A talk given at Toulouse Data Science meetup in April 2016. Slightly adjusted version (I went into more detail due to time) of my talk from PyData Amsterdam. I spoke about the current PyData ecosystem, what you use things for and what you don't. What tools are expected soon and what is mature right now/ will be more mature in the future. Tools mentioned include Dask, Pandas, NumPy, Numba, Cython, Spark and Bcolz. I included code examples too.