The presentation is based on a paper by the presenter (published in the Business Process Management Journal). It reports on the design of a field tested framework for improving knowledge-intensive business processes. It addresses a gap in the area of knowledge-based process improvement identified via a literature review. It also addresses weaknesses and shortcomings related to the knowledge aspects of business processes of established process improvement methodologies such as TQM and Six Sigma. The proposed framework is based on Karl Popper’s evolutionary epistemology of Objective Knowledge and integrates concepts and techniques typically applied in business process management and knowledge management. Through the conduct of three case studies, the improvement framework is applied and evaluated in real organisational settings. The lessons learned from these case studies and practical applications of the framework are discussed.