Most Vital Problem of Cell Biology?

A fun presentation given at the European Bioinformatics Institute, Cambridge, UK on the Institute day.

Transcript

1. Most vital problem of cell biology?
2. Data explosion 0 25 50 75 100 125 150 1982 1992 2002 2011 GenBank sequences (millions) 0 250 500 750 1000 1250 1500 1996 2001 2006 2011 NAR databases number http://www.ncbi.nlm.nih.gov/genbank/genbankstats.html http://www.oxfordjournals.org/nar/database/a/
3. Systems Biology approach Components Pathway data Concentrations Pathway model Reaction rates
4. Super Cell
5. How it works Stimuli Response ArrayExpress Ensembl GenBank Virtual Cell Biomodels UniProt Reactome ... EGA ...
6. Benefits Drug Food ... Result Industry Research Knowledge Medicine
7. Plan EBI clusters 20 people 5 years Organism €10 million Literature & Databases analysis Collaboration with other EBI groups Preliminary assumptions & validation
8. Global trend