Physical Activity Analysis of Rheumatoid Arthritis Patients

These slides contain a summary of my Master's research project, which focuses on analysing the physical activities of rheumatoid arthritis patients.

Transcript

1. Physical Activity Analysis of Rheumatoid Arthritis Patients Elvyna Tunggawan Supervised by Dr Charlotte M. Jones-Todd and Dr Rebecca Meiring
2. 2 Image source: [5] What is rheumatoid arthritis (RA)? • Autoimmune disorder, symmetrical nature [2, 3] • Limited physical activity, leads to frustration & higher risk of having heart disease [1, 4] Research Problem • Any changes in the activities after RA patients got drugs treatment? • Does spending more time in particular activity affect their health? [1] Ahlstrand, I., Björk, M., Thyberg, I., Börsbo, B., and Falkmer, T. (2012). Pain and daily activities in rheumatoid arthritis. Disability and Rehabilitation, 34(15):1245–1253. [2] Bullock, J., Rizvi, S. A., Saleh, A. M., Ahmed, S. S., Do, D. P., Ansari, R. A., and Ahmed, J. (2018). Rheumatoid Arthritis: A Brief Overview of the Treatment. Medical Principles and Practice, 27(6):501–507. [3] Dewing, K. A., Setter, S. M., and Slusher, B. A. (2012). Osteoarthritis and Rheumatoid Arthritis 2012: Pathophysiology, Diagnosis, and Treatment. Clinical Advisor. [4] Fenton, S. A., van Zanten, J. J. V., Duda, J. L., Metsios, G. S., and Kitas, G. D. (2018). Sedentary behaviour in rheumatoid arthritis: definition, measurement and implications for health. Rheumatology, 57(2):213–226. [5] Posalski, J., & Weisman, M. (2009). Articular and Periarticular Manifestations of Established Rheumatoid Arthritis. In Rheumatoid Arthritis, chapter 5A, pages 49-61, Mosby, Philadelphia, USA.
3. Literature Review • Positive association between sedentary behaviour and cardiovascular disease risk in RA patients [1, 2] 3 + + = 24 hours Image source: HealingExercise.org [1] Fenton, S. A., van Zanten, J. J. V., Kitas, G. D., Duda, J. L., Rouse, P. C., Yu, C.-a., and Metsios, G. S. (2017). Sedentary behaviour is associated with increased long-term cardiovascular risk in patients with rheumatoid arthritis independently of moderate-to-vigorous physical activity. BMC Musculoskeletal Disorders, 18(1):131. [2] Hammam, N., Ezeugwu, V. E., Rumsey, D. G., Manns, P. J., and Pritchard-Wiart, L. (2019). Physical activity, sedentary behavior, and long-term cardiovascular risk in individuals with rheumatoid arthritis. The Physician and Sportsmedicine, 47(4):463–470.
4. Datasets 4 Activity Data Image sources: actigraphcorp.com & inventrn.org Health Data EDA: Step Count Cyclic pattern: more steps during the day
5. Step Count Modelling 5 *awake time: between 6 AM (inclusive) and 9 PM (exclusive)
6. Sedentary Behaviour Modelling 6 *awake time: between 6 AM (inclusive) and 9 PM (exclusive)
7. Activity Compositions during the Day* No statistically significant difference of the activities across the periods • ActiGraph: p = 0.285 • activPAL: p = 0.405 7 *between 6 AM (inclusive) and 9 PM (exclusive)
8. What is the association between each activity and their health? 8 +1 hour of stepping a day … • Baseline: up to +11.39 points (avg: 5.85) • Follow-up: up to +9.42 points (avg: 4.57)
9. Conclusion 9 Future Work • No statistically significant change in the activities. After the treatment was given: ◦ On average, fewer step counts -- but they took more steps during the day! ◦ Lower odds of being sedentary • Spending more time in stepping by an hour a day improves the overall health quality by 5.85 and 4.57 points in the baseline and follow-up period, respectively • Improvement of ActiGraph activity type classification [1, 3] • Assess the one-to-one relationship between each activity type [2] [1] Ahmadi, M., O’Neil, M., Fragala-Pinkham, M., Lennon, N., and Trost, S. (2018). Machine learning algorithms for activity recognition in ambulant children and adolescents with cerebral palsy. Journal of Neuroengineering and Rehabilitation, 15(105). [2] Dumuid, D., Željko Pedišić, Stanford, T. E., Martín-Fernández, J.-A., Hron, K., Maher, C. A., Lewis, L. K., and Olds, T. (2019). The compositional isotemporal substitution model: A method for estimating changes in a health outcome for reallocation of time between sleep, physical activity and sedentary behaviour. Statistical Methods in Medical Research, 28(3):846–857. [3] Sasaki, J. E., Hickey, A., Staudenmayer, J., John, D., Kent, J. A., and Freedson, P. S. (2016). Performance of Activity Classification Algorithms in Free-Living Older Adults. Medicine and Science in Sports and Exercise, 48(5):941–950.
10. 10 Questions? @vexenta linkedin.com/in/elvyna speakerdeck.com/elvyna