Problem 1a: Common problem with large scale screenings Confirmation via manual, low-throughput methods (e.g. RNA-Seq analysis followed by northern blots to confirm candidates) http://www.flickr.com/photos/library_of_congress/2179123671/
Problem 1b: Scaling up experiments 10 - 100 repetitions possible 1000 and more repetitions not possible http://www.flickr.com/photos/library_of_congress/2179123671/
Problem 1c: Craft vs. thinking Why does somebody who studied several years need to spend most of his/her time pipetting one liquid into another? http://www.flickr.com/photos/library_of_congress/2179123671/
Advantages of having a formal language for actions Transparency Reproducibility Scalability https://secure.flickr.com/photos/jurvetson/2018232 – CC-BY by flickr user jurvetson
Claim We need more automation / formalization – especially in the life sciences. https://secure.flickr.com/photos/jurvetson/2018232 – CC-BY by flickr user jurvetson
Motos ”Work on the business/system not in the business/system.” ”Be productive not busy.” ”Laziness is a virtue.” https://secure.flickr.com/photos/jurvetson/2018232 – CC-BY by flickr user jurvetson
Challenges Price (as long as not coming a commondity) Lack of flexibility Formalization is hard Vendor lock-in ⇒ open standards required https://secure.flickr.com/photos/jurvetson/2018232 – CC-BY by flickr user jurvetson
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