Injuries to the musculoskeletal system occur in a variety of ways. They are most commonly caused by forces generated by mechanical energy, but they can also result from exposure to excessive heat, chemicals, or electricity. Injuries to muscles and related tissues such as tendons and ligaments are technically soft tissue injuries, but the close relationship between these tissues and the skeleton make it more useful to consider musculoskeletal injuries separately.
Although musculoskeletal injuries are typically painful, they are rarely life-threatening. However, when not recognized and treated promptly, they can result in permanent disability or death. Musculoskeletal injuries are especially dangerous when a bone breaks and the fractured ends cause damage to other internal structures such as vital organs or blood vessels. They are also dangerous when a displaced part of the bone puts pressure on blood vessels, resulting in vascular compromise and tissue death. In these cases, the soft tissue injury is the life-threatening condition, but the cause is the fracture.