This case study investigates the design and implementation of an introductory database course that addresses the diverse needs of deaf and hard-of-hearing (DHH) students at the National University Corporation Tsukuba University of Technology (NTUT) in Japan. The course incorporates self-regulated learning and constructive interaction approaches, drawing upon various learning science theories and practices to create an inclusive learning environment. The course features lecture videos with sign language, subtitles, transcripts, and learning sessions combining individual study, peer collaboration, and interactive follow-up with instructors. Cross-reviews and practical group exercises promote knowledge construction and deeper understanding. Insights from the course implementation in 2023 highlight the potential of innovative instructional designs to enhance learning outcomes for DHH students in higher education and offer practical strategies for designing accessible and effective courses for diverse student populations.