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Drug repositioning based on bounded nuclear nor...

土屋貴穂
August 19, 2019

Drug repositioning based on bounded nuclear norm regularization

ISMB/ECCB 2019読み会
Drug repositioning based on bounded nuclear norm regularization
http://dx.doi.org/10.1093/bioinformatics/bty013

土屋貴穂

August 19, 2019
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  1. ࠓճ෮ݩ͍ͨ͠ߦྻ͸%SVH%JTFBTFؔ܎ͷྡ઀ߦྻ  طଘༀͷ৽ͨͳదԠ঱ྫΛެ։σʔλ͔Βਪఆ͍ͨ͠ <-VPFUBM #JPJOGPSNBUJDT > Data setはGottlieb et al,

    2011のもの # Gold standardなデータセット l 593 drugs l 313 diseases l 1933 validated Drug-Disease associations ただし… Drug-Disease associationsは 全組み合わせのうち 約99%が未知のスパースな行列データ ノイズも多分に含むという 対処すべき問題があった
  2. ϊΠζΛߟྀͨ͠ਖ਼ଇԽͰैདྷख๏ʹ΄΅׬উͨ͠  l ઌ΄Ͳͷߦྻ෮ݩ໰୊ࣗମ͸ຊ࿦จใࠂάϧʔϓʹΑΓطʹੑೳྑ͘ ղ͘ΞϧΰϦζϜ͕ใࠂ͞Ε͍ͯΔ <-VPFUBM #JPJOGPSNBUJDT > l ຊ࿦จͰ͸ϊΠζΛߟྀͨ͠ਖ਼ଇԽʹΑΓ͞ΒʹੑೳΛ޲্ͤͨ͞

    ˠ εύʔεͳσʔλʹ༗༻ͳख๏͕ධՁ͞Εͯ࠾୒͞ΕͨͷͰ͸ (JUIVCͰίʔυ͸ެ։͞Ε͍ͯͯɺ."5-"#Ͱ࣮૷͞Ε͍ͯΔ ఏҊख๏ #ounded Nuclear Norm Regularization (BNNR) ैདྷख๏
  3. ఏҊख๏Ͱ͸ϊΠζ·Ͱ෮ݩ͠ͳ͍Α͏ਖ਼ଇԽͨ͠  ఏҊख๏ #ounded Nuclear Norm Regularization (BNNR) ैདྷख๏ ஶऀΒͷΞϓϩʔν

    ϊΠζ ϊΠζͷਪఆ͸ݱ࣮తͰ͸ͳ͍ͱͯ͠ɺ̎ͭͷ੍໿ΛೖΕͯ໰୊Λ؇࿨ͨ͠ Ћͷ஋͸ࠓճ༻͍ͨσʔληοτʹ ରͯ͠GPMEDSPTTWBMJEBUJPOΛߦ͍ ࠷΋ੑೳ͕ߴ͘ͳΔΑ͏ʹܾఆͨ͠