(in thousands, except share data) Convertible Preferred Stock Common Stock Additional Paid−in Capital Deferred Stock− Based Compen− sation Accumulated Other Compre− hensive Income Compre− hensive Loss Accum− ulated Deficit Total Stock− holders' (Deficit) Equity Shares Amount Shares Amount Balances as of January 1, 2000 4,444,545 $ 4 2,074,160 $ 2 $ 16,092 $ (6,841) $ — $ (41,285) $ (32,028) Exercise of options and issuance of restricted stock — — 81,003 — 422 — — — 422 Repurchase of restricted stock — — (26,653) — (141) — — — (141) Issuance of common stock in exchange for services rendered — — 7,258 — 306 — — — 306 Warrants issued in connection with operating lease — — — — 216 — — — 216 Warrants issued in connection with services rendered — — — — 285 — — — 285 Warrants issued in connection with debt financing — — — — 105 — — — 105 Subscribed Series F non−voting preferred stock — — — — 6,128 — — — 6,128 Deferred stock−based compensation, net — — — — 11,228 (11,228) — — — Stock−based compensation expense — — — — — 8,803 — — 8,803 Net loss — — — — — — — $ (57,363) (57,363) (57,363) Appreciation (depreciation) in value of available−for−sale securities — — — — — — — — — — Comprehensive loss — — — — — — — $ (57,363) — — Balances as of December 31, 2000 4,444,545 4 2,135,768 2 34,641 (9,266) — (98,648) (73,267) Exercise of options — — 30,046 — 125 — — — 125 Repurchase of restricted stock — — (5,625) — (12) — — — (12) Issuance of common stock in exchange for services rendered — — 1,666 — 10 — — — 10 Warrants issued in connection with subordinated notes payable — — — — 10,884 — — — 10,884 Warrants issued in connection with capital lease obligation — — — — 172 — — — 172 Warrants issued in exchange for services rendered — — — — 18 — — — 18 Issuance of Series F non−voting preferred stock 1,712,954 2 — — 4,279 — — — 4,281 Subscribed Series F non−voting preferred stock — — — — 217 — — — 217 Deferred stock−based compensation, net — — — — 2,145 (2,145) — — — Stock−based compensation expense — — — — — 5,686 — — 5,686 Net loss — — — — — — — $ (38,618) (38,618) (38,618) Appreciation (depreciation) in value of available−for−sale securities — — — — — — — — — — Comprehensive loss — — — — — — — $ (38,618) — — Balances as of December 31, 2001 6,157,499 6 2,161,855 2 52,479 (5,725) — (137,266) (90,504) Exercise of options — — 438,838 — 1,287 — — — 1,287 Issuance of common stock under Employee Stock Purchase Plan — — 47,746 — 363 — — — 363 Repurchase of restricted stock — — (1,729) — (6) — — — (6) Issuance of Series F non−voting preferred stock 3,492,737 4 — — 1,314 — — — 1,318 Issuance of common stock, net of costs — — 6,328,084 6 86,208 — — — 86,214 Conversion of preferred stock into common stock (9,650,236) (10) 3,216,740 3 7 — — — — Conversion of redeemable convertible preferred stock into common stock — — 9,659,700 10 101,820 — — — 101,830 Issuance of common stock upon exercise of warrants — — 594,561 1 195 — — — 196 Deferred stock−based compensation, net — — — — 15,505 (15,505) — — — Stock−based compensation expense — — — — — 9,831 — — 9,831 Net loss — — — — — — — $ (21,947) (21,947) (21,947) Appreciation (depreciation) in value of available−for−sale securities — — — — — — 774 774 — 774 Comprehensive loss — — — — — — — $ (21,173) — — Balances as of December 31, 2002 — $ — 22,445,795 $ 22 $ 259,172 $ (11,399) $ 774 $ (159,213) $ 89,356 See accompanying notes to financial statements. F−5