Engineering meta-space of science: An Exploration of Scientific Management Models

at DeSci Berlin

Transcript

1. Engineering meta-space of science An Exploration of Scientific Management Models Hiro Taiyo Hamada, Ph.D Araya Inc./DeSci Tokyo @HiroTHamadaJP
2. Purpose of this talk Share a view of the metascience movement as the valley of death in Research and Development (R&D) Provide an understanding of new players and insights into further ways of engineering R&D.
3. Decline of disruptive science and technology [Park et al., Nature, 2023]
4. New Players in Science Non-profit organizations DeSci Profit Organizations
5. Exploration of Meta-space of Science [Nielsen&Qiu et al., 2022] meta-space of R&D present R&D system metascience entrepreneur Players who expand the meta-space of science.
6. Exploration of Meta-space of Science [Nielsen&Qiu et al., 2022] meta-space of R&D present R&D system DeSci Metascience Entrepreneur Players who expand the space of science. FRO PARPA Lab Automation Crowd Labs
7. Evidence of More Private Funnding on Research [Shekhtman et al., 2022] https://arxiv.org/abs/2206.10661
8. Philanthrocapitalism [Bishop&Green, 2008]: Philanthropic movement to fix the failure of markets e.g. The Giving Pledge Impact Funding: Funding for Social Impact and Issues Effective Altruism [MacAskill, 2014]: Help others with the best ways Possibly reflection of global social issues Drivers of Private Funding Founded by Bill&Melinda Gates, Warren Buffett.
9. Center for Open Science Founded by Prof. Brian Nosek Promotion of Reproducible Science Open Science Framework (OSF) Over $28M by Arnold Ventures, LLC Evidence-based policymaking with transparent science Transparent Science by Private Funding https://www.arnoldventures.org/work [Open Science Collaboration, 2015]
10. Issues including Social Process in Science Multiple attempts and private funding began from 2010s or earlier. These attempts can be viewed as an exploration of the meta-space of science. Interim Summary
11. SBIR: Small Business Innovation Research since 1983 Governments support small businesses with high-tech. Examples: iRobot etc. Introduced in multiple regions UK: SBRI 2001 & UK SMART Grant 2011 EU: SME Instrument 2014- Japan: Japanese SBIR 1999- A historical example of exploration in R&D https://www.sbir.gov/about DoD SBIR-STTR National Economic Impact Study 1995-2018
12. Pre-seed Seed Funding Gap Early Growth Market Failures in Technology Transfer (TT) Funding gap between research and development High risk for VC No capital from academia and companies Valley of Death (1998) Market Failure in Technology Transfer Phase 1 Phase 2 Phase 3 SBIR Valley of Death Roland Tibets Program Officer NSF
13. FRO Grant DAO PARPA etc. New Ideas Overcoming Valley of Death in R&D
14. Proposed by Adam Marblestone Coordinated small group (fulltime10-30 members) Mission-driven technology transfer Domain-specific Time limit: 5-7 years e.g. Rejuvenome, Convergent Research Focused Research Organization (FRO) https://www.convergentresearch.org/ Pre-seed Seed Funding Gap Early Growth FRO
15. Pre-seed Seed Funding Gap Early Growth Companies TLO / DAO Academia Grant DAO in DeSci Grant DAO in DeSci Community-based funding and management Similar to the Technology Licensing Organization (TLO) e.g. YEDA Technology Transfer through IP-NFT e.g. VitaDAO, AthenaDAO etc. Catalysis of R&D by Alok Tayi, Ph.D. (Vibe Bio)
16. Creating portfolio funding different programs Milestone-based de-risking multiple “forms” over time 1: 1-5 people, program creation 2: 5-20 people, architecting institute 3: 20-100 people, an Institute for Creative Technology Private ARPA Pre-seed Seed Funding Gap Early Growth Form 1 Form 2 Form 3 PARPA https://benjaminreinhardt.com/parpa#parpa_will_go_through_three_phases_of_organizational_growth
17. Pre-seed Seed Funding Gap Early Growth Valley of Death Phase3 Phase2 Phase1 SBIR FRO FRO mega pharma Non- profit/profit model Companies DAO Academia grantDAO Profit organization Non-profit organization Form 3 Form 2 Form 1 PARPA
18. Pre-seed Seed Funding Gap Early Growth Hypothetical DAOs DAO grantDAO research DAO Focused Research DAO research DAO Research DAO is in charge of seed research with members with multiple backgrounds. focused- research DAO (FRD) FR DAO is a mission-driven DAO directly funded by crowds or companies.
19. Focus on R&D as technology transfer Clear target in the R&D process Hypothetical program/organization ideation Domain risk is not well specified. Unclear intermediary within each step Unclear time and functional constrains Pros Cons Pros/Cons on “Valley of Death” Framework
20. Historical examples preventing market failures from the 1980s or earlier. SBIR/STTR ARPA Non-profit organizations drive present attempts. grant DAOs/FRO/PARPA/ The meta-science movement can be understood as overcoming the valley of death in R&D by engineering the unexplored space of science. Summary Slides are available
21. References [Cheng, 2023] https://youtu.be/_mLdx48B7zE [Shekhtman et al., 2022] https://arxiv.org/abs/2206.10661 [Nielsen & Kanjun Qiu, 2022] https://scienceplusplus.org/metascience/index.html [Park et al., 2023] https://doi.org/10.1038/s41586-022-05543-x PARPA:https://benjaminreinhardt.com/parpa#parpa_will_go_through_three_ph ases_of_organizational_growth Effective Altruism https://web.archive.org/web/20200220215628/https://forum.effectivealtruis m.org/posts/9a7xMXoSiQs3EYPA2/the-history-of-the-term-effective-altruism
22. References Convergent research https://www.convergentresearch.org/ SBIR: https://www.sbir.gov/about Arnold Ventures: https://www.arnoldventures.org/work
23. Pre-seed Seed Funding Gap Early Growth Companies TLO / DAO Academia Grant DAO in DeSci Grant DAO in DeSci Community-based funding & and management Similar to the Technology Licensing Organization (TLO) e.g. YEDA Technology Transfer through IP-NFT Catalysis of R&D companies Researcher Supporters IP DAO Return IP Funding Fund ing Return