Stress-induced mutagenesis & complex adaptation

A short presentation on the effect of stress-induced mutagenesis on complex adaptation. Presented at the Two2Many Systems Biology conference in Weizmann Institute, March 2015.

Transcript

1. Stress-induced mutagenesis
   & complex adaptation
   Yoav Ram
   Hadany Lab
   Dept. of Molecular Biology and Ecology of Plants
   Life Sciences Faculty
   1
   March 12 2015
   Two2Many
   Weizmann Inst.
   

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2. D. Melanogaster
   Stress-induced
   mutation
   2
   Green algea
   Bacillus subtilis
   Nematodes
   M. tuberculosis
   E. coli
   L. monocytogenes
   Breast cancer cell
   

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3. Causes and consequences of Stress-
   induced mutation
   • Evolution of stress-induced mutation:
   • SIM can evolve due to 2nd order selection
   • In constant and changing environments
   Ram & Hadany, Evolution 2012
   • Consequences of stress-induced mutation:
   • Effect on complex adaptation
   Ram & Hadany, Proceedings B 2014
   3
   

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4. 4
   Low peak
   Valley
   High peak
   ←Fitness→
   ←Genotype→
   Sewall Wright
   Adaptive peak shifts
   

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5. Methods
   • Model
   – Follow allele frequencies over many generations
   – Probability of appearance of adapted mutant
   – Probability of fixation of adapted mutant
   • Simulations
   – Stochastic realizations of analytic model
   – Statistical analysis of many replicates
   5
   ′ =
   
   + 1 − 1 −
   

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6. Adaptation rate
   6
   Analytic model
   Simulations
   CM: constitutive mutation
   SIM: stress-induced mutation
   

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7. SIM breaks the trade-off between
   adaptability and adaptedness
   7
   

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8. Acknowledgments
   Amalia Biron-
   Zigle
   Foundation
   8
   Lilach Hadany
   Uri Obolski
   Ariel Guiejman
   Eyal Zinger
   yoavram@gmail.com
   @yoavram
   www.yoavram.com
   CONTACT
   Manna Center
   for Plants
   Biosciences
   

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