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Reporting your results for publication according to guidelines

Graeme Hickey
October 03, 2016

Reporting your results for publication according to guidelines

Presented at the 30th Annual EACTS Meeting, Barcelona, Spain (1-5 October 2016)

Graeme Hickey

October 03, 2016
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  1. How to perform more advanced statistics: basics and pitfalls
    Graeme L. Hickey
    Department of Biostatistics, University of Liverpool
    * No conflicts of interest

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  3. URL: http://www.oxfordjournals.org/our_journals/ejcts/for_authors/manuscript_instructions.html

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  4. Development and validation of risk prediction models
    Clinical randomized trials
    Systematic reviews and meta-analyses
    Comprehensive database of guidelines
    www.equator-network.org

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  5. URL: http://www.consort-statement.org
    Supplemental file for manuscript submission Manuscript figure

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  7. + corrigendum: Eur J Cardio-Thoracic Surg 2016;49:1024.

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  8. • Above all

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  9. Examples* of common ‘issues’
    (which are covered in the EJCTS and ICVTS
    guidelines)
    * A somewhat haphazard collection

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  11. * Austin, P. C. (2007). Propensity-score matching in the cardiovascular surgery literature from 2004 to 2006: a systematic review and suggestions for
    improvement. The Journal of Thoracic and Cardiovascular Surgery, 134(5), 1128–35.

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  12. à

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  13. Table 1. Patient and operative characteristics data by CPB technique with statistical
    comparison.
    518
    Overall On-pump Off-pump Δ (%) P
    Total number n=3402 n=1173 n=2229
    Logistic EuroSCORE (%) 2.4 ± 2.5 2.4 ± 2.8 2.3 ± 2.3 1.8 0.965
    Age (years) 61.7 ±10.6 61.1 ± 10.3 61.9 ± 10.7 -8.1 0.026
    BMI (kg/m2) 28.5 ± 4.6 28.7 ± 4.7 28.4 ± 4.5 6.1 0.090
    N % N % N %
    Female 880 25.9% 325 27.7% 555 24.9% 6.4 0.083
    Preoperative AF 69 2.0% 28 2.4% 41 1.8% 3.8 0.343
    Urgent 733 21.5% 271 23.1% 462 20.7% 5.7 0.119
    NYHA III/IV 645 19.0% 225 19.2% 420 18.8% 0.9 0.846
    History of neurological
    dysfunction 53 1.6% 25 2.1% 28 1.3% 6.8
    0.070
    Diabetes (insulin or diet
    controlled) 600 17.6% 207 17.6% 393 17.6% 0.0
    >0.999
    * Continuous data reported as mean ± standard deviation
    Percentages correctly
    rounded
    Appropriate and
    consistent precision
    Columns clearly labeled
    Notation defined
    Units included
    Number of subjects
    sum correctly

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  14. 0 200 400 600 800 1000
    0.0 0.2 0.4 0.6 0.8 1.0
    Time
    CumSum
    An unacceptably presented Kaplan−Meier graph
    P0.0
    0.2
    0.4
    0.6
    0.8
    1.0
    0 6 12 18 24 30
    Time from diagnosis (months)
    Survival probability
    Male
    Female
    138 86 35 17 7 2
    90 70 30 15 6 1
    No. at risk
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    An acceptably presented Kaplan−Meier graph
    Log−rank test P = 0.001

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  15. [1] https://www.biostat.wisc.edu/~kbroman/topten_worstgraphs/
    [2] https://garstats.wordpress.com/2016/05/27/the-percentile-bootstrap/
    • Statistical figures are for summarizing complex data
    • Readers will be drawn to them, so they need to be clearly presented
    • Label all axes – and report what is being shown

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  16. Interpreting randomized trial data: Tuesday 4th October 14:15 - 15:45

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  18. Editorial Board
    Friedhelm Beyersdorf (Editor-in-
    Chief)
    Joel Dunning (Associate Editor)
    Judy Gaillard (Managing Editor)
    Franziska Lueder (Editorial
    Manager)
    Assistant Editors
    (Statistical Consultants)
    Burkhardt Seifert
    Gottfried Sodeck
    Matthew J. Carr
    Hans Ulrich Burger
    Graeme L. Hickey
    + all other editorial members

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