Stress-induced mutagenesis & complex adaptation

A short presentation on the effect of stress-induced mutagenesis on complex adaptation. Presented at the Two2Many Systems Biology conference in Weizmann Institute, March 2015.

Transcript

1. Stress-induced mutagenesis & complex adaptation Yoav Ram Hadany Lab Dept. of Molecular Biology and Ecology of Plants Life Sciences Faculty 1 March 12 2015 Two2Many Weizmann Inst.
2. D. Melanogaster Stress-induced mutation 2 Green algea Bacillus subtilis Nematodes M. tuberculosis E. coli L. monocytogenes Breast cancer cell
3. Causes and consequences of Stress- induced mutation • Evolution of stress-induced mutation: • SIM can evolve due to 2nd order selection • In constant and changing environments Ram & Hadany, Evolution 2012 • Consequences of stress-induced mutation: • Effect on complex adaptation Ram & Hadany, Proceedings B 2014 3
4. 4 Low peak Valley High peak ←Fitness→ ←Genotype→ Sewall Wright Adaptive peak shifts
5. Methods • Model – Follow allele frequencies over many generations – Probability of appearance of adapted mutant – Probability of fixation of adapted mutant • Simulations – Stochastic realizations of analytic model – Statistical analysis of many replicates 5 ′ = + 1 − 1 −
6. Adaptation rate 6 Analytic model Simulations CM: constitutive mutation SIM: stress-induced mutation
7. SIM breaks the trade-off between adaptability and adaptedness 7
8. Acknowledgments Amalia Biron- Zigle Foundation 8 Lilach Hadany Uri Obolski Ariel Guiejman Eyal Zinger yoavram@gmail.com @yoavram www.yoavram.com CONTACT Manna Center for Plants Biosciences