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Stress-induced mutagenesis & complex adaptation

Yoav Ram
March 12, 2015

Stress-induced mutagenesis & complex adaptation

A short presentation on the effect of stress-induced mutagenesis on complex adaptation. Presented at the Two2Many Systems Biology conference in Weizmann Institute, March 2015.

Yoav Ram

March 12, 2015
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  1. Stress-induced mutagenesis
    & complex adaptation
    Yoav Ram
    Hadany Lab
    Dept. of Molecular Biology and Ecology of Plants
    Life Sciences Faculty
    1
    March 12 2015
    Two2Many
    Weizmann Inst.

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  2. D. Melanogaster
    Stress-induced
    mutation
    2
    Green algea
    Bacillus subtilis
    Nematodes
    M. tuberculosis
    E. coli
    L. monocytogenes
    Breast cancer cell

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  3. Causes and consequences of Stress-
    induced mutation
    • Evolution of stress-induced mutation:
    • SIM can evolve due to 2nd order selection
    • In constant and changing environments
    Ram & Hadany, Evolution 2012
    • Consequences of stress-induced mutation:
    • Effect on complex adaptation
    Ram & Hadany, Proceedings B 2014
    3

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  4. 4
    Low peak
    Valley
    High peak
    ←Fitness→
    ←Genotype→
    Sewall Wright
    Adaptive peak shifts

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  5. Methods
    • Model
    – Follow allele frequencies over many generations
    – Probability of appearance of adapted mutant
    – Probability of fixation of adapted mutant
    • Simulations
    – Stochastic realizations of analytic model
    – Statistical analysis of many replicates
    5
    ′ =

    + 1 − 1 −

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  6. Adaptation rate
    6
    Analytic model
    Simulations
    CM: constitutive mutation
    SIM: stress-induced mutation

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  7. SIM breaks the trade-off between
    adaptability and adaptedness
    7

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  8. Acknowledgments
    Amalia Biron-
    Zigle
    Foundation
    8
    Lilach Hadany
    Uri Obolski
    Ariel Guiejman
    Eyal Zinger
    [email protected]
    @yoavram
    www.yoavram.com
    CONTACT
    Manna Center
    for Plants
    Biosciences

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