cultural or technological systems? – Similar processes of varia1on, inheritance and selec1on and driF occur in all systems – Understanding processes in one may shed light on the others – Goal is to build models of innova1on that span different systems
genes (2055 aa) (Peterson et al. 2004) • 118 taxa represen1ng all major metazoan clades • 24 calibra1on points: vertebrate + invertebrate • Relaxed molecular clock analyses: CIR clock model in Phylobayes • All es1mates tested under various sensi1vity analyses; all appear robust
Specify the spa1al domain of a part of the developing embryo, oFen a regional pafern • The kernels are dedicated to development and are not re-‐used elsewhere • Interference with the func1on of any gene will destroy kernel func1on • This forces subsequent evolu1onary change either upstream or downstream of the kernel
developmental regulatory interac1ons • Changes in some parts of regulatory networks are easier than in others • Some types of changes, par1cularly the establishment of kernels, appears to have been easier early in metazoan evolu1on; these kernels are now highly refractory to modifica1on
dis1nct (contrast with varia1on on established themes) • Innova)on occurs when inven1ons become economically or ecologically significant Invention & Innovation Joseph Schumpeter (1883-1950
environmental senng (physical, gene1c, ecologic) • Actualized by gene1c and developmental innova1ons leading to a new clade • Refined by further developmental and ecological changes • Realized as innova1ons by ecological expansion and evolu1onary success