candidate drugs using tensor-decomposition-based unsupervised feature extraction in integrated analysis of gene expression between diseases and DrugMatrix datasets”, Scientific Reports,7:13733 (2017)
3 i =x j 1 j 2 i x j 3 i =∑G(l 1 ,l 2 ,l 3 ,l 4 )u l 1 j 1 u l 2 j 2 u l 3 j 3 u l 4 i x j 1 j 2 i u l 1 j 1 u l 2 j 2 u l 3 j 3 u l 4 i j 1 j 2 j 3 i 化合物 投与後時刻 患者対 健常者 遺伝子 Gene X 標的タンパク
with primary biliary cirrhosis”, Drug Des Devel Ther. 2015 ;9:5407-19. CONCLUSION: Combination therapy improved liver biochemistry and the prognosis of PBC, but did not improve clinical symptoms or incidence of death. Attention should be paid to adverse events when using bezafibrate.