MtaB MtaC MtbB MtbC MtbA CoM-S-S-CoB CoM-SH+HS-CoB Fdox Fdred 2H2 4H+ HdrB HdrC MvhG MvhA HdrA MvhD 1-2,5,8 1-2,5 FrhG FrhA F420 H2 F420 H2 2H+ 1-4 1-4 MttB MttA MttC HS-CoM CH3 S-CoM Biosynthesis F420 CH4 H2 MtrA MtrH CH3 -S-CoM H2 H2 H2 +HS-CoM +HS-CoM +HS-CoM 3 1-3,7 1-4,6 1-4 1-4 2-4,7 ATP ADP ATPase 1-4,6-8 1-2,6 FrhB 1-2,6 1-5,7 1-2,5,7 1-2,5-7 4 NiFe H+ H2 FdOX Fdred 2e- 8 ? ? 2e- ? De Anda et al, Nature Microbiology, Submitted H2 -dependent methylotrophic pathway Electron donor Electron acceptors Energy conserved by a proton gradient generated by electron bifurcation PPi 2Pi H+ HppA 1-7 H+ H+ H+