Simulation Model for 3D-printed Drug Development

Transcript

1. Haque Ishfaq PhD Researcher Montreal Institute for Learning Algorithms (MILA);

   School of Computer Science McGill University, Canada @haqueishfaq Samara Sharmeen Resident Surgeon VIVANTES Netzwerk für Gesundheit GmbH RWTH Aachen University, Germany @ssharmeen Hassan Sami Adnan Medical Researcher Faculty of Health, Medicine and Life Sciences, Maastricht University World Health Organization (WHO) @hsami Hassan Saad Ifti DPhil Researcher Department of Engineering Science University of Oxford, United Kingdom @saadifti Atia Amin Researcher Department of Biology University of South Dakota, United States @atiaamin1 Simulation Model for 3D-printed Drug Development

2. 0 2000 4000 6000 8000 1999 2001 2003 2005 2007

   2009 2011 2013 2015 2017 2019 Digital Health Deep Learning Artificial Intelligence Number of publications on PubMed, on three different topics Emerging trend in medicine

3. Print your tablet at home… A dream?

4. Patients over 60 need 15 to 20 tablets a day

   on average.

5. Combining multiple APIs in Side view Cross section

6. Drug release profiles

7. What can be a possible solution?

8. A fluid dynamic approach:
 drug delivery though porous scaffolds

9. Flow through porous scaffolds p (internal) p (external) < p

   (internal)

10. Gauss-Seidel iterative algorithm NumPy implementation

11. Pressure distribution across table wall

12. Limitations in printing resolution Capel, A., Rimington, R., Lewis, M.,

    & Christie, S. (2018). 3D printing for chemical, pharmaceutical and biological applications. Nature Reviews Chemistry, 2(12), 422-436. doi: 10.1038/ s41570-018-0058-y pore size in microns (10-6 m)

13. PySTEMPlus @PySTEM Haque Ishfaq PhD Researcher Montreal Institute for Learning

    Algorithms (MILA); School of Computer Science, McGill University, Canada @haqueishfaq Samara Sharmeen Resident Surgeon VIVANTES Netzwerk für Gesundheit GmbH; RWTH Aachen University, Germany @ssharmeen Hassan Sami Adnan Medical Researcher Faculty of Health, Medicine and Life Sciences, Maastricht University; World Health Organization (WHO) @hsami Hassan Saad Ifti DPhil Researcher Department of Engineering Science; University of Oxford, United Kingdom @saadifti Atia Amin Researcher Department of Biology University of South Dakota, United States @atiaamin1 Outreach platform for underprivileged children PyHEALTH Bridging IT and Healthcare Follow us on Twitter for latest updates on our research. Our next event Hosting the first ever Python coding camp for children in Mym, Bangladesh! PySTEMPlus @PySTEM Haque Ishfaq PhD Researcher Montreal Institute for Learning Algorithms (MILA); School of Computer Science, McGill University, Canada @haqueishfaq Samara Sharmeen Resident Surgeon VIVANTES Netzwerk für Gesundheit GmbH; RWTH Aachen University, Germany @ssharmeen Hassan Sami Adnan Medical Researcher Faculty of Health, Medicine and Life Sciences, Maastricht University; World Health Organization (WHO) @hsami Hassan Saad Ifti DPhil Researcher Department of Engineering Science; University of Oxford, United Kingdom @saadifti Atia Amin Researcher Department of Biology University of South Dakota, United States @atiaamin1 Outreach platform for underprivileged children PyHEALTH Bridging IT and Healthcare Follow us on Twitter for latest updates on our research. Our next event Hosting the first ever Python coding camp for children in Mym, Bangladesh! MPlus @PySTEM n Aachen Hassan Sami Adnan Medical Researcher Faculty of Health, Medicine and Life Sciences, Maastricht University; World Health Organization (WHO) @hsami Hassan Saad Ifti DPhil Researcher Department of Engineering Science; University of Oxford, United Kingdom @saadifti Atia Amin Researcher Department of Biology University of South Dakota, United States @atiaamin1 underprivileged children TH are Follow us on Twitter for latest updates on our research. Our next event Hosting the first ever Python coding camp for children in Mym, Bangladesh!