Goals • Reproduce • Similar behavior in other genes/samples? • Do simulated reads predict observed data? Get a measure by gene • Even more than by chance?
Measures by gene: using single bp exon • Correlation (R^2) • RMSD: scaling by max first • ARIMA: forecast models – Auto ARIMA on obs – Fit again using simulated data as predictor – P-value for predictor and estimated coef • Chance: – Neg. binomial size 1 and 6 – Compare replicates of simulated data