In 2017-2018, to simplify the deployment, allow easier automation and have better scaling options, HubSpot MySQL databases, previously run on RDS and EC2 instances, were migrated to Vitess and Kubernetes. In this talk, we share our experience of 4+ years running Percona Server with Vitess on Kubernetes in AWS: things that worked well, others that we had to adapt, and some open problems we are still facing. We will cover sharding, the automation tooling, and our journey to multi-region. The audience will be presented with a real-world, large MySQL/Vitess/Kubernetes deployment: you will learn from what we built, and hopefully avoid some of our mistakes. Come to this talk to see how HubSpot operate 800+ MySQL MySQL replication clusters / keyspaces with Vitess and Kubernetes.