allele and gene expression with high accuracy in any mouse derived from one or more of the CC/DO founder strains. • For 500-‐1k genes with concordant e/pQTL, we can predict protein abundance in any mouse derived from the CC/DO founder strains. – We can predict the gene$c variants underlying these e/pQTL. • Use the mouse to ﬁnd blood/urine/stool biomarkers of $ssue transcript/protein abundance. Variants > Endophenotypes > Disorder • Expression Gene$cs-‐guided Model Development. • By applying genome edi$ng (CRISPR/Cas) to next genera$on mapping popula$ons, we can ﬁx known risk alleles to amplify and iden$fy novel low-‐eﬀect variants.