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テンソル分解による糖尿病の組織特異的遺伝子発現の統合解析を用いた関連疾患の予測

Y-h. Taguchi
February 28, 2025

 テンソル分解による糖尿病の組織特異的遺伝子発現の統合解析を用いた関連疾患の予測

Y-h. Taguchi

February 28, 2025
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  1. ςϯιϧ෼ղʹΑΔ౶೘පͷ ૊৫ಛҟతҨ఻ࢠൃݱͷ ౷߹ղੳΛ༻͍ͨؔ࿈࣬ױͷ༧ଌ (Taguchi et al., Genes 2022, 13(6), 1097)

    Y.-H. Taguchi, Turki Turki தԝେֶ ཧ޻ֶ෦ ෺ཧֶՊ Ωϯάα΢υେֶ ίϯϐϡʔλՊֶՊ 2025 ೥݄̏̒೔ Taguchi & Turki (MDPI) SIGBIO81 2025 ೥݄̏̒೔ 1 / 18
  2. εϥΠυ֓ཁ 1 ݚڀഎܠͱ໨త 2 ςϯιϧ෼ղͷجૅ 3 HOSVD ղੳख๏ͱσʔλ 4 ݁Ռͷ֓ཁ

    5 ߟ࡯ͱԠ༻Մೳੑ 6 ݁࿦ͱࠓޙͷల๬ 7 ࢀߟจݙ Taguchi & Turki (MDPI) SIGBIO81 2025 ೥݄̏̒೔ 2 / 18
  3. ݚڀഎܠʢ2/2ʣ ैདྷ͸୯Ұ૊৫Ͱͷࠩ෼ղੳʢt ݕఆ, SAM, limma ౳ʣ͕ओྲྀ͕ͩɺશ਎ੑ࣬ױͷશମ૾Λे ෼ʹ͸ଊ͖͑Εͳ͍Մೳੑ͕͋Δɻ ຊݚڀͰ͸ɺςϯιϧ෼ղ (TD) Λ༻͍ͯϚϧν

    ૊৫Ҩ఻ࢠൃݱσʔλΛಉ࣌ʹղੳ͠ɺ౶೘පʹ ෇ਵ͢Δ࣬ױʢ༨පʣΛਪఆ͢Δɻ ໨తɿ୯Ұ૊৫ղੳͱൺֱ͠ͳ͕Βɺ౷߹ղੳͷ ϝϦοτΛݕূ͢Δͱͱ΋ʹɺ৽ͨͳ࣬ױؔ࿈৘ ใΛൃ۷͢Δɻ Taguchi & Turki (MDPI) SIGBIO81 2025 ೥݄̏̒೔ 4 / 18
  4. ςϯιϧ෼ղʢTDʣͱ͸ ςϯιϧɿଟ࣍ݩ഑ྻɻҨ఻ࢠ ʷ ૊৫ ʷ ࣌ؒ ʷ ॲஔ ʜͳͲɺ3 ࣍ݩΛ௒͑Δσʔλߏ଄ɻ

    HOSVD (Higher-Order SVD)ɿߴ࣍ݩͷಛҟ஋ ෼ղʹΑΓɺίΞςϯιϧͱ֤Ϟʔυͷಛҟ஋ϕ Ϋτϧ΁෼ղ͢Δɻ ڭࢣͳ͠ख๏Ͱ͋Γɺෳ਺৚݅ɾ૊৫Λಉ࣌ʹ ѻͬͯ΋৘ใΛଛͳΘͣɺજࡏతͳมಈཁҼΛந ग़Մೳɻ ϙΠϯτ ୯Ұ૊৫͝ͱͷղੳͰ͸ݟ͑ͮΒ͍ʮԣஅతͳಛ௃ʯ Λଊ͑ΒΕΔͷ͕ڧΈɻ Taguchi & Turki (MDPI) SIGBIO81 2025 ೥݄̏̒೔ 5 / 18
  5. HOSVDղੳϑϩʔʢ֓೦ਤʣ ʢ࿦จຊฤ Figure 1 ͳͲͷղੳύΠϓϥΠϯΛ૝ఆʣ 1) Ϛϧν૊৫σʔλΛߴ࣍ݩςϯιϧͱͯ͠ߏங 2) HOSVD Ͱ෼ղ

    ˠ ಛҟ஋ϕΫτϧ͔ΒมಈྔେͷҨ఻ࢠ Λબ୒ 3) બ୒Ҩ఻ࢠΛΤϯϦονϝϯτղੳ͠ɺؔ࿈࣬ױɾܦ࿏ Λ୳ࡧ Taguchi & Turki (MDPI) SIGBIO81 2025 ೥݄̏̒೔ 6 / 18
  6. σʔλͱղੳͷྲྀΕ Ϟσϧಈ෺ɿϥοτʢ౶೘පϞσϧ vs. ରরʣ3 ૊৫ʢ؊ଁɺے೑ɺࢷ๱ʣʷ ෳ਺ि ʷ 2 ܥ౷ ˠ

    6 ࣍ݩԽ ςϯιϧߏஙɿҨ఻ࢠ (∼ 31k) ʷ ि ʷ ݸମ ʷ ॲஔ (౶೘ප/ରর) ʷ ܥ౷ ʷ ૊৫ HOSVD Λద༻͠ɺओཁมಈ੒෼Λநग़ มಈྔ͕େ͖͍Ҩ఻ࢠʢ໿ 2542 ϓϩʔϒʣΛબ୒ ˠ Enrichr ౳Ͱػೳ෋ूղੳ Taguchi & Turki (MDPI) SIGBIO81 2025 ೥݄̏̒೔ 7 / 18
  7. ݁Ռʢ1/4ʣ ɿղੳख๏ൺֱ ղੳख๏ ༗ҙҨ఻ࢠ਺ ے೑༝དྷ උߟ ఏҊ (TD) ∼2542 ଟ਺

    ౷߹ղੳ SAM (૊৫ผ) ਺ඦఔ౓ গ਺ ૊৫୯ಠ limma (૊৫ผ) ਺ेఔ౓ 2 ΄Ͳ ૊৫୯ಠ ComBat + ղੳ ਺ඦఔ౓ গ਺ όονิਖ਼ TD ͸ैདྷख๏ΑΓ޿ൣғͳҨ఻ࢠΛݕग़͠ɺے೑ͰͷมಈΛଊ͑΍ ͍͢ɻ ౷߹ղੳͳΒͰ͸ͷ༏Ґੑ͕ࣔࠦ͞ΕΔɻ Taguchi & Turki (MDPI) SIGBIO81 2025 ೥݄̏̒೔ 9 / 18
  8. ݁Ռʢ3/4ʣ ɿؔ࿈࣬ױͷΤϯϦονϝ ϯτ Taguchi et al., Genes 2022, 13(6), 1097,

    Figure 2 (ྫ) Taguchi & Turki (MDPI) SIGBIO81 2025 ೥݄̏̒೔ 11 / 18
  9. ࢀߟจݙ I Taguchi, Y.-H.; Turki, T. Genes 2022, 13(6), 1097.

    https://www.mdpi.com/2073-4425/13/6/1097 Taguchi, Y.-H.; Turki, T. (Supplementary Materials), https://www.mdpi.com/article/10.3390/genes13061097/s1 Taguchi & Turki (MDPI) SIGBIO81 2025 ೥݄̏̒೔ 17 / 18