All about High Shear Mixer Granulator

High Shear Mixer Granulator is the equipment used during a wet mixing, homogenizing granulating, and drying of powder in a variety of industries like pharmaceuticals, chemicals, cosmetics, food and beverage, and general mixing industries. It offers a controlled and effective channelized process to achieve product homogeneity, fluidity, stability with the mechanism of a lower heat transfer and a clean and hygienic air medium using proven manufacturing expertise.
An impeller is employed in mixing the dry powder and spreading the granulating fluid in high shear granulator normally rotates at different ranging speeds. The chopper forms part of the high shear granulator and is used to break down the wet lump to produce granules. These rapid mixer granulators are categorized into two types which are the vertical axis and horizontal axis and can be operated either continuously or in batches. They are used in pharmaceutical industries due to their capability to manage difficult feed formulations comprising fine cohesive powders and high viscosity binder fluids. A vertical high shear granulator is one in which the impeller shaft rotates in a vertical plane and the impellers are blade-like. It could be a top-driven or bottom-driven unit. In a horizontal high shear granulator, the impeller shaft rotates in the horizontal plane.

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Transcript

1. All About High Shear Mixer Granulator
2. Need of High Shear Mixer Granulator ✓ Used to mix the ingredients for granule preparation before compression. ✓ Has controlled & effective channelized process. ✓ Helps to achieve product homogeneity & fluidity. ✓ Provides stability with mechanism of lower heat transfer. ✓ Ensures clean & hygienic air medium using proven manufacturing expertise.
3. Important Parts of Rapid Mixer Granulator ✓ A cylindrical or a conical cylindrical mixing drum ✓ An impeller with a trio blade system ✓ A primary chopper and a supplementary chopper ✓ Motor and a discharge pot
4. Advantages of High Shear Mixer Granulator ❑ Granulation machine offers a lot of advantages such as: ✓ Need small quantity of binder solution for granulation process. ✓ Helps in prediction of granulation endpoint. ✓ Reproducible less friable granules with uniform particle size distribution. ✓ Minimizes any exposure of drug dust to workers. ✓ Greater densification and production of less friable granules.
5. Factors Affecting Granulation Process of High Shear Granulator ❑ Physical properties of the material to be granulated ❑ Type & quantity of the excipients used ❑ Type & amount of binder solution used in the process ❑ Various process variables include : ✓ Load of granulator bowl ✓ Impeller speed ✓ Granular design ✓ Wet massing tire
6. Industries Using Rapid Mixer Granulators ✓ Pharmaceuticals ✓ Chemicals ✓ Cosmetics ✓ Food & beverage ✓ General mixing industries
7. Why Shree Bhagwati Pharma? ✓ Shree Bhagwati Pharma is involved in offering pharmaceutical project consultancies for turn key projects that are in line with international standards such as the WHO – GMP, USFDA, MHRA, TGA and cGMP rules andregulations. ✓ These leads to flexibility and cost effectiveness, while at the same time meeting the required regulatory requirements.
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