखॱΛޮԽͰ͖ΔͱศརػೳੑԽ߹ͷ։ൃϓϩηεޭߏઃܭ߹ࢼݧࣦഊʜʜ
Copyright © Elix, Inc. All rights reserved. 4ߏੜث͋ΔछͷߏੜنଇΛ༻͍ͯίϯϐϡʔλ্ͰࢠߏΛൃੜͤ͞ΔϓϩάϥϜߏੜثΛ༻͍Δ͜ͱͰଟͷࢠߏΛੜͰ͖ΔଟͷࢠߏΛؚΉੜߏ܈͔Βɺॴͷੑ࣭Λ࣋ͭͱظ͞ΕΔ༗ͳԽ߹܈Λநग़͢Δ➔ ༗Խ߹܈ʹରͯ͠ࢼݧ͢Δ͜ͱͰɺߏઃܭͷखॱΛޮԽͰ͖Δͱظ͞ΕΔߏੜثߏੜث ੜߏ܈༗ߏ܈நग़ੜ
Copyright © Elix, Inc. All rights reserved. 5ਂߏੜث༩͑ΒΕͨσʔληοτ͔Βࣗಈநग़͞Εͨ ֬Ͱදݱ͞ΕΔߏੜنଇΛ༻͍ͨਂੜϞσϧࢠߏͷݱΕ͢͞ σʔλੜΛදݱ͢ΔྫһͱһͰɺһͷํ͕ݱΕ͍͢$ݪࢠͱ4ݪࢠͰɺ$ݪࢠͷํ͕ࢠʹଟؚ͘·Ε͍ͯΔࢠߏͷಛʹҰఆͷ͕͋Δ➔ ݱΕ͍͢ࢠߏʹରͯ͠ɺߴׂ͍͕֬ΓͯΒΕ͍ͯΔ➔ ܇࿅ࡁΈϞσϧ͔ΒͷαϯϓϦϯάͰɺ܇࿅αϯϓϧΒ͍͠ࢠߏΛੜͰ͖Δߏੜنଇੜੜߏ܈ਂߏੜثࢠߏσʔληοτنଇͷநग़
Copyright © Elix, Inc. All rights reserved.ఆྔతʹɺ࣍ͷΑ͏ͳࢦඪ͕Α͘ར༻͞Ε͍ͯΔ• ࢠߏͷ༗ޮੑ 7BMJEJUZੜ͞Εͨαϯϓϧͷ͏ͪɺਖ਼͘͠ࢠߏΛදݱͰ͖͍ͯΔͷͷׂ߹• ࢠߏͷ৽نੑ /PWFMUZੜߏ܈ͷ͏ͪɺ܇࿅σʔληοτʹؚ·Ε͍ͯͳ͍ͷͷׂ߹• ࢠߏͷଟ༷ੑ %JWFSTJUZҙͷੜߏϖΞʹର͢Δ5BOJNPUPڑ ࢠߏͷඇྨࣅͷฏۉͨͩ͠ɺ͜͏ͨ͠ࢦඪ͕ྑ͔ͬͨͱͯ͠ɺ࣮ࡍʹྑ͍ࢠߏ͕ಘΒΕΔ͔Ͳ͏͔ෆ໌࣮ࡍͷༀͰͷ༻Λఆͨ͠ઃఆͰɺਂߏੜثΛఆੑతʹධՁ͍ͨ͠➔ 4NJMFT'PSNFSͱ͍͏ਂߏੜثΛɺༀͷϦʔυδΣωϨʔγϣϯͷஈ֊ʹద༻ͯ͠ධՁਂߏੜثͷੑೳධՁͱͦͷ՝6
4NJMFT'PSNFS7
Copyright © Elix, Inc. All rights reserved. 8จࣈྻʹΑΔࢠߏͷදݱ4.*-&4จࣈྻࢠߏΛදݱ͢ΔͨΊͷจࣈྻ• Ұఆͷจ๏ʹैͬͯදه͞ΕΔ ҎԼจ๏ͷྫ◦ ೋॏ݁߹ l=zͰɺࡾॏ݁߹ l#zͰදه ಛʹॻ͔ͳ͍߹୯݁߹ͱղऍ◦ ओ͔Βͷࢬ͔ΕؙΧοί l()zͰදه◦ దͳลΛஅͯ͠ߟ͑ɺஅՕॴΛରԠ͢ΔࣈͰදه◦ ๕߳Λߏ͢ΔݪࢠখจࣈͰදه• ϞσϧͰੜ͍͢͠ࢠߏදݱ◦ 4.*-&4จࣈྻΛઌ಄͔ΒτʔΫϯ จࣈྻͷ࠷খߏ୯Ґͣͭੜ▪ τʔΫϯࣗવݴޠʹ͓͚Δ୯ޠʹ૬▪ ݩૉ͝ͱʹҰͭͷτʔΫϯΛͳ͢ͱߟ͑Δ͜ͱ͕ଟ͍◦ ੜ͞ΕΔจࣈྻ͕4.*-&4จ๏ʹԊΘͳ͍ ແޮͰ͋Δ͜ͱ͋ΓಘΔCC(=O)Nc1ccccc14.*-&4จࣈྻ
Copyright © Elix, Inc. All rights reserved. 94NJMFT'PSNFSೖྗग़ྗજࡏมΤϯίʔμσίʔμ5SBOTGPSNFS<>ͱݺΕΔχϡʔϥϧωοτϫʔΫΛ༻͍ͨਂߏੜث• छྨͷχϡʔϥϧωοτϫʔΫΛ༻͍ͯೖྗΛʮ༁ʯ͢Δ͜ͱͰࢠߏΛੜ͢Δ◦ Τϯίʔμ4.*-&4จࣈྻΛϕΫτϧ જࡏมʹม◦ σίʔμજࡏมΛͱʹͯ͠4.*-&4จࣈྻΛੜ• ೖྗ͞Εͨγʔυߏ ࢠߏɾϑϥάϝϯτߏ͔ΒજࡏมΛܭࢉ➔ ܭࢉ͞ΕͨજࡏมΛىͱͯ͠ɺજࡏมΛগͣͭͣ͠Β͠ͳ͕Βॴͷੑɾ׆ੑΛຬͨ͢Α͏ͳࢠߏΛग़ྗͰ͖ΔมΛ୳ࡧ*<>"7BTXBOJ FUBM/FVS*14
Copyright © Elix, Inc. All rights reserved.• ܇࿅αϯϓϧͷ4.*-&4จࣈྻΛมͨ͠จࣈྻ͔Βɺͱͷ4.*-&4จࣈྻΛ෮ݩͰ͖ΔΑ͏ʹ܇࿅• 4.*-&4จࣈྻͷมํ๏ ϥϯμϜʹબ͞ΕΔ◦ ෳϑϥάϝϯτͷׂ3&$"1ΞϧΰϦζϜͳͲΛར༻◦ 4.*-&4จࣈྻͷผදهͷม◦ μϛʔจࣈྻ l*z ͷஔ• ेͳͷ܇࿅αϯϓϧΛ༻͍Δͱɺೖྗ͞ΕͨγʔυߏΛదʹิͰ͖ΔΑ͏ʹͳΔ◦ ܇࿅ʹੑɾ׆ੑ͕ඞཁͳ͍➔ େྔʹ͋Δϥϕϧͳ͠αϯϓϧΛར༻Մೳ4NJMFT'PSNFSͷ܇࿅10CC1=CC=C(C=C1)C1=CC(=NN1C1=CC=C(C=C1)S(N)(=O)=O)C(F)(F)F܇࿅αϯϓϧͷ4.*-&4จࣈྻc1(C)ccc(-c2cc(C(F)(F)F)nn2-c2ccc(S(N)(=O)=O)cc2)cc1ผͷ4.*-&4จࣈྻදه[*]c1ccc(S(N)(=O)=O)cc1[*]c1cc(C(F)(F)F)nn1[*][*]c1ccc(C)cc1ϑϥάϝϯτׂ*μϛʔจࣈྻ4NJMFT'PSNFSͰ෮ݩϥϯμϜʹม
έʔεελσΟ11
Copyright © Elix, Inc. All rights reserved.త c࣮ࡍͷༀͰͷ༻Λఆͨ͠ઃఆͰɺਂߏੜثΛఆੑతʹධՁઃఆ cώοτԽ߹͔Βطଘༀͷυωϖδϧɺͦͷ෦ߏΛؚΉΞηνϧίϦϯΤεςϥʔθ"$I&્ࡎͷߏΛੜυωϖδϧ͕ൃݟ͞Εͨͷ͕ $I&.#-ʹه͞Ε͍ͯΔ➔ ҎલʹΒΕ͍ͯͨ"$I&્ࡎΛத৺ʹͯ͠ϞσϧΛ܇࿅ઃఆ12υωϖδϧͷൃݟ࣌ؒ࣠
Copyright © Elix, Inc. All rights reserved.ࣄલֶश༻σʔληοτ dສԽ߹• $I&.#-͔Βऔಘ ׆ੑσʔλར༻͠ͳ͍• 4NJMFT'PSNFSͷࣄલֶशͰ൚༻తͳϞσϧΛ࡞Δ• "$I&્ࡎ ສԽ߹ͱυωϖδϧࠎ֨Λͭߏ Խ߹আڈ"$I&્ࡎσʔληοτ• $I&.#-͔Β*$ͷ͍ͭͨ Խ߹Λऔಘ◦ ͏ͪɺҎલʹطͷԽ߹Λத৺ʹ܇࿅σʔληοτ "#$ Խ߹Λ࡞➔ 4NJMFT'PSNFSͷϑΝΠϯνϡʔχϯά׆ੑ༧ଌϞσϧͷߏஙʹར༻◦ υωϖδϧʹؔ࿈͢Δߏ͔ΒͳΔσʔληοτ%ݕূσʔληοτͱ͢Δσʔληοτͷ४උ13" #$FUDFUD FUD%FUDҎલʹൃݟ͞Εͨ"$I&્ࡎ "ͷࠎ֨Λ࣋ͭߏ Ҏ߱ʹൃݟ͞ΕͨͷؚΉώοτԽ߹ͱͦͷ༠ಋମ ϐϖϥδϯ ϐϖϦδϯ Πϯμϯࠎ֨Λ࣋ͭͷ
Copyright © Elix, Inc. All rights reserved.ਂߏੜث c&MJY %JTDPWFSZäʹ࣮͞Ε͍ͯΔ4NJMFT'PSNFSΛར༻• $I&.#-ͷԽ߹ dສԽ߹Ͱࣄલ܇࿅ͨ͋͠ͱɺ"$I&σʔληοτ "#$ Խ߹ͰϑΝΠϯνϡʔχϯά• ੜ࣌ෳͷධՁΛ༻͍ͨଟత࠷దԽΛ࣮ࢪ◦ ߹ՄೳੑείΞ 4"TDPSF◦ υϥοάϥΠΫωεࢦඪ 2&%◦ ·͍͠ཧԽֶతੑ࣭◦ ߏͷ৽نੑ ܇࿅σʔληοτ͔Βͷڑ◦ "$I&્׆ੑ༧ଌ༧ଌϞσϧ c&MJY %JTDPWFSZäʹ࣮͞Ε͍ͯΔάϥϑΈࠐΈωοτϫʔΫ ($/Λར༻• "$I&્׆ੑͷճؼϞσϧ"$I&σʔληοτ "#$ Խ߹Ͱ܇࿅➔ 4NJMFT'PSNFSͷ࠷దԽࢦඪɾੜߏͷϑΟϧλϦϯάʹར༻• ݂ӷؔ ###ಁաੑͷྨϞσϧผ్༻ҙͨ͠σʔληοτ Խ߹Ͱ܇࿅➔ ੜߏͷϑΟϧλϦϯάʹར༻Ϟσϧͷ४උ14
Copyright © Elix, Inc. All rights reserved.ੜ༻ͷγʔυߏͷछྨ γʔυߏͳ͠ γʔυߏʹμϛʔจࣈྻ * Λೖྗ ୯Ұͷγʔυߏ υωϖδϧൃݟͷݩʹͳͬͨώοτԽ߹<> ෳͷγʔυߏ ͷߏʹྨࣅͨ͠Խ߹ߏੜͱϑΟϧλϦϯάɾϥϯΩϯάγʔυߏΛͱʹສݸͷߏΛੜ º ճ➔ ֤ηοτʹରͯ͠ɺϑΟϧλϦϯά ߏͷϥϯΩϯά• ϑΟϧλϦϯά-JQJOTLJͷ30 ෦ߏʹΑΔϑΟϧλϦϯά ߏͷ৽نੑ ###ಁա֬• ϥϯΩϯά"$I&׆ੑ༧ଌͱυϥοάϥΠΫωε 2&%ΛͱʹϥϯΫ͚ߏੜํ๏15<>)4VHJNPUP FUBM+QO+1IBSNBDPM r
Copyright © Elix, Inc. All rights reserved.࣮ݧ݁Ռ16υωϖδϧࠎ֨ υωϖδϧࠎ֨ͷྨࣅߏγʔυߏͳ͠ γʔυߏ ݸ γʔυߏ ෳݸ Λ࣋ͭͷ*$O.3BOL*$O.3BOL*$O.3BOL*$O.3BOLυωϖδϧݸͷγʔυߏΛ༻͍ͯੜ͞Εͨ"$I&્ࡎ ෳݸͷγʔυߏΛ༻͍ͯੜ͞Εͨ"$I&્ࡎ*$O.3BOL*$O.3BOL*$O.3BOL*$O.3BOLυωϖδϧ➔ ώοτԽ߹Λγʔυߏʹར༻͢Δ͜ͱͰɺυωϖδϧΛؚΉ"$I&્ࡎͷ࠶ൃݟʹޭ
Copyright © Elix, Inc. All rights reserved. 17• 4NJMFT'PSNFS5SBOTGPSNFSΛ༻͍ͨਂߏੜث◦ ೖྗ͞Εͨࢠߏɾϑϥάϝϯτߏ͔ΒજࡏมΛܭࢉ➔ ܭࢉ͞ΕͨજࡏมΛىͱͯ͠ɺજࡏมΛগͣͭͣ͠Β͠ͳ͕Βॴͷੑɾ׆ੑΛຬͨ͢Α͏ͳࢠߏΛग़ྗͰ͖ΔมΛ୳ࡧ• 4NJMFT'PSNFSΛར༻ͯ͠υωϖδϧͷݩͱͳͬͨώοτԽ߹͔Βυωϖδϧؔ࿈Խ߹Λੜ◦ ࣮ࡍͷༀͰͷ༻Λఆͨ͠ઃఆͰɺ4NJMFT'PSNFSΛఆੑతʹධՁ◦ ώοτԽ߹Λγʔυߏʹར༻͢Δ͜ͱͰɺυωϖδϧΛؚΉ"$I&્ࡎͷ࠶ൃݟʹޭ·ͱΊ
Elix, Inc.https://elix-inc.com/Copyright © Elix, Inc. All rights reserved.