Un-blinded RCT Hospital based outpatient clinics in U.K. December 1999 → August 2004 → January 2006 Outcomes Time to treatment failure Time to 12 month remission Arm Patients Standard Drug Typical Seizure Type Randomised Drugs A 1721 CBZ Focal Onset CBZ, GBP, LTG, TPM, OXC* B 716 VPS Generalised Onset VPS, LTG, TPM Marson, A.G., et al., The SANAD study of effectiveness of carbamazepine, gabapentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet, 2007. 369(9566): p. 1000-15. Marson, A.G., et al., The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial. Lancet, 2007. 369(9566): p. 1016-26.