Monepantel and Drug Resistance

The following presentation is an introduction to monepantel, a common dewormer for sheep and cattle that is rapidly loosing effectiveness due to drug resistance. More advanced topics are covered here, including its mechanisms of action and highlights from the first study of its effect on new potential drug targets.

Publication cited:
Baur, R., Beech, R., Sigel, E., & Rufener, L. (2015). Monepantel irreversibly binds to and opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 receptors. Molecular pharmacology, 87(1), 96–102. https://doi.org/10.1124/mol.114.095653

https://pubmed.ncbi.nlm.nih.gov/25352042/

Monepantel and Drug Resistance © 2021 by U. Nomi vs. Parasites, licensed under CC BY-NC-SA 4.0

Transcript

1. January 2023 Monepantel & Drug Resistance Photo: Andrea Lightfoot on https://unsplash.com January 2023
8. % Resistant Worms Sheep Performance →
49. References Baur, R., Beech, R. N., Sigel, E., & Rufener, L. (2014). Monepantel Irreversibly Binds to and Opens Haemonchus contortus MPTL-1 and Caenorhabditis elegans ACR-20 Receptors. Molecular Pharmacology, 87(1), 96–102. https://doi.org/10.1124/mol.114.095653 James, C., Hudson, A. L., & Davey, M. W. (2009). Drug resistance mechanisms in helminths: is it survival of the fittest? Trends in Parasitology, 25(7), 328–335. https://doi.org/10.1016/j.pt.2009.04.004 Lecová, L., Stuchlíková, L. R., Prchal, L., & Skálová, L. (2014). Monepantel: the most studied new anthelmintic drug of recent years. Parasitology, 141(13), 1686–1698. https://doi.org/10.1017/s0031182014001401